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1.发明授权Process of making synthetic absorbable autoclaveable monofilament fibers and brachytherapy seed spacers 有权制造合成可吸收的高压灭菌单丝纤维和近距离放射治疗种子间隔物的方法公开(公告)号：US06419866B1
公开(公告)日：2002-07-16
申请号：US09468463
申请日：1999-12-21
申请人： John J. Karl , Nicholas Popadiuk , Dennis D. Jamiolkowski , Kenneth Michael Keilman , Sa{haeck over (s)}a Andjelić
发明人： John J. Karl , Nicholas Popadiuk , Dennis D. Jamiolkowski , Kenneth Michael Keilman , Sa{haeck over (s)}a Andjelić
IPC分类号： A61M3600
CPC分类号： D01F6/62 , A61N2005/1023 , D01F6/84
摘要： The present invention is directed to absorbable, autoclaveable, monofilament fibers prepared from absorbable glycolide-rich polymers, in which the fibers are oriented in the total draw ratio range 4.1 to 5.6×, and are annealed at a temperature between about 165° C. and about 185° C.; to brachytherapy seed spacers manufactured from the absorbable, autoclaveable, glycolide-rich polymers, monofilament fibers; and to methods of manufacturing such fibers and brachytherapy seed spacers.
摘要翻译： 本发明涉及由可吸收的富含乙交酯的聚合物制备的可吸收的，可高压灭菌的单丝纤维，其中纤维以总拉伸比范围为4.1至5.6x取向，并在约165℃和 约185℃。 由可吸收的，可高活性的富含乙交酯的聚合物，单丝纤维制成的近距离放射治疗种子间隔物; 以及制造这种纤维和近距离放射治疗种子间隔物的方法。
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2.发明申请Segmented, Semicrystalline Poly(Lactide-co-epsilon-Caprolactone) Absorbable Copolymers 审中-公开分段，半结晶聚（丙交酯 - 共 - 己内酯）可吸收共聚物公开(公告)号：US20130236499A1
公开(公告)日：2013-09-12
申请号：US13417810
申请日：2012-03-12
CPC分类号： C08G63/08 , A61L17/12 , A61L27/18 , A61L27/58 , C08G63/912
摘要： Novel semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. The novel polymer compositions are useful for long term absorbable meshes, surgical sutures, especially monofilament sutures, and other medical devices.
摘要翻译： 公开了具有长期吸收特性的丙交酯和ε-己内酯的新型半结晶分段共聚物。 新型聚合物组合物可用于长期可吸收网眼，手术缝合线，特别是单丝缝合线和其它医疗装置。
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3.发明申请公开(公告)号：US20120323273A1
公开(公告)日：2012-12-20
申请号：US13330741
申请日：2011-12-20
IPC分类号： A61L17/10
CPC分类号： A61L17/10 , A61B17/0401 , A61B17/06066 , A61B17/06166 , A61B2017/00004 , A61B2017/00893 , A61B2017/0414 , A61B2017/0458 , A61B2017/06171 , A61L17/005 , A61L17/04 , A61L17/06 , A61L17/105 , A61L17/145 , A61L2300/402 , A61L2300/406 , A61L2300/41 , D04C1/12 , D10B2509/04
摘要： A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
摘要翻译： 一种具有最小不吸收质量的新型高抗拉强度半吸收复合缝合线。 缝线具有由生物可吸收聚合物制成的芯。 芯由编织护套覆盖。 编织护套由可吸收纱线和生物可吸收纱线制成。 生物可吸收纱线由生物可吸收聚合物的至少一根丝制成。 非吸收性纱线由至少一根超高分子量聚乙烯丝制成。
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4.发明授权Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof 有权生物可吸收多孔增强组织植入物及其植入物的制备方法公开(公告)号：US07368124B2
公开(公告)日：2008-05-06
申请号：US10383369
申请日：2003-03-07
申请人： Iksoo Chun , Dennis D. Jamiolkowski , Kelly R. Brown , Julia Hwang , Francois Binette , Mora Carolynne Melican
发明人： Iksoo Chun , Dennis D. Jamiolkowski , Kelly R. Brown , Julia Hwang , Francois Binette , Mora Carolynne Melican
IPC分类号： A61F13/00
CPC分类号： A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant is disclosed. The tissue implant may be bioabsorbable, and is made from a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a common solvent.
