公开(公告)号：US5041283A

公开(公告)日：1991-08-20

申请号：US404409

申请日：1989-09-08

申请人： Katsumi Kita ,  Tetsuo Uno ,  Shinichi Masuda ,  Kazuyuki Yahagi ,  Kazuhiro Tashiro

发明人： Katsumi Kita ,  Tetsuo Uno ,  Shinichi Masuda ,  Kazuyuki Yahagi ,  Kazuhiro Tashiro

IPC分类号： C07C29/38 ,  A61K8/00 ,  A61K8/34 ,  A61Q5/00 ,  A61Q19/00 ,  C07C27/00 ,  C07C31/22 ,  C07C67/00

CPC分类号： A61K8/345 ,  A61Q19/00 ,  C07C31/22 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q19/10 ,  A61Q5/00 ,  A61Q5/06 ,  A61Q5/12

摘要： A cosmetic composition comprising a long-chain alkyltrimethylol is disclosed. The alkyltrimethylol is represeneted by the formula (I): ##STR1## wherein R is a linear or branched, saturated or unsaturated alkyl group having 8-22 carbon atoms. The composition is applied to various types of cosmetic and exhibits superior extendibility when applied, imparts a non-sticky, fresh feeling upon use, and provides an excellent moisture-retaining effect.

公开(公告)号：US20110262963A1

公开(公告)日：2011-10-27

申请号：US13125547

申请日：2009-10-23

申请人： Bernhard Geierstanger ,  Weijia Ou ,  Susan E. Cellitti ,  Tetsuo Uno ,  Tiffany Crossgrove ,  Hsien-Po Chiu ,  Jan Grunewald ,  Xueshi Hao

发明人： Bernhard Geierstanger ,  Weijia Ou ,  Susan E. Cellitti ,  Tetsuo Uno ,  Tiffany Crossgrove ,  Hsien-Po Chiu ,  Jan Grunewald ,  Xueshi Hao

IPC分类号： C12P21/02 ,  C07D207/22 ,  C07K16/00 ,  C12P21/08 ,  C07K14/485 ,  C12N11/18 ,  C12N9/90 ,  C07K14/50 ,  C07K14/525 ,  C07K14/435 ,  C07K14/505

CPC分类号： C12P21/00 ,  C07D207/20 ,  C07D207/48 ,  C07K5/0215

摘要： Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.

摘要翻译： 本文公开的是吡咯啉 - 羧基赖氨酸（PCL），吡咯赖氨酸类似物，其是天然的，生物合成产生的氨基酸，以及用于生物合成生成PCL的方法。 本文还公开了具有并入其中的PCL的蛋白质，多肽和肽以及将PCL并入此类蛋白质，多肽和肽的方法。 本文还公开了具有并入其中的PCL或吡咯赖胺的蛋白质，多肽和肽的位点特异性衍生化。 本文还公开了具有并入其中的PCL或吡咯赖氨酸的蛋白质，多肽和肽的交联。

公开(公告)号：US20110257154A1

公开(公告)日：2011-10-20

申请号：US13172357

申请日：2011-06-29

申请人： Pierre-Yves Michellys ,  Wei Pei ,  Thomas H. Marsilje ,  Wenshuo Lu ,  Bei Chen ,  Tetsuo Uno ,  Yunho Jin ,  Tao Jiang

发明人： Pierre-Yves Michellys ,  Wei Pei ,  Thomas H. Marsilje ,  Wenshuo Lu ,  Bei Chen ,  Tetsuo Uno ,  Yunho Jin ,  Tao Jiang

IPC分类号： A61K31/397 ,  A61K31/506 ,  C07D239/48 ,  A61K31/505 ,  C07D413/14 ,  A61K31/5377 ,  C07D413/12 ,  C07D403/12 ,  A61K31/496 ,  C07D487/04 ,  A61K31/519 ,  A61K31/52 ,  A61P31/00 ,  A61P35/00 ,  C12N5/09 ,  C07D401/14

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/74 ,  C07D239/48 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D451/02 ,  C07D453/02 ,  C07D471/04 ,  C07D473/16 ,  C07D487/04 ,  C07D487/08

摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.

公开(公告)号：US20110053897A1

公开(公告)日：2011-03-03

申请号：US12843771

申请日：2010-07-26

申请人： Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

发明人： Jianwei CHE ,  Bei Chen ,  Qiang Ding ,  Xueshi Hao ,  Xiaohui He ,  Songchun Jiang ,  Qihui Jin ,  Yunho Jin ,  Hong Liu ,  Yahua Liu ,  Barun Okram ,  Tetsuo Uno ,  Xu Wu ,  Kunyong Yang ,  Xuefeng Zhu

IPC分类号： A61K31/635 ,  C07D471/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/444 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  A61P7/06 ,  A61P25/00

CPC分类号： C07D471/04 ,  A61K31/4375

摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

摘要翻译： 本文提供了区域新颖的化合物类，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

公开(公告)号：US20080108616A1

公开(公告)日：2008-05-08

申请号：US11970278

申请日：2008-01-07

申请人： Qiang Ding ,  Nathanael Gray ,  Bing Li ,  Yi Liu ,  Tetsuo Uno

发明人： Qiang Ding ,  Nathanael Gray ,  Bing Li ,  Yi Liu ,  Tetsuo Uno

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/496 ,  C07D413/14 ,  C07D403/14 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2α and SAPK2β kinases.

摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症 ，Bmx，CSK，TrkB，FGFR3，Fes，Lck，B-RAF，C-RAF，MKK6，SAPK2alpha和SAPK2β激酶。

公开(公告)号：US20080068410A1

公开(公告)日：2008-03-20

申请号：US11901193

申请日：2007-09-14

申请人： Hiroaki Arakawa ,  Tetsuo Uno ,  Masakazu Mori

发明人： Hiroaki Arakawa ,  Tetsuo Uno ,  Masakazu Mori

IPC分类号： B41J29/38

CPC分类号： B41J2/04581 ,  B41J2/04521 ,  B41J2/04541 ,  B41J2/04573 ,  B41J2/0458

摘要： An inkjet head driving apparatus, wherein serial data indicating emission or non emission of nozzles respectively for a plurality of heads, is latched and memorized, and the nozzles are driven respectively based on the data memorized, the inkjet head driving apparatus having: an emission timing signal outputting device disposed in common for a plurality of heads so as to output a plurality of emission timing signals in one emission cycle; a setting device disposed respectively for the plurality of the heads so as to select the sequential emission timing signals at which emission starts synchronously, among the emission timing signals outputted from the emission timing signal outputting device in one emission cycle.

摘要翻译： 一种喷墨头驱动装置，其中分别指示用于多个头的喷嘴的发射或不发射的串行数据被锁存和存储，并且基于所记录的数据分别驱动喷嘴，该喷墨头驱动装置具有：发射定时 信号输出装置，用于多个头共用，以便在一个发射周期中输出多个发射定时信号; 在一个发射周期中，从发射定时信号输出装置输出的发射定时信号中，分别设置用于多个磁头的设定装置，以选择同步发射的顺序发射定时信号。

公开(公告)号：US20060119678A1

公开(公告)日：2006-06-08

申请号：US11286467

申请日：2005-11-25

申请人： Hiroaki Arakawa ,  Tetsuo Uno

发明人： Hiroaki Arakawa ,  Tetsuo Uno

IPC分类号： B41J2/185 ,  B41J29/38

CPC分类号： B41J2/04541 ,  B41J2/04586

摘要： There is described an image recording apparatus, which makes it possible to improve the operation efficiency of the host computer for high-speed image recording. The apparatus includes: a recording head having a plurality of ink emitting nozzles; a plurality of storing sections to store ink emitting data for every unit ink emitting action; a controller to selectively designate a specific storing section from the plurality of storing sections corresponding to a current progress status of ink emitting actions, and to sequentially read out the ink emitting data from the specific storing section for every unit ink emitting action, in order to depict the specific printing pattern; a shift register to sequentially store the ink emitting data, read by the controller, for every unit ink emitting action; and a head driving section to sequentially drive the recording head for every unit ink emitting action, based on the ink emitting data.

摘要翻译： 描述了一种图像记录装置，其可以提高用于高速图像记录的主计算机的操作效率。 该装置包括：具有多个喷墨喷嘴的记录头; 多个存储部，用于存储用于每个单位墨水排出动作的墨水发射数据; 一个控制器，用于根据当前的墨水排放动作的进展状态从多个存储部分中选择性地指定一个特定的存储部分，并且从每个单位的墨水喷射动作顺序读出来自特定的存储部分的墨水发射数据，以便 描述具体的印刷图案; 移位寄存器，用于顺序地存储由控制器读取的墨水排出数据，用于每单位墨水排出动作; 以及头驱动部，其基于发墨数据顺序地驱动用于每单位墨喷射动作的记录头。

公开(公告)号：US20050101525A1

公开(公告)日：2005-05-12

申请号：US10448902

申请日：2003-05-30

申请人： Ronald Zuckermann ,  Chin-Yi Huang ,  John Murphy ,  Tetsuo Uno

发明人： Ronald Zuckermann ,  Chin-Yi Huang ,  John Murphy ,  Tetsuo Uno

IPC分类号： C12N15/09 ,  A61K9/127 ,  A61K31/711 ,  A61K47/16 ,  A61K47/34 ,  A61K47/48 ,  A61K48/00 ,  C07C231/02 ,  C07C237/22 ,  C08G69/48 ,  C12N15/87 ,  C07K9/00

CPC分类号： C12N15/87 ,  A61K47/645

摘要： In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

摘要翻译： 根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送至靶位点的载体。 特别地，本发明化合物有利于促进将多核苷酸递送至细胞。 本发明还提供了用于制备与递送载体​​复合的多核苷酸的稳定制剂的方法。

公开(公告)号：US4990569A

公开(公告)日：1991-02-05

申请号：US223599

申请日：1988-07-25

申请人： Yasushi Okamoto ,  Tetsuo Uno

发明人： Yasushi Okamoto ,  Tetsuo Uno

IPC分类号： C08L51/04

CPC分类号： C08L51/04

摘要： A rubber-modified styrene resin composition is disclosed, in which a soft component comprising an elastomer is dispersed in a resin matrix comprising a styrene resin in the form of particles, wherein:(1) the soft component particles dispersed in the composition have an average particle size of from 0.2 to 2.6 .mu.m;(2) the soft component has such a particle size distribution as having two maxima, one in the range less than 0.8 .mu.m and the other in the range not less than 0.8 .mu.m;(3) the elastomer is present in an amount of from 5.0 to 10.0% by weight based on the resin composition; and(4) the resin matrix has an intrinsic viscosity [.eta.] of at least 0.65.The resin composition exhibits markedly improved impact strength, stiffness and gloss.

公开(公告)号：US09988420B2

公开(公告)日：2018-06-05

申请号：US15104727

申请日：2014-12-17

申请人： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang ,  Yunho Jin

发明人： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang ,  Yunho Jin

IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K7/02 ,  C07K16/32 ,  A61K47/68

CPC分类号： C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

摘要： Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.