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1.发明授权Interfacial polymerization in a porous substrate and substrates functionalized with photochemical groups 失效在多孔基材中界面聚合和用光化学基团官能化的底物
公开(公告)号：US5627217A
公开(公告)日：1997-05-06
申请号：US536044
申请日：1995-09-29
申请人： Ken Rilling , James Dickson , Ronald Childs , David R. Gagnon
发明人： Ken Rilling , James Dickson , Ronald Childs , David R. Gagnon
CPC分类号： B01D67/0088 , B01D69/141 , B01J31/06 , B01J37/0219 , C08J9/405 , B01J2231/40 , B01J2231/52
摘要： A method of preparing a porous article is provided. The method includes: contacting a porous substrate with a first reactant that enters pores of the substrate; and contacting the porous substrate bearing the first reactant with a second reactant that is capable of reacting with the first reactant in an interfacial polymerization reaction; the amounts of first and second reactant being selected such that there occurs no, or substantially no, closing of pores of the substrate by the formed polymer. The invention also provides a porous article bearing a compound which is photochemically reactive and capable of undergoing a substantially non-reversible chemical transformation upon exposure to ultra-violet, visible or near infra-red irradiation. The photochemically reactive compound can be derivatized by irradiation and further reaction to provide a wide variety of useful membranes, for example, for microfiltration or for biochemical reactions and separations.
摘要翻译： 提供一种制备多孔制品的方法。 该方法包括：使多孔基材与进入基材孔隙的第一反应物接触; 以及使承载所述第一反应物的所述多孔基材与能够在界面聚合反应中与所述第一反应物反应的第二反应物接触; 选择第一和第二反应物的量使得通过所形成的聚合物不发生基本上没有或基本上没有封闭基底的孔。 本发明还提供了一种带有光化学反应性且能够在暴露于紫外线，可见光或接近红外辐射时经历基本不可逆化学转化的化合物的多孔制品。 光化学反应性化合物可以通过辐射和进一步的反应进行衍生化，以提供多种有用的膜，例如微量过滤或生化反应和分离。
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公开(公告)号：US08449463B2
公开(公告)日：2013-05-28
申请号：US13270588
申请日：2011-10-11
申请人： Pierce Nunley , Colin Natali , Faheem Sandhu , Ronald Childs , Brandon Moore
发明人： Pierce Nunley , Colin Natali , Faheem Sandhu , Ronald Childs , Brandon Moore
IPC分类号： A61B1/32
CPC分类号： A61B17/0206 , A61B1/32 , A61B17/025 , A61B17/1671 , A61B17/1757 , A61B17/3468 , A61B17/885 , A61B17/8897 , A61B2017/0256 , A61B2090/062 , A61F2/4465 , A61F2/4611 , A61F2/4684 , A61F2002/2835 , A61F2002/30225 , A61F2002/3023 , A61F2002/30285 , A61F2002/30774 , A61F2002/30825 , A61F2002/30892 , A61F2002/30904 , A61F2002/4475 , A61F2002/4624 , A61F2002/4625 , A61F2002/4629 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029
摘要： A surgical access device including a frame, first and second supports, and first and second retractor blades releasably coupled with the first and second supports, respectively. The frame has first and second arms. The first support is releasably coupled with the first and second arms. The second support is slidably mounted on the first and second arms. The second support is movable between a first position with the retractor blades in close cooperative position and a spaced apart position with respect to the first support. The first and second retractor blades each have a distal end portion configured and adapted to engage a vertebral body. In one method of use, the retractor is inserted through an incision in first orientation with the blades in close approximation and rotated approximately 90°, before spreading the retractor blades to retract tissue.
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公开(公告)号：US09687278B2
公开(公告)日：2017-06-27
申请号：US13424174
申请日：2012-03-19
申请人： Ronald Childs
发明人： Ronald Childs
CPC分类号： A61B17/7064 , A61B17/742 , A61B17/866 , A61B17/8685
摘要： Disclosed is a bone fixation device of the type useful for connecting two or more bones or bone fragments together or connecting soft tissue or tendon to bone. The device comprises an elongate body having a distal anchor thereon. An axially moveable proximal anchor is carried by the proximal end of the fixation device, to accommodate different bone dimensions and permit appropriate tensioning of the fixation device. A sleeve can surround at least a portion of the bone fixation device to promote bone in-growth with or at the bone joint or fracture to facilitate fusion of the bone segment.
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公开(公告)号：US08636655B1
公开(公告)日：2014-01-28
申请号：US13009829
申请日：2011-01-19
申请人： Ronald Childs
发明人： Ronald Childs
IPC分类号： A61B1/32
CPC分类号： A61B17/0206
摘要： Instruments, and methods for performing surgical procedures on the spine, including creating an operative corridor to the spine with a tissue retraction system and registering the tissue retraction system to the patient.
