公开(公告)号：US20150021339A1

公开(公告)日：2015-01-22

申请号：US14357418

申请日：2012-11-09

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona ,  Christopher Weikart

IPC分类号： B65D25/14

CPC分类号： B65D25/14 ,  A61J1/05 ,  A61M5/3129 ,  A61M2005/3109 ,  A61M2005/3131 ,  C23C16/045 ,  C23C16/30 ,  C23C16/36 ,  C23C16/401 ,  C23C16/507

摘要： A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the O2 to the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

摘要翻译： 提供了一种通过PECVD在衬底表面上提供钝化层或pH保护涂层的方法，该方法包括从包含聚合气体的气态反应物产生等离子体。 钝化层或pH保护涂层的润滑性，钝化性，pH保护性，疏水性和/或阻隔性能通过设定前体进料中O 2与有机硅前体的比例和/或通过设定所用的功率来设定 用于产生等离子体。 特别地，提供了由该方法制成的钝化层或pH保护涂层。 还提供了通过该方法涂覆的药物包装，并且使用这种包装保护容器中包含的组合物免受包装表面的机械和/或化学作用而没有钝化层或pH保护涂层材料。

公开(公告)号：US20100298738A1

公开(公告)日：2010-11-25

申请号：US12779007

申请日：2010-05-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/315 ,  A61B5/153 ,  A61J1/14 ,  B65G37/00 ,  C23C16/50 ,  C23C16/00 ,  C23C16/40 ,  B05D3/00 ,  B05C13/00 ,  B05C11/00 ,  C12M1/00 ,  G01N7/00 ,  F16C33/00

CPC分类号： C23C16/50 ,  A61M5/31513 ,  B05D1/62 ,  B05D5/08 ,  B05D7/02 ,  B65D25/14 ,  C23C16/045 ,  C23C16/401 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N2033/0096 ,  Y10T428/24975 ,  Y10T428/31663

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了一种容器处理系统和容器检查装置和方法。

公开(公告)号：US09878101B2

公开(公告)日：2018-01-30

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/00 ,  A61M5/31 ,  A61M5/315

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

公开(公告)号：US08512796B2

公开(公告)日：2013-08-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N15/08 ,  G01N31/00 ,  G01N33/44 ,  G01M3/04 ,  B29D22/00 ,  B32B27/08

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US20120123345A1

公开(公告)日：2012-05-17

申请号：US13240797

申请日：2011-09-22

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61M5/31 ,  A61J1/14

CPC分类号： A61M5/3129 ,  A61M5/31513 ,  A61M2005/3131

摘要： A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

摘要翻译： 公开了一种包括由环烯烃聚合物（COP）树脂制成的容器，容器上的CVD涂层和包含至少一种蛋白质，肽和/或DNA序列的药物的包装。 还公开了处理容器的方法，例如提供润滑性或疏水性。 坐便器的内表面可以通过PECVD通过容器端口进行处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。

公开(公告)号：US20110252899A1

公开(公告)日：2011-10-20

申请号：US13169811

申请日：2011-06-27

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Jonathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： G01N33/00 ,  B05C11/00 ,  A61M5/315

CPC分类号： A61B5/150206 ,  A61B5/154 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05C13/00 ,  B05C13/025 ,  B23Q7/04 ,  B23Q7/1494 ,  C23C16/045 ,  C23C16/401 ,  C23C16/458 ,  C23C16/50 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N23/2273 ,  G01N30/7206 ,  G01N33/00 ,  G01N2033/0096 ,  Y10T428/13 ,  Y10T428/1383

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed, for example using material outgassed from a surface to inspect the properties of a surface coating.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了容器处理系统和容器检查装置和方法，例如使用从表面去除的材料来检查表面涂层的性质。

公开(公告)号：US07985188B2

公开(公告)日：2011-07-26

申请号：US12779007

申请日：2010-05-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Johathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

发明人： John T. Felts ,  Thomas E. Fisk ,  Robert S. Abrams ,  John Ferguson ,  Johathan R. Freedman ,  Robert J. Pangborn ,  Peter J. Sagona

IPC分类号： A61B5/00 ,  B65D81/00 ,  C08F2/46 ,  C08J7/18 ,  H05H1/00 ,  H05H1/24 ,  C23C14/14 ,  C23C14/16 ,  B05D3/14 ,  H01L21/469

CPC分类号： C23C16/50 ,  A61M5/31513 ,  B05D1/62 ,  B05D5/08 ,  B05D7/02 ,  B65D25/14 ,  C23C16/045 ,  C23C16/401 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01N15/082 ,  G01N2033/0096 ,  Y10T428/24975 ,  Y10T428/31663

摘要： Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system and vessel inspection apparatus and methods are also disclosed.

