公开(公告)号：US20150021339A1

公开(公告)日：2015-01-22

申请号：US14357418

申请日：2012-11-09

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

IPC分类号： B65D25/14

CPC分类号： B65D25/14 ,  A61J1/05 ,  A61M5/3129 ,  A61M2005/3109 ,  A61M2005/3131 ,  C23C16/045 ,  C23C16/30 ,  C23C16/36 ,  C23C16/401 ,  C23C16/507

摘要： A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

摘要翻译： 提供了一种通过PECVD在衬底表面上提供钝化层或pH保护涂层的方法，该方法包括从包含聚合气体的气态反应物产生等离子体。 钝化层或pH保护涂层的润滑性，钝化性，pH保护性，疏水性和/或阻隔性能通过设定前体进料中O 2与有机硅前体的比例和/或通过设定所用的功率来设定 用于产生等离子体。 特别地，提供了由该方法制成的钝化层或pH保护涂层。 还提供了通过该方法涂覆的药物包装，并且使用这种包装保护容器中包含的组合物免受包装表面的机械和/或化学作用而没有钝化层或pH保护涂层材料。

公开(公告)号：US20100298738A1

公开(公告)日：2010-11-25

申请号：US12779007

申请日：2010-05-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/315 ,  A61B5/153 ,  A61J1/14 ,  B65G37/00 ,  C23C16/50 ,  C23C16/00 ,  C23C16/40 ,  B05D3/00 ,  B05C13/00 ,  B05C11/00 ,  C12M1/00 ,  G01N7/00 ,  F16C33/00

CPC分类号： C23C16/50 ,  A61M5/31513 ,  B05D1/62 ,  B05D5/08 ,  B05D7/02 ,  B65D25/14 ,  C23C16/045 ,  C23C16/401 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N2033/0096 ,  Y10T428/24975 ,  Y10T428/31663

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了一种容器处理系统和容器检查装置和方法。

公开(公告)号：US09878101B2

公开(公告)日：2018-01-30

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/00 ,  A61M5/31 ,  A61M5/315

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

公开(公告)号：US08512796B2

公开(公告)日：2013-08-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N15/08 ,  G01N31/00 ,  G01N33/44 ,  G01M3/04 ,  B29D22/00 ,  B32B27/08

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US20120123345A1

公开(公告)日：2012-05-17

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/31 ,  A61J1/14

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

摘要翻译： 公开了一种包括由环烯烃聚合物（COP）树脂制成的容器，容器上的CVD涂层和包含至少一种蛋白质，肽和/或DNA序列的药物的包装。 还公开了处理容器的方法，例如提供润滑性或疏水性。 坐便器的内表面可以通过PECVD通过容器端口进行处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。

公开(公告)号：US20110252899A1

公开(公告)日：2011-10-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N33/00 ,  B05C11/00 ,  A61M5/315

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US20150126941A1

公开(公告)日：2015-05-07

申请号：US14399678

申请日：2013-05-09

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter Sagona ,  Christopher Weikart ,  Jacob Israelachvili

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter Sagona ,  Christopher Weikart ,  Jacob Israelachvili

IPC分类号： A61L31/08 ,  A61L31/10

CPC分类号： A61J1/1468 ,  A61J1/00 ,  A61J1/05 ,  A61J1/2096 ,  A61J2200/50 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/08 ,  A61M3/0262 ,  Y10T428/1383

摘要： A method for providing a saccharide based lubricating or protective coating or layer on a substrate surface is provided. In particular, a lubricity and/or protective coating or layer made by said method is provided. Pharmaceutical packages or other vessels coated by said method and the use of such pharmaceutical packages or other vessels protecting a compound or composition contained or received in said vessel with a protective coating against mechanical and/or chemical effects of the surface of the vessel without a protective coating material are also provided.

