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1.发明授权Non-A, non-B, non-C, non-D, non-E Hepatitis reagents and methods for their use 失效非A，非B，非C，非D，非E型肝炎试剂及其使用方法
公开(公告)号：US5981172A
公开(公告)日：1999-11-09
申请号：US417629
申请日：1995-04-06
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , Sheri L. Buijk , James Carl Erker , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , Sheri L. Buijk , James Carl Erker , Isa K. Mushahwar
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/29 , A61K39/395 , A61P1/16 , C07H21/04 , C07K14/02 , C07K14/08 , C07K14/10 , C07K14/18 , C07K16/10 , C12N5/10 , C12N15/09 , C12N15/40 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , C12R1/92 , G01N33/531 , G01N33/566 , G01N33/576 , G01N33/577 , C07H21/02
CPC分类号： C07K14/005 , C12Q1/707 , G01N33/576 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022
摘要： Hepatitus GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and theraeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
摘要翻译： 用于各种诊断和应用应用的肝癌GB病毒（HGBV）核酸和氨基酸序列，使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒和特异性结合HGBV的抗体。 还提供了从HGBV核酸或氨基酸序列产生抗体，多克隆或单克隆抗体的方法。
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公开(公告)号：US6051374A
公开(公告)日：2000-04-18
申请号：US488445
申请日：1995-06-07
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
IPC分类号： A61K39/00 , C07K14/18 , C07K16/10 , C12Q1/70 , G01N33/576 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C07K14/005 , C07K16/109 , C12Q1/707 , G01N33/576 , A61K39/00 , C07K2319/00 , C12N2770/24222 , Y10S435/81 , Y10S530/826 , Y10S977/906 , Y10S977/915
摘要： Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
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公开(公告)号：US06558898B1
公开(公告)日：2003-05-06
申请号：US08488446
申请日：1995-06-07
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576 , Y10S435/81 , Y10S530/826 , Y10S977/906 , Y10S977/915
摘要： Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
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4.发明授权Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use 失效非A，非B，非C，非D，非E型肝炎试剂及其使用方法公开(公告)号：US06451578B1
公开(公告)日：2002-09-17
申请号：US08469260
申请日：1995-06-06
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576 , Y10S436/82 , Y10S977/803
摘要： Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
摘要翻译： 用于各种诊断和治疗应用的乙型肝炎病毒（HGBV）核酸和氨基酸序列，用于使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒和特异性结合HGBV的抗体。 还提供了从HGBV核酸或氨基酸序列产生抗体，多克隆或单克隆抗体的方法。
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5.发明授权Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use 失效非a，非b，非c，非c，非d，非e型肝炎试剂及其使用方法公开(公告)号：US06720166B2
公开(公告)日：2004-04-13
申请号：US08424550
申请日：1995-06-05
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
IPC分类号： C12P2102
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576
摘要： Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
摘要翻译： 用于各种诊断和治疗应用的乙型肝炎病毒（HGBV）核酸和氨基酸序列，用于使用HGBV核酸或氨基酸序列的试剂盒，HGBV免疫原性颗粒和特异性结合HGBV的抗体。 还提供了从HGBV核酸或氨基酸序列产生抗体，多克隆或单克隆抗体的方法。
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公开(公告)号：US06586568B1
公开(公告)日：2003-07-01
申请号：US08467344
申请日：1995-06-06
申请人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
发明人： John N. Simons , Tami J. Pilot-Matias , George J. Dawson , George G. Schlauder , Suresh M. Desai , Thomas P. Leary , Anthony Scott Muerhoff , James Carl Erker , Sheri L. Buijk , Isa K. Mushahwar
IPC分类号： C07K700
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/576 , Y10S435/81 , Y10S530/826 , Y10S977/906 , Y10S977/915
摘要： Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV immunogenic particles, and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV nucleic acid or amino acid sequences.
