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1.发明授权Crosslinked polymers, fine polymer particle, and process for producing these 失效交联聚合物，聚合物微粒，以及制造这些聚合物的方法公开(公告)号：US07129293B2
公开(公告)日：2006-10-31
申请号：US10512424
申请日：2003-04-23
申请人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Atsuhiko Ogura , Takehiko Ishii , Hisato Hayashi , Teppei Uno
发明人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Atsuhiko Ogura , Takehiko Ishii , Hisato Hayashi , Teppei Uno
IPC分类号： C08L47/00 , C08L132/00 , A61K9/14
CPC分类号： B22F1/0062 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C08F265/10 , C08F290/06 , C08F290/062 , C08L51/003 , C08L2666/02 , B22F1/0018 , B22F3/02
摘要： A crosslinked polymer or polymer fine particles which can be obtained through copolymerization of at least a macromonomer having a polyethylene glycol segment, a comonomer having tertiary amine groups in its side chains and a crosslinking agent are provided. Said crosslinked polymer can be provided in the form of polymer nano- or micro-spheres; and also as conjugate nano- or micro-spheres with their core parts fixing or encapsulating metal or semiconductor ultrafine particles.
摘要翻译： 提供了可以通过至少具有聚乙二醇部分的大分子单体，其侧链中具有叔胺基团的共聚单体和交联剂共聚获得的交联聚合物或聚合物细颗粒。 所述交联聚合物可以以聚合物纳米或微球的形式提供; 以及它们的核心部分固定或封装金属或半导体超细颗粒的共轭纳米或微球。
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2.发明授权公开(公告)号：US07122133B2
公开(公告)日：2006-10-17
申请号：US10363053
申请日：2001-02-14
CPC分类号： H01B1/22 , B22F1/0022 , B22F2998/00 , B82Y30/00 , Y10S977/813 , Y10S977/84
摘要： A stabilized dispersion of metal fine particles comprising, fine particles of metal which is obtained by reducing at least one metallic acid or salt thereof selected from the group consisting of haloauric acid, haloplatinic acid, silver nitrate and halorhodic acid by a reducing agent in the aqueous solution of (1) R-PEG-SX [R is a functional group selected from the group consisting of acetal, aldehyde, hydroxyl group, amino group, carboxyl group, active ester group, azide group, biotin group, monosaccharide, oligosaccharide, amino acid, nucleic acid, allyl group, vinyl benzyl group, methacryloyl group and acryloyl group, PEG is —(CH2CH2O)n—, X is H or pyridylthio group] or (2) R-PEG/PAMA (given structural formula A), and said fine particles load a polymer having PEG unit possessing above mentioned functional group on the surface.
摘要翻译： 金属微粒的稳定分散体，其包含金属微粒，其是通过还原剂还原至少一种金属酸或其盐，所述金属酸或其盐选自卤代月桂酸，卤铂酸，硝酸银和卤代罗丹酸 （1）R-PEG-SX的溶液[R是选自缩醛，醛，羟基，氨基，羧基，活性酯基，叠氮基，生物素基团，单糖，寡糖，氨基 酸，核酸，烯丙基，乙烯基苄基，甲基丙烯酰基和丙烯酰基，PEG是 - （CH 2 CH 2 CH 2 O） - ，X是H或吡啶硫基]或（2）R-PEG / PAMA（给定结构式A），并且所述细颗粒在表面上加载具有上述官能团的具有PEG单元的聚合物。
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3.发明申请Crosslinked polymers, fine polymer particle, and process for producing these 失效交联聚合物，聚合物微粒，以及制造这些聚合物的方法公开(公告)号：US20050171289A1
公开(公告)日：2005-08-04
申请号：US10512424
申请日：2003-04-23
申请人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Atsuhiko Ogura , Takehiko Ishii , Hisato Hayashi , Teppei Uno
发明人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Atsuhiko Ogura , Takehiko Ishii , Hisato Hayashi , Teppei Uno
IPC分类号： C08J3/205 , B22F1/00 , C08F2/22 , C08F212/14 , C08F216/14 , C08F220/26 , C08F220/34 , C08F220/60 , C08F265/10 , C08F290/06 , C08L51/00 , C08F2/00 , C08L83/00
CPC分类号： B22F1/0062 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C08F265/10 , C08F290/06 , C08F290/062 , C08L51/003 , C08L2666/02 , B22F1/0018 , B22F3/02
摘要： A crosslinked polymer or polymer fine particles which can be obtained through copolymerization of at least a macromonomer having a polyethylene glycol segment, a comonomer having tertiary amine groups in its side chains and a crosslinking agent are provided. Said crosslinked polymer can be provided in the form of polymer nano- or micro- spheres; and also as conjugate nano- or micro-spheres with their core parts fixing or encapsulating metal or semiconductor ultrafine particles.
