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    Method and apparatus for drug product tracking using encoded optical identification elements
    1.
    发明申请
    Method and apparatus for drug product tracking using encoded optical identification elements 有权
    使用编码的光学识别元件的药物产品跟踪的方法和装置

    公开(公告)号：US20060028727A1

    公开(公告)日：2006-02-09

    申请号：US11187262

    申请日：2005-07-21

    申请人： John Moon ,  Martin Putnam ,  Alan Kersey ,  David Fournier ,  Joseph Pinto

    发明人： John Moon ,  Martin Putnam ,  Alan Kersey ,  David Fournier ,  Joseph Pinto

    IPC分类号： G02B5/18

    CPC分类号： G06K19/06009 ,  G03H1/0011 ,  G03H2001/0016 ,  G06K19/16 ,  G06K2019/0629 ,  G07D7/0032 ,  G07D7/128

    摘要： A method and apparatus for drug product tracking (or other pharmaceutical, health care or cosmetics products, and/or the packages or containers they are supplied with) using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The encoded element 8 may be used to label any desired item, such as drugs or medicines, or other pharmaceutical or health care products or cosmetics. The label may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products. Such labeling provides product identification at the pill or liquid medicine level, which provides traceability of these products to their manufacturer, thereby reducing counterfeit products in the marketplace. Also, the elements 8 may be incorporated into a film, liquid, coating or adhesive tape at attached to the product package.

    摘要翻译： 使用基于衍射光栅的编码光学识别元件8的药物追踪（或其他药物，保健或化妆品产品和/或其提供的包装或容器）的方法和装置包括具有至少一个 设置在其中的衍射光栅12。 光栅12具有一个或多个共同定位的间距Lambda，其表示当被入射光24照射时检测到的唯一识别数字码。 入射光24可以从具有窄带（单波长）或多个波长源的基板10的一侧（或从一端）横向引导，并且代码由光或波长光谱的空间分布表示， 或其组合。 编码元件8可以用于标记任何期望的物品，例如药物或药物，或其它药物或保健产品或化妆品。 该标签可用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。 在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。 这种标签在药丸或液体药物级别提供产品鉴定，这些产品可以向制造商提供可追溯性，从而减少市场上的假冒产品。 此外，元件8可以结合到附接到产品包装上的膜，液体，涂层或胶带中。

    Optical reader for diffraction grating-based encoded optical identification elements
    2.
    发明申请
    Optical reader for diffraction grating-based encoded optical identification elements 有权
    用于衍射光栅编码光学识别元件的光学读取器

    公开(公告)号：US20060071075A1

    公开(公告)日：2006-04-06

    申请号：US10956791

    申请日：2004-10-01

    申请人： John Moon ,  David Fournier ,  Martin Putnam ,  Alan Kersey ,  Tuo Li

    发明人： John Moon ,  David Fournier ,  Martin Putnam ,  Alan Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  B01J2219/005 ,  B01J2219/0056 ,  G06K7/1094 ,  G06K19/06009 ,  G06K2019/06225 ,  G06K2019/06234 ,  G06K2019/0629 ,  G07D7/0032 ,  G07D7/004

    摘要： An optical reader system 7 for diffraction grating-based encoded microbeads (or bead reader system), comprises a reader box 100, which accepts a bead cell (or cuvette) 102 that holds the microbeads 8, having an embedded code therein. The reader box 100 interfaces along lines 103 with a known computer system 104. The reader box 100 interfaces with a stage position controller 112 and the controller 112 interfaces along a line 115 with the computer system 104 and a manual control device (or joy stick) 116 along a line 117. The reader interrogates the microbeads to determine the embedded code and/or the fluorescence level on the beads. The reader provides information similar to a bead flow cytometer but in a planar format, i.e., a virtual cytometer.