摘要翻译： 用于在脊柱上执行外科手术的仪器和方法，包括用组织缩回系统创建到脊柱的手术走廊，并将组织缩回系统记录到患者身上。
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公开(公告)号：US20120088979A1
公开(公告)日：2012-04-12
申请号：US13270588
申请日：2011-10-11
申请人： Pierce Nunley , Colin Natali , Faheem Sandhu , Ronald Childs , Brandon Moore
发明人： Pierce Nunley , Colin Natali , Faheem Sandhu , Ronald Childs , Brandon Moore
IPC分类号： A61B1/32
CPC分类号： A61B17/0206 , A61B1/32 , A61B17/025 , A61B17/1671 , A61B17/1757 , A61B17/3468 , A61B17/885 , A61B17/8897 , A61B2017/0256 , A61B2090/062 , A61F2/4465 , A61F2/4611 , A61F2/4684 , A61F2002/2835 , A61F2002/30225 , A61F2002/3023 , A61F2002/30285 , A61F2002/30774 , A61F2002/30825 , A61F2002/30892 , A61F2002/30904 , A61F2002/4475 , A61F2002/4624 , A61F2002/4625 , A61F2002/4629 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029
摘要： A surgical access device including a frame, first and second supports, and first and second retractor blades releasably coupled with the first and second supports, respectively. The frame has first and second arms. The first support is releasably coupled with the first and second arms. The second support is slidably mounted on the first and second arms. The second support is movable between a first position with the retractor blades in close cooperative position and a spaced apart position with respect to the first support. The first and second retractor blades each have a distal end portion configured and adapted to engage a vertebral body. In one method of use, the retractor is inserted through an incision in first orientation with the blades in close approximation and rotated approximately 90°, before spreading the retractor blades to retract tissue.
摘要翻译： 一种手术进入装置，包括框架，第一和第二支撑件以及分别与第一和第二支撑件可释放地联接的第一和第二牵开器叶片。 框架具有第一和第二臂。 第一支撑件可释放地与第一和第二臂联接。 第二支撑件可滑动地安装在第一和第二臂上。 第二支撑件可在具有紧密协作位置的牵开器叶片的第一位置和相对于第一支撑件间隔开的位置之间移动。 第一和第二牵开器叶片各自具有构造并适于接合椎体的远端部分。 在一种使用方法中，在扩张牵开器叶片以缩回组织之前，牵开器以第一取向插入叶片近似近似旋转约90°。
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公开(公告)号：US20120245704A1
公开(公告)日：2012-09-27
申请号：US13424174
申请日：2012-03-19
申请人： Ronald Childs
发明人： Ronald Childs
CPC分类号： A61B17/7064 , A61B17/742 , A61B17/866 , A61B17/8685
摘要： Disclosed is a bone fixation device of the type useful for connecting two or more bones or bone fragments together or connecting soft tissue or tendon to bone. The device comprises an elongate body having a distal anchor thereon. An axially moveable proximal anchor is carried by the proximal end of the fixation device, to accommodate different bone dimensions and permit appropriate tensioning of the fixation device. A sleeve can surround at least a portion of the bone fixation device to promote bone in-growth with or at the bone joint or fracture to facilitate fusion of the bone segment.
摘要翻译： 公开了一种用于将两个或多个骨或骨碎片连接在一起或将软组织或腱连接到骨上的骨固定装置。 该装置包括在其上具有远端锚固件的细长主体。 可轴向移动的近端锚固体由固定装置的近端承载，以适应不同的骨尺寸并允许固定装置的适当张紧。 套筒可围绕骨固定装置的至少一部分以促进与骨关节或骨折处的骨生长，以促进骨段的融合。
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公开(公告)号：US20080017578A1
公开(公告)日：2008-01-24
申请号：US11547736
申请日：2005-04-07
申请人： Ronald Childs , Elena Komkova , Lisa Crossley , Alicja Mika
发明人： Ronald Childs , Elena Komkova , Lisa Crossley , Alicja Mika
CPC分类号： B01D69/10 , B01D63/06 , B01D63/061 , B01D63/081 , B01D63/082 , B01D63/10 , B01D67/0006 , B01D67/0079 , B01D67/0088 , B01D2313/14 , B01D2319/025 , B01D2319/06 , B01D2323/30 , B01D2323/40 , B01D2325/02 , B01D2325/28 , B01D2325/36 , B01D2325/38 , B01J20/28033 , B01J20/28035 , B01J20/28047 , B01J20/28052 , B01J20/28085 , B01J20/281 , B01J20/291 , B01L3/50255
摘要： The present application discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers in said membrane stack.
