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    Finely particulate functional metal and finely particulate functional semiconductor each with dispersion stability and process for producing the same
    4.
    发明授权
    Finely particulate functional metal and finely particulate functional semiconductor each with dispersion stability and process for producing the same 失效
    细颗粒功能金属和细颗粒功能半导体均具有分散稳定性及其制备方法

    公开(公告)号：US07122133B2

    公开(公告)日：2006-10-17

    申请号：US10363053

    申请日：2001-02-14

    申请人： Kazunori Kataoka ,  Yukio Nagasaki ,  Hidenori Otsuka ,  Takehiko Ishii

    发明人： Kazunori Kataoka ,  Yukio Nagasaki ,  Hidenori Otsuka ,  Takehiko Ishii

    IPC分类号： C08K3/08 ,  C08K9/04 ,  B01J13/00 ,  B22F9/18 ,  A61K49/04

    CPC分类号： H01B1/22 ,  B22F1/0022 ,  B22F2998/00 ,  B82Y30/00 ,  Y10S977/813 ,  Y10S977/84

    摘要： A stabilized dispersion of metal fine particles comprising, fine particles of metal which is obtained by reducing at least one metallic acid or salt thereof selected from the group consisting of haloauric acid, haloplatinic acid, silver nitrate and halorhodic acid by a reducing agent in the aqueous solution of (1) R-PEG-SX [R is a functional group selected from the group consisting of acetal, aldehyde, hydroxyl group, amino group, carboxyl group, active ester group, azide group, biotin group, monosaccharide, oligosaccharide, amino acid, nucleic acid, allyl group, vinyl benzyl group, methacryloyl group and acryloyl group, PEG is —(CH2CH2O)n—, X is H or pyridylthio group] or (2) R-PEG/PAMA (given structural formula A), and said fine particles load a polymer having PEG unit possessing above mentioned functional group on the surface.

    摘要翻译： 金属微粒的稳定分散体，其包含金属微粒，其是通过还原剂还原至少一种金属酸或其盐，所述金属酸或其盐选自卤代月桂酸，卤铂酸，硝酸银和卤代罗丹酸 （1）R-PEG-SX的溶液[R是选自缩醛，醛，羟基，氨基，羧基，活性酯基，叠氮基，生物素基团，单糖，寡糖，氨基 酸，核酸，烯丙基，乙烯基苄基，甲基丙烯酰基和丙烯酰基，PEG是 - （CH 2 CH 2 CH 2 O） - ，X是H或吡啶硫基]或（2）R-PEG / PAMA（给定结构式A），并且所述细颗粒在表面上加载具有上述官能团的具有PEG单元的聚合物。

    Method of high-speed detection for biological analyte
    5.
    发明申请
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US20070059843A1

    公开(公告)日：2007-03-15

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。

    Method of high-speed detection for biological analyte
    6.
    发明授权
    Method of high-speed detection for biological analyte 失效
    生物分析物高速检测方法

    公开(公告)号：US07732158B2

    公开(公告)日：2010-06-08

    申请号：US10575551

    申请日：2004-09-06

    申请人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    发明人： Yukio Nagasaki ,  Kazunori Kataoka ,  Takehiko Ishii ,  Tadahito Takahashi

    IPC分类号： G01N33/53 ,  G01N33/553 ,  G01N33/544 ,  G01N33/547 ,  G01N33/537

    CPC分类号： G01N33/54393 ,  G01N33/5432

    摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.

    摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。

    Protein charge regulator and protein-encapsulating polymer micelle complex
    7.
    发明授权
    Protein charge regulator and protein-encapsulating polymer micelle complex 有权
    蛋白质电荷调节剂和蛋白质包封的聚合物胶束复合物

    公开(公告)号：US09051354B2

    公开(公告)日：2015-06-09

    申请号：US13256605

    申请日：2009-09-17

    申请人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    发明人： Kazunori Kataoka ,  Nobuhiro Nishiyama ,  Yan Lee ,  Takehiko Ishii

    IPC分类号： A61K47/48 ,  C07K1/113 ,  C07K1/13

    CPC分类号： C07K1/13 ,  A61K47/60 ,  A61K47/645

    摘要： The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.

    摘要翻译： 本发明提供了允许有效地引入细胞（特别是细胞质）中的蛋白质递送装置（例如，聚离子络合物），在血清中是高度稳定的，并且也可广泛应用。 本发明的聚离子络合物包含具有聚阳离子部分和电荷转移蛋白质的阳离子聚合物，其电荷通过特定的电荷调节剂从碱性或中性转变为酸性。