    摘要翻译： 用于基于衍射光栅的编码微珠（或珠读取器系统）的光学读取器系统7包括读取器盒100，其接收保持微珠8的珠细胞（或比色杯）102，其中具有嵌入代码。 读取器箱100沿着线103与已知的计算机系统104相接口。读取箱100与平台位置控制器112连接，并且控制器112沿着线115与计算机系统104和手动控制装置（或操纵杆） 116.读取器询问微珠以确定珠上的嵌入代码和/或荧光水平。 读者提供类似于珠流式细胞仪的信息，但是以平面格式，即虚拟血细胞计数器。

    Optical identification element using separate or partially overlapped diffraction gratings
    4.
    发明申请
    Optical identification element using separate or partially overlapped diffraction gratings 审中-公开
    使用单独或部分重叠的衍射光栅的光学识别元件

    公开(公告)号：US20060023310A1

    公开(公告)日：2006-02-02

    申请号：US11063666

    申请日：2005-02-22

    申请人： Martin Putnam ,  John Moon ,  Alan Kersey

    发明人： Martin Putnam ,  John Moon ,  Alan Kersey

    IPC分类号： G02B5/18

    CPC分类号： G02B5/1842 ,  G02B3/06

    摘要： An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches Λ which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.

    摘要翻译： 光学识别元件8包括其中设置有至少一个衍射光栅12的光学基板10。 光栅12具有一个或多个并置的间距λ，它们表示当被入射光24照射时检测到的唯一识别N位数字码。 入射光24可以以窄带（单波长）或多个波长源横向地引导到基板10的一侧或一端上，在这种情况下，代码由光或波长光谱的空间分布表示， 分别。 元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。 元件8可用于任何需要排序，标记，跟踪或识别的应用中，如果需要，可以在微米尺度“微珠”上制造，或者对于更大的应用可以使用更大的“宏观元件”。 代码可以是数字二进制的，也可以是其他的数字基础。

    Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
    5.
    发明申请
    Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction 有权
    使用以X射线衍射为特征的光学识别元件进行标记的方法和装置

    公开(公告)号：US20070121181A1

    公开(公告)日：2007-05-31

    申请号：US11601584

    申请日：2006-11-16

    申请人： John Moon ,  Martin Putnam ,  Alan Kersey ,  Paul Szczepanek

    发明人： John Moon ,  Martin Putnam ,  Alan Kersey ,  Paul Szczepanek

    IPC分类号： G03H1/00

    CPC分类号： G03H5/00 ,  G01N23/2005 ,  G03H2001/0016 ,  G07D7/003

    摘要： An optical identification element for identifying an item comprises a binder material and one or more materials embedded in the binder material. The one or more materials provide an encoded composite X-ray diffraction pattern when illuminated by an X-ray beam. The encoded composite X-ray diffraction pattern is indicative of the item. The one or more materials are preferably powdered crystal materials. The optical identification element may be shaped as a microbead or a macrobead. Alternatively, the binder material may be in the form of a thread or fiber. The labeled item may be selected from the group, comprising: large or small objects, products, solids, powders, liquids, gases, plants, pharmaceuticals, currency, ID cards, minerals, cells and/or animals. The item may be a chemical or a DNA sequence. The optical identification element may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products.

    摘要翻译： 用于识别物品的光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。 一种或多种材料在由X射线束照射时提供编码的复合X射线衍射图案。 编码的复合X射线衍射图表示该项目。 一种或多种材料优选为粉末状晶体材料。 光学识别元件可以成形为微珠或大珠粒。 或者，粘合剂材料可以是线或纤维的形式。 标签物品可以从组中选择，包括：大或小物体，产品，固体，粉末，液体，气体，植物，药物，货币，身份证，矿物质，细胞和/或动物。 该物品可以是化学物质或DNA序列。 光学识别元件可以用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。 在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。

    Optical identification element using separate or partially overlapped diffraction gratings
    6.
    发明申请
    Optical identification element using separate or partially overlapped diffraction gratings 审中-公开
    使用单独或部分重叠的衍射光栅的光学识别元件