摘要翻译： 公开了生物相容性组织植入物。 组织植入物可以是生物可吸收的，并且由生物相容的聚合物泡沫制成。 组织植入物还包括生物相容性加强构件。 聚合物泡沫和增强构件可溶于常用溶剂。
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公开(公告)号：US07169187B2
公开(公告)日：2007-01-30
申请号：US10602338
申请日：2003-06-24
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： The present invention is directed to stents that are formed into a helical structure having a plurality of coils, a longitudinal axis, an internal longitudinal passage, a distal section and a proximal section having different diameters; where the structure is made from a fiber having a cross-section and including an inner core having an exterior surface made from a biodegradable polymer having a first degradation rate and an outer section made from a blend of a first biodegradable polymer component and a second biodegradable polymer component covering the exterior surface of the inner core and having a second degradation rate; where the second degradation rate is lower than the first degradation rate.
摘要翻译： 本发明涉及形成具有多个线圈，纵向轴线，内部纵向通道，远端部分和具有不同直径的近端部分的螺旋结构的支架; 其中结构由具有横截面的纤维制成，并且包括具有由具有第一降解速率的生物可降解聚合物制成的外表面的内芯和由第一可生物降解的聚合物组分和第二可生物降解的共混物制成的外部部分 聚合物组分覆盖内芯的外表面并具有第二降解速率; 其中第二降解速率低于第一降解速率。
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公开(公告)号：US07163562B2
公开(公告)日：2007-01-16
申请号：US10059637
申请日：2002-01-29
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a pre-determined period of time through normal flow of body fluids passing through the lumen.
摘要翻译： 用于植入人体内腔的可生物降解支架。 一个实施方案中的支架由具有内芯和外层的生物可降解纤维制成。 外层是两种聚合物组分的混合物。 内核具有第一降解率，外层具有第二降解率。 第二降解速率比第一降解速率慢。 纤维在体内软化，使得支架在通过通过管腔的体液的正常流动在预定时间段之后容易地作为软化碎片或细丝从内腔通过。
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公开(公告)号：US5681351A
公开(公告)日：1997-10-28
申请号：US327248
申请日：1994-10-21
CPC分类号： A61B17/0487 , A61B17/0401 , A61B2017/00004 , A61B2017/0445 , A61B2017/0454 , Y10T24/3969 , Y10T24/3996
摘要： The present invention provides a suture clip for attachment to at least one suture comprising a suture clip body having a central longitudinal axis, a proximal end, a distal end, an inner surface, an outer surface and a proximal surface, wherein the inner surface forms a passage that is substantially parallel to the longitudinal axis and is connected to the outer surface by a longitudinal slot which extends from the distal end to the proximal end of the suture clip body and the proximal surface has a major dimension at least five times larger than the diameter of said suture and a collar disposed about said suture clip body engaging the outer surface of the suture clip body to deflect the inner surface to frictionally engage the suture. Also described herein are methods of using this suture clip in surgical procedures.