摘要翻译： 提供了可以通过至少具有聚乙二醇部分的大分子单体，其侧链中具有叔胺基团的共聚单体和交联剂共聚获得的交联聚合物或聚合物细颗粒。 所述交联聚合物可以以聚合物纳米或微球的形式提供; 以及它们的核心部分固定或封装金属或半导体超细颗粒的共轭纳米或微球。
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4.发明申请公开(公告)号：US20050106570A1
公开(公告)日：2005-05-19
申请号：US10509576
申请日：2003-03-24
申请人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Katsumi Uchida , Takehiko Ishii , Yuko Suzuki , Yoshitsugu Akiyama , Seiji Takae
发明人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Katsumi Uchida , Takehiko Ishii , Yuko Suzuki , Yoshitsugu Akiyama , Seiji Takae
IPC分类号： B01J38/10 , G01N33/543 , G01N33/551 , G01N33/553 , C12Q1/68 , C08G63/48 , C08G63/91 , C12M1/34 , G01N33/53
CPC分类号： G01N33/54346 , B82Y15/00 , B82Y30/00 , G01N33/54393 , G01N33/551 , G01N33/553
摘要： The invention provides high sensitivity bioassay sensor systems in which non-specific adsorption of impurities such as, for example, proteins, in biological samples is inhibited. Polyethylene glycolated particles enclosing metal or semi-conductor which is in common with the sensor material are used for amplification.
摘要翻译： 本发明提供了高灵敏度的生物测定传感器系统，其中抑制了生物样品中杂质如蛋白质的非特异性吸附。 与传感器材料相同的封闭金属或半导体的聚乙烯糖基化颗粒用于扩增。
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公开(公告)号：US06927033B2
公开(公告)日：2005-08-09
申请号：US10275904
申请日：2001-05-10
IPC分类号： C08G63/688 , G01N21/41 , G01N33/543 , G01N33/544 , G01N33/545 , G01N33/53
CPC分类号： G01N33/545 , C08G63/688 , G01N33/54353 , G01N33/544 , Y10S435/817
摘要： A polymer composition is provided, which contains a polymer or copolymer having a mercapto group at one end and functional group or ligand at the other end and also having a polyethylene glycol segment. Such a composition can form a biosensor surface of reduced non-specific adsorbability for proteins and the like.
摘要翻译： 提供一种聚合物组合物，其包含在一端具有巯基的聚合物或共聚物，另一端具有官能团或配体，并且还具有聚乙二醇部分。 这种组合物可以形成对蛋白质等降低的非特异性吸附性的生物传感器表面。
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6.发明授权Cultured cell construct which contains spheroids of cultured animal cells and the use thereof 有权含有培养的动物细胞的球体的培养细胞构建体及其用途公开(公告)号：US07691369B2
公开(公告)日：2010-04-06
申请号：US12230916
申请日：2008-09-08
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译： 将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。 因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。 该培养物保持长时间对实质细胞特异的功能。
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7.发明申请Cultured cell construct which contains spheroids of cultured animal cells and the use thereof 有权含有培养的动物细胞的球体的培养细胞构建体及其用途公开(公告)号：US20090011504A1
公开(公告)日：2009-01-08
申请号：US12230916
申请日：2008-09-08
IPC分类号： C12N5/06
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译： 将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。 因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。 该培养物保持长时间对实质细胞特异的功能。
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8.发明授权Cultured cell construct containing spheroids of cultured animal cells and utilization thereof 有权含培养动物细胞球状体的培养细胞构建体及其应用公开(公告)号：US07470424B2
公开(公告)日：2008-12-30
申请号：US10484839
申请日：2002-07-25
CPC分类号： C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2533/30 , C12N2533/40 , C12N2535/10
摘要： Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.
摘要翻译： 将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。 因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。 该培养物保持长时间对实质细胞特异的功能。
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9.发明授权Brush-like structured surface of poly(ethylene oxide) having elevated density 失效具有高密度的聚（环氧乙烷）的刷状结构化表面公开(公告)号：US07214500B2
公开(公告)日：2007-05-08
申请号：US10507303
申请日：2003-03-07
申请人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Katsumi Uchida , Tadahito Takahashi , Miki Kato
发明人： Kazunori Kataoka , Yukio Nagasaki , Hidenori Otsuka , Katsumi Uchida , Tadahito Takahashi , Miki Kato
IPC分类号： G01N33/53 , C12M1/34 , A61K31/765 , C07K1/10
CPC分类号： G01N33/54393 , C08G65/329 , C08G65/334 , C08G65/336
摘要： A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to sensor surfaces with biosensor surfaces plural times to link the polymers.
摘要翻译： 通过将具有结合位点的主要成分为聚（环氧乙烷）的聚合物的溶液与传感器表面与生物传感器表面多次接触以连接聚合物，提供了显着抑制蛋白质（例如BSA）吸附的表面。
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10.发明申请Brush-like structured surface of poly(ethylene oxide) having elevated density 失效具有高密度的聚（环氧乙烷）的刷状结构化表面公开(公告)号：US20050142028A1
公开(公告)日：2005-06-30
申请号：US10507303
申请日：2003-03-07
IPC分类号： C08G65/329 , C08G65/334 , C08G65/336 , G01N33/543 , G01N21/00
CPC分类号： G01N33/54393 , C08G65/329 , C08G65/334 , C08G65/336
摘要： A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to sensor surfaces with biosensor surfaces plural times to link the polymers.
摘要翻译： 通过将具有结合位点的主要成分为聚（环氧乙烷）的聚合物的溶液与传感器表面与生物传感器表面多次接触以连接聚合物，提供了显着抑制蛋白质（例如BSA）吸附的表面。
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