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公开(公告)号：US6156495A
公开(公告)日：2000-12-05
申请号：US629463
申请日：1996-04-19
申请人： Tami J. Pilot-Matias , Thomas P. Leary , John N. Simons , Robert J. Carrick , Teresa K. Surowy , Suresh M. Desai , George J. Dawson , Anthony Scott Muerhoff , Isa K. Mushahwar
发明人： Tami J. Pilot-Matias , Thomas P. Leary , John N. Simons , Robert J. Carrick , Teresa K. Surowy , Suresh M. Desai , George J. Dawson , Anthony Scott Muerhoff , Isa K. Mushahwar
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/29 , A61P31/12 , C07H21/02 , C07H21/04 , C07K14/02 , C07K14/08 , C07K14/10 , C07K14/18 , C07K16/00 , C07K16/10 , C07K19/00 , C12N15/02 , C12N15/09 , C12N15/40 , C12P21/02 , C12P21/08 , C12Q1/70 , C12R1/91 , G01N33/536 , G01N33/569 , G01N33/576 , G01N33/577 , C12N15/00
CPC分类号： C07K14/005 , C12Q1/707 , G01N33/576 , G01N33/5767 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022 , Y10S530/826
摘要： Recombinantly produced hepatitis GB Virus (HGBV) amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV amino acid sequences and antibodies which specifically bind to HGBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGBV recombinantly produced amino acid sequences.
摘要翻译： 用于各种诊断和治疗应用的重组产生的乙型肝炎病毒（HGBV）氨基酸序列，使用特异性结合HGBV的HGBV氨基酸序列和抗体的试剂盒。 还提供了从HGBV重组产生的氨基酸序列产生抗体，多克隆或单克隆抗体的方法。
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公开(公告)号：US5807670A
公开(公告)日：1998-09-15
申请号：US580038
申请日：1995-12-21
申请人： Anthony Scott Muerhoff , John N. Simons , Thomas P. Leary , Larry Birkenmeyer , James C. Erker , Michelle Chalmers , George J. Dawson , Suresh M. Desai , Isa K. Mushahwar
发明人： Anthony Scott Muerhoff , John N. Simons , Thomas P. Leary , Larry Birkenmeyer , James C. Erker , Michelle Chalmers , George J. Dawson , Suresh M. Desai , Isa K. Mushahwar
IPC分类号： G01N33/566 , C07K14/18 , C12N15/09 , C12N15/113 , C12N15/86 , C12Q1/70 , G01N33/576
CPC分类号： C12N15/1131 , C07K14/005 , C12N15/86 , C12Q1/707 , C07K2319/00 , C12N2310/315 , C12N2310/3181 , C12N2310/33 , C12N2770/24222 , C12N2840/203 , C12Q1/6813
摘要： HGBV-C oligonucleotides from the 5' end of HGBV-C useful for the detection and genotyping of HGBV-C isolates. Also provided are assays which utilize these oligonucleotides.
摘要翻译： 来自HGBV-C的5'端的HGBV-C寡核苷酸可用于HGBV-C分离物的检测和基因分型。 还提供了利用这些寡核苷酸的测定法。
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9.发明授权Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof 有权编码来自间日疟原虫的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US08318897B2
公开(公告)日：2012-11-27
申请号：US13219802
申请日：2011-08-29
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony Scott Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony Scott Muerhoff
IPC分类号： G01N33/531 , C07K14/445 , A61K39/002
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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公开(公告)号：US07101683B2
公开(公告)日：2006-09-05
申请号：US09891983
申请日：2001-06-26
申请人： Dinesh O. Shah , George J. Dawson , Anthony Scott Muerhoff , Xingli Jiang , Robin A. Gutierrez , Thomas P. Leary , Suresh Desai , James L. Stewart
发明人： Dinesh O. Shah , George J. Dawson , Anthony Scott Muerhoff , Xingli Jiang , Robin A. Gutierrez , Thomas P. Leary , Suresh Desai , James L. Stewart
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/5767 , G01N2469/10 , G01N2469/20
摘要： The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.
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