摘要:
It has been found that modification of surfaces of nanoparticles with a RolA protein decreases an immunostimulation activity of the nanoparticles on myeloid dendritic cells and also decreases phagocytosis of the nanoparticles by macrophages. The present invention provides nanoparticles being modified with a biological molecule and having an immune-response evasion function.
摘要:
It has been found that modification of surfaces of nanoparticles with a RolA protein decreases an immunostimulation activity of the nanoparticles on myeloid dendritic cells and also decreases phagocytosis of the nanoparticles by macrophages. The present invention provides nanoparticles being modified with a biological molecule and having an immune-response evasion function.
摘要:
Lysyl oxidase derived from filamentous fungi and a DNA encoding thereof are provided. Lysyl oxidase including a protein described in of the following (a) or (b): (a) a protein having an amino acid sequence set forth in SEQ ID NO: 2; or (b) a protein having an amino acid sequence obtained by modifying a part of the amino acid sequence set forth in SEQ ID NO: 2, and functioning as lysyl oxidase.
摘要翻译:提供衍生自丝状真菌的赖氨酰氧化酶及其编码的DNA。 包含以下(a)或(b)所述的蛋白质的赖氨酰氧化酶:(a)具有SEQ ID NO:2所示的氨基酸序列的蛋白质; 或(b)具有通过修饰SEQ ID NO:2所示氨基酸序列的一部分而作为赖氨酰氧化酶起作用的氨基酸序列的蛋白质。
摘要:
The present invention relates to an Aspergillus sojae leucine aminopeptidase gene or variants thereof, a recombinant DNA including the gene or the variants, and a process for producing leucine aminopeptidase using the recombinant DNA.
摘要:
The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade β-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having β-1,3-glucanase activity (exo-, or endo-β-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having β-1,3-glucanase activity, and a method for the production of said enzymes.
摘要:
A DNA sequence encoding a transport protein responsible for the physical movement of oxalate and formate across the plasma membrane is provided. The protein, OxlT, can be isolated from the gram negative anaerobe, Oxalobacter formigenes. The protein is part of the three protein oxalate/formate antiport exchange system that allows for conversion of extracellular oxalate to formate+CO.sub.2.The OxlT coding sequence can be used to provide a metabolic energy system to the cell. The system comprises the OxlT transport protein in combination with oxalylCoA decarboxylase and formyl-CoA transferase. Expression cassettes can be designed to express all or part of the system in a target host. Such energy generating systems can be used in industrial settings that utilize fermentation. The energy generating systems of the invention extend culture longevity and increase product yield.In another aspect of the invention, the OxlT coding sequence can be used in pharmaceutical compositions for manipulating serum oxalic acid levels in patients in need thereof. In this manner, liposomes comprising the energy generating system can be developed and administered to humans and other animals.
摘要:
It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译:旨在提供曲霉起源磷脂酶A2和编码它的DNA。 即,包含以下蛋白质(a)或(b)的磷脂酶A2:(a)具有SEQ ID NO:1或2所示的氨基酸序列的蛋白质; 和(b)通过部分修饰具有源自SEQ ID NO:1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。
摘要:
It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.
摘要翻译:旨在提供曲霉起源磷脂酶A2和编码它的DNA。 即,包含以下蛋白质(a)或(b)的磷脂酶A2:(a)具有SEQ ID NO:1或2所示的氨基酸序列的蛋白质; 和(b)通过部分修饰具有源自SEQ ID NO:1或2所示的氨基酸序列的氨基酸序列并作为磷脂酶A2的蛋白质。
摘要:
The present invention provides DNA encoding novel pyroglutamyl peptidase derived from Aspergillus oryzae, pyroglutamyl peptidase which is produced by using the DNA, and a method for producing a protein lysate with a good flavor at a high hydrolysis rate.
摘要:
A novel variant belonging to the genus Pediococcus which does not cause fermentation of D-glucose but causes fermentation of pentose, and a process for producing a light-colored soy sauce which comprises adding the variant in the koji preparation step or in the early stage of brewing of soy sauce moromi.