摘要翻译： 提供了一种在基材表面上提供基于糖的润滑或保护涂层或层的方法。 特别地，提供了由所述方法制成的润滑性和/或保护性涂层或层。 通过所述方法涂覆的药物包装或其他容器以及使用这种药物包装或其他容器保护在所述容器中包含或接收的化​​合物或组合物的保护涂层，以防止容器表面的机械和/或化学作用而没有保护 还提供涂料。

公开(公告)号：US07985188B2

公开(公告)日：2011-07-26

申请号：US12779007

申请日：2010-05-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Johathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Johathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61B5/00 ,  B65D81/00 ,  C08F2/46 ,  C08J7/18 ,  H05H1/00 ,  H05H1/24 ,  C23C14/14 ,  C23C14/16 ,  B05D3/14 ,  H01L21/469

CPC分类号： C23C16/50 ,  A61M5/31513 ,  B05D1/62 ,  B05D5/08 ,  B05D7/02 ,  B65D25/14 ,  C23C16/045 ,  C23C16/401 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N2033/0096 ,  Y10T428/24975 ,  Y10T428/31663

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了一种容器处理系统和容器检查装置和方法。

公开(公告)号：US5199635A

公开(公告)日：1993-04-06

申请号：US753855

申请日：1991-09-03

申请人： Robert S. Abrams ,  Joseph H. Miller ,  Paul R. Bird

发明人： Robert S. Abrams ,  Joseph H. Miller ,  Paul R. Bird

IPC分类号： B65D5/74

CPC分类号： B65D5/746 ,  B65D2101/0023

摘要： A container for holding pourable contents includes an exterior surface, an interior surface, an interior for holding contents and a reclosable pour spout mounted on the container. The pour spout includes a flange member having oppositely positioned first and second sides. An aperture extends through the flange member and the second side of the flange member is secured to the outer periphery of the wall of the container. An extension is connected to and extends axially away from the outer surface of the container and the extension has an aperture extending therethrough that communicates with the aperture in the flange member. A stem is connected to and extends axially away from the second side of the flange member. The stem has an aperture extending therethrough that communicates with the aperture in the flange member and the pour spout is positioned on the container such that the stem extends through the opening in the wall of the container and into the interior of the container. At least a portion of the stem is turned outwardly and toward the interior surface of the wall to which the flange member is secured to produce a mechanical engagement between the turned stem and the container which tends to resist any tendency of the pour spout to be pulled from the container.

摘要翻译： 用于容纳可倾倒内容物的容器包括外表面，内表面，用于容纳内容物的内部和安装在容器上的可再闭合倾倒口。 倾倒口包括具有相对定位的第一和第二侧面的凸缘构件。 孔径延伸穿过凸缘构件，并且凸缘构件的第二侧固定到容器的壁的外周。 延伸部连接到轴向远离容器的外表面并且延伸部具有延伸穿过其中的孔，其与凸缘构件中的孔连通。 杆与凸缘构件的第二侧连接并轴向延伸。 杆具有延伸穿过其中的孔，其与凸缘构件中的孔连通，并且倾倒口定位在容器上，使得杆延伸穿过容器的壁中的开口并进入容器的内部。 杆的至少一部分向外转动并朝向安装凸缘构件的壁的内表面，以在转向的杆和容器之间产生机械接合，倾向于抵抗倾倒口被拉动的任何倾向 从容器。

公开(公告)号：US4812116A

公开(公告)日：1989-03-14

申请号：US213846

申请日：1988-06-30

申请人： Robert S. Abrams

发明人： Robert S. Abrams

IPC分类号： B29C43/02 ,  B29C43/14 ,  B29C45/00 ,  B29C65/66 ,  B29C33/02 ,  B29C33/10 ,  B29C45/03 ,  B29C45/34

CPC分类号： B29C66/542 ,  B29C43/02 ,  B29C43/14 ,  B29C45/006 ,  B29C65/58 ,  B29C65/665 ,  B29C66/549 ,  B29C66/8221 ,  B29C66/8222 ,  B29C66/8324 ,  B29C2043/046 ,  B29C2043/3665 ,  B29L2031/565 ,  Y10S16/13 ,  Y10T16/525 ,  Y10T29/4987 ,  Y10T29/53657

摘要： The present invention relates to apparatus form making a vial and cap. A mold for forming the vial and cap and means for seating the cap on the vial prior to ejecting the vial from the mold is provided and includes a frame for the mold, a first mold half arranged on the frame, and a second mold half movably arranged relative to the first mold half so as to form a mold cavity therebetween. The mold produces a vial and cap including smooth radii provided at several locations to facilitate the seating of the cap on the vial.

摘要翻译： 本发明涉及制造小瓶和盖子的装置形式。 提供了用于形成小瓶和盖子的模具以及用于在从模具中弹出小瓶之前将盖子放置在小瓶上的装置，并且包括用于模具的框架，布置在框架上的第一模具半部和可移动的第二模具 相对于第一半模布置以在其间形成模腔。 该模具产生一个小瓶和帽子，包括在几个位置提供的平滑的半径，以便于把帽子放置在小瓶上。