    公开(公告)号：US20050270603A1

    公开(公告)日：2005-12-08

    申请号：US11158782

    申请日：2005-06-21

    申请人： Martin Putnam ,  John Moon ,  Alan Kersey

    发明人： Martin Putnam ,  John Moon ,  Alan Kersey

    IPC分类号： G03H1/00 ,  G03H1/26

    CPC分类号： G03H1/26 ,  G03H2001/0016 ,  G03H2230/10

    摘要： An optical identification element 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has a one or more of collocated pitches A which represent a unique identification N bit digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely onto the side or onto an end of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The element 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The element 8 can be used in any application that requires sorting, tagging, tracking or identification, and can be made on a micron scale “microbeads” if desired, or larger “macro-elements” for larger applications. The code may be digital binary or may be other numerical bases.

    摘要翻译： 光学识别元件8包括其中设置有至少一个衍射光栅12的光学基板10。 光栅12具有一个或多个并置间距A，其表示当被入射光24照射时检测到的唯一识别N位数字码。 入射光24可以以窄带（单波长）或多个波长源横向地引导到基板10的一侧或一端上，在这种情况下，代码由光或波长光谱的空间分布表示， 分别。 元件8可以提供大量独特的代码，例如大于6700万个代码，并且可以承受恶劣的环境。 元件8可用于任何需要排序，标记，跟踪或识别的应用中，如果需要，可以在微米尺度“微珠”上制造，或者对于更大的应用可以使用更大的“宏观元件”。 代码可以是数字二进制的，也可以是其他的数字基础。

    Optical channel monitor
    7.
    发明授权
    Optical channel monitor 有权
    光通道监视器

    公开(公告)号：US07463828B2

    公开(公告)日：2008-12-09

    申请号：US10159370

    申请日：2002-05-31

    申请人： John Moon ,  Ralph Jones ,  Charles Winston ,  James Sirkis ,  David Fournier ,  Joseph Pinto ,  Robert Brucato ,  James Dunphy ,  Christopher Chestnut

    发明人： John Moon ,  Ralph Jones ,  Charles Winston ,  James Sirkis ,  David Fournier ,  Joseph Pinto ,  Robert Brucato ,  James Dunphy ,  Christopher Chestnut

    IPC分类号： G02B6/26 ,  H01S3/08 ,  G01J3/18

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/32 ,  G01J3/36 ,  G01J2003/064 ,  G01J2003/1819 ,  G02B6/2706 ,  G02B6/2793 ,  G02B6/2931 ,  G02B6/29313 ,  G02B6/29314 ,  G02B6/29385 ,  G02B6/29398 ,  G02B6/3512 ,  G02B6/359 ,  G02B6/4215 ,  G02B6/4246 ,  H04B10/077 ,  H04B10/07955 ,  H04Q2011/0026 ,  H04Q2011/0049 ,  H04Q2011/0083

    摘要： An optical channel monitor is provided that sequentially or selectively filters an optical channel(s) 11 of light from a (WDM) optical input signal 12 and senses predetermined parameters of the each filtered optical signal (e.g., channel power, channel presence, signal-noise-ratio). The OCM 10 is a free-space optical device that includes a collimator assembly 15, a diffraction grating 20 and a mirror 22. A launch pigtail emits into free space the input signal through the collimator assembly 15 and onto the diffraction grating 20, which separates spatially each of the optical channels 11 of the collimated light, and reflects the separated channels of light onto the mirror 22. A λ/4 plate 26 is disposed between the mirror 22 and the diffraction grating 20. The mirror reflects the separated light back through the λ/4 plate 26 to the diffraction grating 20, which reflects the channels of light back through the collimating lens 18. The lens 18 focuses each separated channel of light (λ1-λN) at a different focal point in space. One of the optical channels 11 is focused onto a receive pigtail 28, which then propagates to a photodetector 30. A pivoting mechanism 34 pivots the diffraction grating 20 or mirror 22 about a pivot point 36 to sequentially or selectively focus each optical channel 11 to the receive pigtail 28. A position sensor 42 detects the displacement of the diffraction grating 24 or mirror.

