METHOD FOR PRODUCING 1,5-PENTANEDIAMINE
    1.
    发明申请
    METHOD FOR PRODUCING 1,5-PENTANEDIAMINE 审中-公开
    1,5-戊二胺的制备方法

    公开(公告)号:US20130071888A1

    公开(公告)日:2013-03-21

    申请号:US13640793

    申请日:2011-04-11

    IPC分类号: C12N15/52

    摘要: A method of producing 1,5-pentanediamine includes culturing coryneform bacterium having a gene encoding lysine decarboxylase in its chromosome, which coryneform bacterium maintains lysine decarboxylase activity of not less than 50 mU/mg protein during culturing and the gene encoding lysine decarboxylase is linked downstream of a promoter that functions during the logarithmic growth phase.

    摘要翻译: 一种生产1,5-戊二胺的方法包括在其染色体中培养具有编码赖氨酸脱羧酶基因的棒状细菌,棒状细菌在培养期间保持不低于50mU / mg蛋白质的赖氨酸脱羧酶活性,编码赖氨酸脱羧酶的基因连接在下游 在对数生长期间起作用的启动子。

    METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID
    2.
    发明申请
    METHOD FOR PRODUCING LACTIC ACID AND METHOD FOR PRODUCING POLYLACTIC ACID 审中-公开
    生产乳酸的方法和生产聚酸的方法

    公开(公告)号:US20110263811A1

    公开(公告)日:2011-10-27

    申请号:US13142062

    申请日:2009-12-25

    IPC分类号: C08G63/78 C07D319/12 C12P7/56

    摘要: Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.

    摘要翻译: 乳酸通过以下方法获得:(A)连续发酵步骤,其中具有乳酸发酵能力的微生物的发酵培养基通过平均孔径不小于0.01μm的多孔膜过滤 超过1μm,跨膜压力差在0.1〜20kPa的范围内,并收集渗透物,同时将非渗透液体保留在或将非渗透液体返回到培养物中,并向培养物中加入发酵原料 ; (B)通过纳滤膜对步骤(A)中得到的渗透物进行过滤的工序; 和(C)在25℃至200℃下,在不低于1Pa且不大于大气压的压力下,将步骤(B)中得到的渗透物蒸馏的步骤,以回收乳酸。

    Method for producing cadaverine
    5.
    发明授权
    Method for producing cadaverine 有权
    生成尸胺的方法

    公开(公告)号:US08999681B2

    公开(公告)日:2015-04-07

    申请号:US13991929

    申请日:2011-12-08

    IPC分类号: C12P13/00 C12N9/04 C12N9/88

    摘要: A method of producing cadaverine is more efficient and at a higher yield than production methods by the conventional fermentation methods. The method includes culturing coryneform bacterium/bacteria having a resistance to a pH of 5.5 or less. Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity and, preferably, the coryneform bacterium/bacteria has/have homoserine auxotrophy and/or a resistance to S-(2-aminoethyl)-L-cysteine.

    摘要翻译: 与通过常规发酵方法的生产方法相比,生产尸胺的方法更有效并且产量高。 该方法包括培养耐pH为5.5以下的棒状细菌/细菌。 优选地,棒状细菌/细菌具有/具有赖氨酸脱羧酶活性,优选棒状细菌/细菌具有高丝氨酸营养缺陷型和/或对S-(2-氨基乙基)-L-半胱氨酸的抗性。

    METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS
    6.
    发明申请
    METHOD FOR PRODUCING A CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS 审中-公开
    生产化学产品和连续发酵装置的方法

    公开(公告)号:US20110177551A1

    公开(公告)日:2011-07-21

    申请号:US13121727

    申请日:2009-09-16

    IPC分类号: C12P1/00 C12M1/12

    摘要: To control flow velocity of a culture liquid inside a membrane separation tank without giving influences to culture conditions in the fermentation tank, and also suppress precipitation of microorganisms or culture cells so that the production efficiency of the chemical product can be improved, in a method for producing a chemical product including the steps of: cultivating microorganisms or culture cells in a fermentation tank; transferring a culture liquid from the fermentation tank to a membrane separation tank so as to filter the culture liquid through a separation membrane; and collecting a fermentation product from a filtration liquid as the chemical product while refluxing an unfiltered culture liquid that has not been filtered so as to be joined to the culture liquid on an upstream side of the membrane separation tank, one portion of the culture liquid to be transferred from the fermentation tank is allowed to bypass the membrane separation tank depending on a pressure at the culture liquid flow-in side of the membrane separation tank.

    摘要翻译: 为了控制膜分离槽内的培养液的流速,不影响发酵罐中的培养条件,并且还抑制微生物或培养细胞的沉淀,从而可以提高化学品的生产效率 生产化学产品,包括以下步骤:在发酵罐中培养微生物或培养细胞; 将培养液从发酵罐转移到膜分离罐中,以通过分离膜过滤培养液; 并将来自过滤液的发酵产物作为化学产品收集,同时回流未过滤的未过滤的培养液,以便在膜分离罐的上游侧与培养液接合,将一部分培养液转移至 根据膜分离罐的培养液流入侧的压力,从发酵罐转移允许绕过膜分离罐。

    METHOD FOR PRODUCING CADAVERINE
    8.
    发明申请
    METHOD FOR PRODUCING CADAVERINE 有权
    生产CADAVERINE的方法

    公开(公告)号:US20140004576A1

    公开(公告)日:2014-01-02

    申请号:US13991929

    申请日:2011-12-08

    IPC分类号: C12P13/00

    摘要: A method of producing cadaverine is more efficient and at a higher yield than production methods by the conventional fermentation methods. The method includes culturing coryneform bacterium/bacteria having a resistance to a pH of 5.5 or less. Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity and, preferably, the coryneform bacterium/bacteria has/have homoserine auxotrophy and/or a resistance to S-(2-aminoethyl)-L-cysteine.

    摘要翻译: 与通过常规发酵方法的生产方法相比,生产尸胺的方法更有效并且产量高。 该方法包括培养耐pH为5.5以下的棒状细菌/细菌。 优选地,棒状细菌/细菌具有/具有赖氨酸脱羧酶活性,优选棒状细菌/细菌具有高丝氨酸营养缺陷型和/或对S-(2-氨基乙基)-L-半胱氨酸的抗性。

    METHOD FOR PRODUCING CADAVERINE
    9.
    发明申请
    METHOD FOR PRODUCING CADAVERINE 有权
    生产CADAVERINE的方法

    公开(公告)号:US20130323800A1

    公开(公告)日:2013-12-05

    申请号:US13992081

    申请日:2011-12-08

    IPC分类号: C12P13/00

    CPC分类号: C12P13/001 C12Y401/01018

    摘要: A method produces cadaverine more efficiently and at a higher yield than production methods by the conventional fermentation methods. The method includes culturing coryneform bacterium/bacteria having an ability to produce cadaverine and having a resistance to 2,2′-thiobis(ethylamine). Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity and, preferably, the coryneform bacterium/bacteria has/have homoserine auxotrophy and/or a resistance to S-(2-aminoethyl)-L-cysteine.

    摘要翻译: 一种方法通过常规发酵方法比生产方法更有效地产生尸胺,并且产量高。 该方法包括培养具有产生尸胺的能力并具有对2,2'-硫代双(乙胺)的抗性的棒状细菌/细菌。 优选地,棒状细菌/细菌具有/具有赖氨酸脱羧酶活性,优选棒状细菌/细菌具有高丝氨酸营养缺陷型和/或对S-(2-氨基乙基)-L-半胱氨酸的抗性。