公开(公告)号：US20070100222A1

公开(公告)日：2007-05-03

申请号：US11633254

申请日：2006-12-04

申请人： John Mastrototaro ,  Rajiv Shah ,  Partha Ray ,  Kenny Long ,  Andrew Hayes ,  Nandita Patel ,  Cary Talbot ,  Bahar Reghabi

发明人： John Mastrototaro ,  Rajiv Shah ,  Partha Ray ,  Kenny Long ,  Andrew Hayes ,  Nandita Patel ,  Cary Talbot ,  Bahar Reghabi

IPC分类号： A61B5/00 ,  G06Q10/00

CPC分类号： A61M5/14244 ,  A61B5/01 ,  A61B5/031 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/412 ,  A61B5/413 ,  A61B2562/0295 ,  A61M2005/1405 ,  A61M2205/18 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/52 ,  A61M2205/587 ,  A61M2230/201 ,  G06F19/3418 ,  G06Q50/22 ,  G16H40/20

摘要： A system is provided for monitoring blood glucose data of a patient. The system includes a sensing device and hospital monitor. The sensing device includes a sensor and sensor electronics and is adapted to transmit information to the hospital monitor while continuing to sense blood glucose data. The communication between the sensing device and the hospital monitor may be wireless. The sensor electronics may include a sensor power supply, a voltage regulator, and optionally a memory and processor.

摘要翻译： 提供一种用于监测患者血糖数据的系统。 该系统包括感测装置和医院监护仪。 感测装置包括传感器和传感器电子装置，并且适用于在继续感测血糖数据的同时向医院监护仪发送信息。 感测装置和医院监视器之间的通信可以是无线的。 传感器电子器件可以包括传感器电源，电压调节器以及可选地的存储器和处理器。

公开(公告)号：US20120227737A1

公开(公告)日：2012-09-13

申请号：US13472117

申请日：2012-05-15

申请人： JOHN J. MASTROTOTARO ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

发明人： JOHN J. MASTROTOTARO ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

IPC分类号： A61M5/31 ,  A61M5/307 ,  A61M15/00

CPC分类号： G06F19/3456 ,  G16H40/63

摘要： An analyte sensor and systems for determining analyte levels in a user's body. The analyte sensor and systems are adapted to be used with single dose medication devices and include a communication system to transmit the communications from the analyte sensor to the user to notify the user of an estimated amount of fluid to deliver to the user's body. More particularly, these apparatuses and methods for use are for providing convenient monitoring of blood glucose levels in determining the appropriate amount of insulin to deliver.

摘要翻译： 分析物传感器和用于确定用户身体中的分析物水平的系统。 分析物传感器和系统适于与单剂量药物装置一起使用，并且包括通信系统，用于将来自分析物传感器的通信传输给用户，以向使用者通报估计量的流体以递送给使用者的身体。 更具体地，这些使用的装置和方法用于在确定适当量的胰岛素输送时提供对血糖水平的便利监测。

公开(公告)号：US20080139910A1

公开(公告)日：2008-06-12

申请号：US11634728

申请日：2006-12-06

申请人： John J. Mastrototaro ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

发明人： John J. Mastrototaro ,  Rajiv Shah ,  Partha Ray ,  Kenny J. Long ,  Andrew C. Hayes ,  Nandita Patel ,  Cary D. Talbot ,  Bahar Reghabi

IPC分类号： A61B5/145

CPC分类号： G06F19/3456 ,  G16H40/63

摘要： An analyte sensor and systems for determining analyte levels in a user's body. The analyte sensor and systems are adapted to be used with single dose medication devices and include a communication system to transmit the communications from the analyte sensor to the user to notify the user of an estimated amount of fluid to deliver to the user's body. More particularly, these apparatuses and methods for use are for providing convenient monitoring of blood glucose levels in determining the appropriate amount of insulin to deliver.

摘要翻译： 分析物传感器和用于确定用户身体中的分析物水平的系统。 分析物传感器和系统适于与单剂量药物装置一起使用，并且包括通信系统，用于将来自分析物传感器的通信传输给用户，以向使用者通报估计量的流体以递送给使用者的身体。 更具体地，这些使用的装置和方法用于在确定适当量的胰岛素输送时提供对血糖水平的便利监测。

公开(公告)号：US20050272989A1

公开(公告)日：2005-12-08

申请号：US10861837

申请日：2004-06-04

申请人： Rajiv Shah ,  Bahar Reghabi ,  Rebecca Gottlieb ,  Udo Hoss ,  John Mastrototaro

发明人： Rajiv Shah ,  Bahar Reghabi ,  Rebecca Gottlieb ,  Udo Hoss ,  John Mastrototaro

IPC分类号： A61B5/00 ,  C12Q1/00 ,  C12Q1/26 ,  G01N27/30 ,  G01N33/49 ,  A61B5/05 ,  G01N27/26 ,  G01N33/50

CPC分类号： C12Q1/006 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/005 ,  C12Q1/26 ,  G01N33/4905

摘要： Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings.

摘要翻译： 本发明的实施方案提供了具有稳定的涂料组合物的分析物传感器和用于制造和使用这种传感器 示例性实施方案包括具有稳定的葡萄糖氧化酶涂层的电化学葡萄糖传感器。

公开(公告)号：US20070079836A1

公开(公告)日：2007-04-12

申请号：US11610269

申请日：2006-12-13

申请人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

发明人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

IPC分类号： A61B19/00

CPC分类号： A61B5/14532 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61M39/0208

摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.

摘要翻译： 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。 优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。 此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。

公开(公告)号：US09759678B2

公开(公告)日：2017-09-12

申请号：US12887460

申请日：2010-09-21

申请人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz

发明人： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC分类号： A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

CPC分类号： G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US08137927B2

公开(公告)日：2012-03-20

申请号：US11122172

申请日：2005-05-04

申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

IPC分类号： C12Q1/26 ,  C12Q1/54 ,  C12N11/02 ,  C12M1/34

CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

公开(公告)号：US20110130988A1

公开(公告)日：2011-06-02

申请号：US13004677

申请日：2011-01-11

申请人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

发明人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC分类号： G06F19/00 ,  G01R27/28

摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

公开(公告)号：US20110101995A1

公开(公告)日：2011-05-05

申请号：US13004660

申请日：2011-01-11

申请人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

发明人： RAJIV SHAH ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC分类号： G06F19/00 ,  G01R35/00

摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

公开(公告)号：US20090081753A1

公开(公告)日：2009-03-26

申请号：US12179502

申请日：2008-07-24

申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudolph A. Montalvo ,  Yanan Zhang

发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudolph A. Montalvo ,  Yanan Zhang

IPC分类号： C12N11/02 ,  B28B1/14 ,  C12M1/34 ,  C07K14/00

CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。