    摘要翻译： 提供了一种光通道监视器，其顺序地或选择性地对来自（WDM）光输入信号12的光的通道11进行滤波，并且感测每个滤波的光信号的预定参数（例如，信道功率，信道存在， 噪声比）。 OCM 10是包括准直器组件15，衍射光栅20和反射镜22的自由空间光学装置。发射尾纤通过准直器组件15和衍射光栅20将衍射光栅20发射到自由空间中，输入信号分离 准直光的每个光通道11，并将分离的光反射到反射镜22上.λ/ 4板26设置在反射镜22和衍射光栅20之间。反射镜将分离的光反射回 λ/ 4板26到衍射光栅20，其反射通过准直透镜18的光通道。透镜18将每个分离的光（λ1-λN）通道在空间中的不同焦点处聚焦。 光通道11中的一个被聚焦到接收引线28上，接收引线28然后传播到光电检测器30.枢转机构34围绕枢转点36枢转衍射光栅20或反射镜22，以顺序地或选择性地将每个光通道11聚焦到 接收尾纤28.位置传感器42检测衍射光栅24或反射镜的位移。

    Multi-well plate with alignment grooves for encoded microparticles
    10.
    发明申请
    Multi-well plate with alignment grooves for encoded microparticles 审中-公开
    具有用于编码微粒的对准槽的多孔板

    公开(公告)号：US20060160208A1

    公开(公告)日：2006-07-20

    申请号：US11063665

    申请日：2005-02-22

    申请人： Martin Putnam ,  James Sirkis ,  John Moon ,  Tuo Li ,  Joseph Traynor ,  Robert Brucato

    发明人： Martin Putnam ,  James Sirkis ,  John Moon ,  Tuo Li ,  Joseph Traynor ,  Robert Brucato

    IPC分类号： C12M1/34 ,  G06K7/00 ,  G01N33/551 ,  C12M3/00

    CPC分类号： G01N33/54313 ,  G01N33/54393

    摘要： A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positioning device so the longitudinal axis of the microbeads is positioned in a fixed orientation relative to the code reading device. The microbeads are typically cylindrically shaped glass beads between 25 and 250 microns (μm) in diameter and between 100 and 500 μm long, and have a holographic code embedded in the central region of the bead, which is used to identify it from the rest of the beads in a batch of beads with many different chemical probes. A cross reference is used to determine which probe is attached to which bead, thus allowing the researcher to correlate the chemical content on each bead with the measured fluorescence signal. Because the code consists of a diffraction grating typically disposed along an axis, there is a particular alignment required between the incident readout laser beam and the readout detector in two of the three rotational axes. The third axis, rotation about the center axis of the cylinder, is azimuthally symmetric and therefore does not require alignment.

    摘要翻译： 提供了一种用于对准光学元件或微珠的方法和装置，其中每个微珠具有细长体，其沿着其纵向轴线嵌入其中的代码，以被代码读取装置读取。 微珠与定位装置对准，使得微珠的纵向轴线相对于代码读取装置定位成固定的取向。 微珠通常为直径为25至250微米（母体）和长度为100至500毫米的圆柱形玻璃珠，并且具有嵌入珠的中心区域中的全息代码，其用于从其余部分识别它 珠子中有一批具有许多不同化学探针的珠粒。 交叉参考用于确定哪个探针连接到哪个珠，从而允许研究者将每个珠上的化学成分与测量的荧光信号相关联。 由于代码由通常沿轴线设置的衍射光栅组成，所以在三个旋转轴中的两个中存在入射读出激光束和读出检测器之间所需的特定对准。 第三轴，围绕气缸的中心轴的旋转是方位对称的，因此不需要对准。