摘要翻译： 本申请公开了一种膜堆叠，其包括第一和第二膜层以及设置在所述第一和第二膜层之间的间隔层，所述膜叠层构造成使得流体在基本上垂直于所述膜层的平面的方向上穿过所述膜堆叠 膜层和所述间隔层。 本申请还公开了一种包括如上所述的膜的模块，所述模块具有基本上垂直于所述膜的主表面的平面和所述膜堆叠中的间隔层的流体流动路径。
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公开(公告)号：US20060121217A1
公开(公告)日：2006-06-08
申请号：US11238642
申请日：2005-09-29
申请人： Ronald Childs , Tapan Dey , Elena Komkova
发明人： Ronald Childs , Tapan Dey , Elena Komkova
CPC分类号： B01D67/0088 , B01D69/04 , B01D69/06 , B01D69/08 , B01D69/12 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/52 , B01D71/60 , B01D2323/02 , B01D2325/36 , B01D2325/38 , Y10T428/13 , Y10T428/1352 , Y10T428/1376 , Y10T428/139 , Y10T428/1393 , Y10T428/24942 , Y10T428/249953 , Y10T428/249958 , Y10T428/24996 , Y10T428/249987 , Y10T428/249991 , Y10T428/249992 , Y10T428/249993 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a composite material comprising a support member that has a plurality of pores extending therethrough, a first polymer which durably coats the pores of the support member, the first polymer layer having both hydrophobic and hydrophilic properties, and a second polymer layer disposed on the surface of the first polymer layer, the second polymer being more hydrophilic than the first polymer layer. The present invention also provides a process for preparing the composite material, and its use as a separation medium.
摘要翻译： 本发明提供了一种复合材料，其包括具有延伸穿过其中的多个孔的支撑构件，第一聚合物，其耐久地涂覆所述支撑构件的孔，所述第一聚合物层具有疏水性和亲水性两者，以及设置第二聚合物层 在第一聚合物层的表面上，第二聚合物比第一聚合物层更亲水。 本发明还提供了一种制备复合材料的方法及其作为分离介质的用途。
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公开(公告)号：US20060000778A1
公开(公告)日：2006-01-05
申请号：US11114872
申请日：2005-04-25
申请人： Ronald Childs , Jie Yu
发明人： Ronald Childs , Jie Yu
IPC分类号： B01D61/00
CPC分类号： B01D61/362 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/10 , B01D69/141 , B01D71/40 , B01D71/44 , B01D71/76 , B01D2323/30 , C08J5/2275 , C08J2323/12 , Y10T428/249953 , Y10T428/249955 , Y10T428/249961
摘要： The present application discloses a composite membrane comprising (a) a support member that has a plurality of pores extending through the support member and (b) a cross-linked copolymer comprising (i) a cationic monomer and an anionic monomer and/or (ii) a zwitterionic monomer, which cross-linked copolymer fills the pores of the support member, the cross-linked copolymer having a permeability for a fluid that is dependent on the polarity of the fluid, wherein the permeability increases with increasing polarity. The present application also discloses a process for the preparation of the composite membrane, a pervaporation apparatus comprising the composite membrane, and methods for the use of the composite material in separation and dehydration processes.
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公开(公告)号：US20050118425A1
公开(公告)日：2005-06-02
申请号：US10513834
申请日：2003-05-07
申请人： Ronald Childs , Feng Shen , Sanju Wang
发明人： Ronald Childs , Feng Shen , Sanju Wang
CPC分类号： A61K9/0024 , A61K9/5026 , A61K9/5036 , A61K9/5073 , A61K9/5089 , Y10T428/2984
摘要： Biomedical materials are encapsulated in ionically crosslinked polymer capsules, preferably alginate microcapsules. The alginate capsules are then subjected, in a liquid vehicle, to an ethylenically unsaturated monomer and an initiator, to induce polymerization of the unsaturated monomer and therey enhance the strength of the capsule wall. The microcapsules can be after-treated with, for example, polysine and alginate to reduce their tendency to elicit an immune response if implanted in an animal. The invention extends to the microcapsules and also to a method of treating or preventing medical conditions in an animal particularly a human, by implanting microcapsule containing biomedical material in the animal.
摘要翻译： 生物医学材料被包封在离子交联的聚合物胶囊中，优选藻酸盐微胶囊。 然后将藻酸盐胶囊在液体载体中进行烯属不饱和单体和引发剂，以诱导不饱和单体的聚合，从而增强胶囊壁的强度。 微胶囊可以用例如聚赖氨酸和藻酸盐进行后处理，以减少它们如果植入动物体内引起免疫应答的倾向。 本发明延伸到微胶囊中，并且还涉及通过将含有生物医学材料的微胶囊植入动物中来治疗或预防动物特别是人类的医学病症的方法。
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