摘要翻译： 本发明提供一种用于连接至至少一条缝合线的缝线夹，其包括具有中心纵向轴线，近端，远端，内表面，外表面和近端表面的缝合夹主体，其中内表面形成 通道，其基本上平行于纵向轴线并且通过纵向槽连接到外表面，所述纵向狭槽从缝合夹主体的远端延伸到近端，并且近端表面的主要尺寸至少大于 所述缝合线的直径和围绕所述缝合夹主体设置的衣领与缝合夹主体的外表面接合以使内表面偏转以摩擦地接合缝合线。 本文还描述了在外科手术中使用该缝合夹的方法。
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公开(公告)号：US5597579A
公开(公告)日：1997-01-28
申请号：US611532
申请日：1996-03-05
IPC分类号： A61K47/34 , A61K9/20 , A61K9/22 , A61L15/22 , A61L15/26 , A61L15/60 , A61L17/00 , A61L17/10 , A61L27/18 , A61L27/52 , A61L29/04 , A61L29/06 , A61L29/14 , A61L31/00 , A61L31/04 , A61L31/06 , C08G63/664 , C08G63/672 , C08G69/40 , C08G69/44 , C08L67/00 , C08L67/02 , C08L77/12 , C09D167/00 , C09D177/12 , A61F2/00
CPC分类号： C08G69/44 , A61K9/204 , A61L15/225 , A61L15/26 , A61L15/60 , A61L17/105 , A61L27/18 , A61L27/52 , A61L29/049 , A61L29/06 , A61L29/145 , A61L31/041 , A61L31/06 , C08G63/664 , C08G63/672 , C08G69/40 , C08L67/00 , C08L67/025 , C08L77/12 , C09D167/00 , Y10T428/1352 , Y10T428/1355 , Y10T428/1362 , Y10T428/24 , Y10T428/249921 , Y10T428/249953 , Y10T428/29 , Y10T428/2904 , Y10T428/2913 , Y10T428/2947 , Y10T428/31551
摘要： The present invention describes an aliphatic polyoxaamide polymer and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaamide of the present invention have a first divalent repeating unit of formula I:[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]Iand a second repeating unit selected from the group of formulas consisting of:[--Y--R.sub.17 --].sub.T, I[--O--R.sub.5 --C(O)--].sub.B, and II([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --O-- and may be blended with a second polymer that is preferably biocompatable.
摘要翻译： 本发明描述了可用于生产手术装置如缝合线，具有连接针的缝合线，模制装置等的脂族聚氧酰胺聚合物及其共混物。 本发明的脂族聚氧酰胺具有式I的第一个二价重复单元：[XC（O）-C（R1）（R2）-O-（R3）-OC（R1）（R2）-C（O） - ]和第二重复单元，其选自由以下组成的组：[-Y-R17-] T，I [-O-R 5 -C（O） - ] B和II（[-O-R 9 -C（O ）] PO-）LGXI及其组合，其中X和Y选自-O-和-N（R） - ，只要X和Y都不为-O-，并且可以与第二聚合物 这是优选生物相容的。
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公开(公告)号：US5486197A
公开(公告)日：1996-01-23
申请号：US216997
申请日：1994-03-24
CPC分类号： A61B17/0401 , A61B2017/0424 , A61B2017/06057
摘要： A two-piece suture anchor is disclosed wherein a barrel-like main portion is provided with a pair of legs in a central opening. A ball-like actuating device is received within the central opening and drawn upward into the device in order to separate the legs and cause the device to expand into the soft cancellous bone of a previously prepared bone site.
摘要翻译： 公开了一种两件式缝合锚，其中一个桶形主要部分在中央开口中设有一对腿。 球状致动装置被容纳在中央开口内并向上拉入装置中，以分离腿部并使装置膨胀成先前准备的骨部位的软质松质骨。
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公开(公告)号：US5464929A
公开(公告)日：1995-11-07
申请号：US399308
申请日：1995-03-06
IPC分类号： A61L17/00 , A61K9/22 , A61L15/22 , A61L15/26 , A61L15/60 , A61L17/10 , A61L27/00 , A61L27/18 , A61L27/52 , A61L29/04 , A61L29/06 , A61L29/14 , A61L31/04 , A61L31/06 , C08G63/66 , C08G63/664 , C08G63/672 , C08G69/40 , C08G69/44 , C08L67/00 , C08L101/16 , C09D167/00
CPC分类号： C08L67/00 , A61L15/225 , A61L15/26 , A61L15/60 , A61L17/105 , A61L27/18 , A61L27/52 , A61L29/049 , A61L29/06 , A61L29/145 , A61L31/041 , A61L31/06 , C08G63/664 , C08G63/672 , C08G69/40 , C08G69/44 , C09D167/00
摘要： The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--]Iand a second repeating unit selected from the group of formulas consisting of: ##STR1## and combinations thereof.
摘要翻译： 本发明描述了一种新的脂族聚氧化酯，其是生物可吸收的并且可用于生产外科装置，例如缝合线，具有连接针的缝合线，模制装置等。 本发明还考虑了制备这些聚酯的方法。 本发明的脂族聚氧酸酯具有式I的第一个二价重复单元：[OC（O）-C（R 1）（R 2）-O-（R 3）-OC（R 1）（R 2）-C（O） ]和第二重复单元，其选自由以下组成的组式：III和（[OR5C（O）] pO）LG XI及其组合。
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