摘要翻译： 公开了处理容器的方法，例如提供阻气或润滑性。 提供第一和第二PECVD或其他容器加工站或装置以及包括容器端口的容器保持器。 船只的开口可以坐在船只港口上。 坐便器的内表面可以通过第一和第二处理站或设备经容器端口处理。 公开了船舶屏障，润滑性和疏水涂层以及涂覆的容器，例如注射器和医用样品收集管。 还公开了一种容器处理系统和容器检查装置和方法。

公开(公告)号：US20130041241A1

公开(公告)日：2013-02-14

申请号：US13651299

申请日：2012-10-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

发明人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

IPC分类号： A61M5/31 ,  A61M5/178 ,  A61M5/30 ,  A61B5/145 ,  A61J7/00 ,  A61M15/00 ,  A61B6/00 ,  A61M35/00 ,  B05D7/22 ,  A61M5/315

CPC分类号： C23C16/401 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/154 ,  A61L31/08 ,  A61M5/3202 ,  B05D7/22 ,  C23C16/045 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01M3/329 ,  G01N2033/0096

摘要： A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

摘要翻译： 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括桶，任选地分配部分和盖的封盖预组件的筒的内壁的至少一部分上。 盖被固定到筒体上，并且至少基本上将分配部分的远端开口与帽外的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在施加步骤结束时，有效地保持通过前开口保持从筒内腔到外部的通信，任选地进一步经由分配部分腔（如果存在）进一步施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。

公开(公告)号：US09458536B2

公开(公告)日：2016-10-04

申请号：US13651299

申请日：2012-10-12

申请人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

发明人： John T. Felts ,  Thomas E. Fisk ,  Shawn Kinney ,  Christopher Weikart ,  Benjamin Hunt ,  Adrian Raiche ,  Brian Fitzpatrick ,  Peter J. Sagona ,  Adam Stevenson

IPC分类号： A61M25/00 ,  B05D3/00 ,  C23C16/40 ,  C23C16/04 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  A61B5/15 ,  A61B5/153 ,  A61B5/154 ,  A61M5/32 ,  G01M3/32 ,  B05D7/22 ,  A61L31/08 ,  G01N33/00

CPC分类号： C23C16/401 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150595 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153 ,  A61B5/154 ,  A61L31/08 ,  A61M5/3202 ,  B05D7/22 ,  C23C16/045 ,  C23C16/505 ,  C23C16/52 ,  C23C16/54 ,  G01M3/329 ,  G01N2033/0096

摘要： A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, optionally a dispensing portion, and a cap. The cap is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the cap. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication from the barrel lumen to the exterior via the front opening, optionally further via the dispensing portion lumen if present, at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

摘要翻译： 公开了一种方法，其中气相沉积的涂层或层直接或间接地施加到包括桶，任选地分配部分和盖的封盖预组件的筒的内壁的至少一部分上。 盖被固定到筒体上，并且至少基本上将分配部分的远端开口与帽外的压力条件隔离。 当预组件被盖住时，气相沉积的涂层或层直接或间接施加到筒的内壁的至少一部分。 在施加步骤结束时，有效地保持通过前开口保持从筒内腔到外部的通信，任选地进一步经由分配部分腔（如果存在）进一步施加涂层或层。 封盖预组件可以容易且快速地进行压力测试，例如在1至60秒之间的测试持续时间，以确定其是否具有容器封闭完整性。

公开(公告)号：US20080283184A1

公开(公告)日：2008-11-20

申请号：US10599247

申请日：2005-03-28

申请人： Peter J. Sagona ,  Jonathan R. Freedman ,  Jean Pierre Giraud

发明人： Peter J. Sagona ,  Jonathan R. Freedman ,  Jean Pierre Giraud

IPC分类号： B32B37/02 ,  B32B37/10

CPC分类号： B65D81/267 ,  B31B50/8122 ,  B65B61/20 ,  B65D75/326 ,  B65D81/2076 ,  B65D81/2084 ,  Y10T156/1052 ,  Y10T156/1062

摘要： The present invention relates to a method of attaching an active film (5) onto a flexible package comprising the steps of heating a foil (2); applying an active film (5) to the foil (2); and applying sufficient pressure to the active film (5) and foil (2) combination and sufficient heat to the foil (2) so that active film (5) adheres to the foil (2). In one example, the active film (5) comprises two components and wherein the two components are an active agent and a polymer. In another example, the active agent is an absorbing material.

摘要翻译： 本发明涉及一种将活性膜（5）附着在柔性包装上的方法，包括加热箔（2）的步骤; 将活性膜（5）施加到所述箔（2）上; 并向活性膜（5）和箔（2）施加足够的压力并将合金和足够的热量施加到箔（2），使得活性膜（5）粘附到箔（2）上。 在一个实例中，活性膜（5）包含两种组分，其中两种组分是活性剂和聚合物。 在另一个实例中，活性剂是吸收材料。