公开(公告)号：US5796482A

公开(公告)日：1998-08-18

申请号：US741261

申请日：1996-10-30

申请人： Kexin Xu ,  Michio Naka ,  Norihito Suzuki

发明人： Kexin Xu ,  Michio Naka ,  Norihito Suzuki

IPC分类号： G01N21/21 ,  G01B9/02

CPC分类号： G01N21/21

摘要： The optical measuring apparatus of this invention for measuring a physical amount of a specific component contained in a substance to be measured by the use of measurement light which passes through the substance to be measured and the use of predetermined reference light includes: a first interfering polarizing plate for obtaining a first light interference signal by interfering the measurement light; a second interfering polarizing plate for obtaining a second light interference signal by interfering the reference light; a first photoelectric converting section for converting the first light interference signal into a first electric signal; a second photoelectric converting section for converting the second light interference signal into a second electric signal; a first phase expanding section for expanding a phase of the first electric signal; a second phase expanding section for expanding a phase of the second electric signal; a phase difference measuring section for measuring a phase difference between a phase expanded by the first phase expanding section and a phase expanded by the second phase expanding section; and a physical amount determining section for determining the physical amount of the specific component contained in the substance to be measured depending on the phase difference measured by the phase difference measuring section.

摘要翻译： 本发明的光学测量装置用于通过使用通过待测物质的测量光和使用预定参考光来测量待测物质中所含特定成分的物理量的物理量包括：第一干涉极化 用于通过干涉测量光来获得第一光干涉信号; 第二干涉偏振板，用于通过干涉参考光来获得第二光干涉信号; 第一光电转换部分，用于将第一光干涉信号转换成第一电信号; 第二光电转换部分，用于将第二光干涉信号转换成第二电信号; 第一相位扩展部，用于扩大第一电信号的相位; 第二相位扩展部，用于扩大第二电信号的相位; 相位差测量部分，用于测量由第一相位扩展部分扩展的相位与由第二相位扩展部分扩展的相位之间的相位差; 以及物理量确定部，用于根据由相位差测量部测量的相位差确定待测物质中包含的特定成分的物理量。

公开(公告)号：US6126636A

公开(公告)日：2000-10-03

申请号：US145336

申请日：1998-09-01

申请人： Michio Naka

发明人： Michio Naka

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/107 ,  A61B5/1455 ,  A61M5/00

CPC分类号： A61B5/6842 ,  A61B5/0059 ,  A61B5/1078 ,  A61B5/6833

摘要： A method of and a device for accurately positioning a measuring means such as a measurement probe relative to that target area of a living body which has a unique marking peculiar to the living body. A transparent sheet member is first applied to the target part, and an image of the unique marking is then transferred onto the transparent sheet member. The transparent sheet member bearing the image of the unique marking is associated with the measuring device so that a subsequent measurement can be performed by the measuring device after the image transferred onto the transparent sheet member has been aligned with the unique marking in the target area.

摘要翻译： 一种用于相对于具有生物特有的独特标记的生物体的目标区域精确地定位诸如测量探针的测量装置的方法和装置。 首先将透明片材部件施加到目标部件，然后将唯一标记的图像转印到透明片材部件上。 承载独特标记的图像的透明片材与测量装置相关联，使得在转印到透明片材上的图像已经与目标区域中的唯一标记对准后，可以通过测量装置执行随后的测量。

公开(公告)号：US08436990B2

公开(公告)日：2013-05-07

申请号：US13055240

申请日：2009-07-22

申请人： Daisuke Matsumoto ,  Yasunori Shiraki ,  Michio Naka

发明人： Daisuke Matsumoto ,  Yasunori Shiraki ,  Michio Naka

IPC分类号： G01N21/05

CPC分类号： G01N21/05 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0877 ,  G01N21/0303 ,  G01N27/44791 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2201/0642

摘要： The present invention relates to a microchip 1 having a translucent member 11, a flow channel 10 or a cell formed at a side of the translucent member 11 where light enters, and an aperture 16 formed at a position corresponding to the flow channel 10 or the cell at a side of a translucent member 10 where light goes out. The aperture 16 has a light go-through surface 17 which causes light flux being emitted from the flow channel 10 or the cell to go through and a light reflective surface 18 that totally reflects the incident light flux. A width size W1 of the light go-through surface 17 is smaller than a width size W2 of the flow channel 10 or the cell.

摘要翻译： 本发明涉及一种微芯片1，其具有半透明部件11，流路10或形成在透光部件11的光入射侧的单元，以及形成在对应于流路10或 电池在光出射的半透明构件10的一侧。 孔16具有光通过表面17，其使得从流动通道10或单元发射的光束通过;以及全反射入射光通量的光反射表面18。 光透过表面17的宽度尺寸W1小于流路10或单元的宽度尺寸W2。

公开(公告)号：US5474677A

公开(公告)日：1995-12-12

申请号：US340795

申请日：1994-11-15

申请人： Michio Naka

发明人： Michio Naka

IPC分类号： G01N30/24 ,  G01N33/72 ,  B01D15/08 ,  B01D15/00 ,  G01N30/04

CPC分类号： G01N33/723 ,  G01N30/24

摘要： A number of blood samples collected in sample vessels are allowed to stand by as whole blood or blood cell layer, the sample vessels are sent into sampling part in order, the blood sample suctioned from the sampling nozzle is diluted by mixing with hemolyzing liquid containing labile HbA.sub.1c removing reagent, a part of the mixture is led to a sample-loop of sample injection valve and injected into the column of high pressure liquid chromatograph at a specified time after mixing start, hemoglobin fractions are measured in the state of removal or lowering of labile HbA.sub.1c, and the rate of stable glycohemoglobin is determined from thus obtained chromatogram.

摘要翻译： 将样品容器中收集的多个血液样品作为全血或血细胞层静置，将样品容器依次送入取样部分，从采样喷嘴抽吸的血液样品通过与含有不稳定性的溶血液混合而稀释 HbA1c去除试剂，将一部分混合物引入样品注射阀的样品回路，并在混合开始后的指定时间内注入高压液相色谱柱，在除去或降低的状态下测量血红蛋白级分 由此得到的色谱图确定稳定的糖血红蛋白的比例。

公开(公告)号：US20110134420A1

公开(公告)日：2011-06-09

申请号：US13055240

申请日：2009-07-22

申请人： Daisuke Matsumoto ,  Yasunori Shiraki ,  Michio Naka

发明人： Daisuke Matsumoto ,  Yasunori Shiraki ,  Michio Naka

IPC分类号： G01N21/05

CPC分类号： G01N21/05 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0877 ,  G01N21/0303 ,  G01N27/44791 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2201/0642

摘要： The present invention relates to a microchip 1 having a translucent member 11, a flow channel 10 or a cell formed at a side of the translucent member 11 where light enters, and an aperture 16 formed at a position corresponding to the flow channel 10 or the cell at a side of a translucent member 10 where light goes out. The aperture 16 has a light go-through surface 17 which causes light flux being emitted from the flow channel 10 or the cell to go through and a light reflective surface 18 that totally reflects the incident light flux. A width size W1 of the light go-through surface 17 is smaller than a width size W2 of the flow channel 10 or the cell.

摘要翻译： 本发明涉及一种微芯片1，其具有半透明部件11，流路10或形成在透光部件11的光入射侧的单元，以及形成在对应于流路10或 电池在光出射的半透明构件10的一侧。 孔16具有光通过表面17，其使得从流动通道10或单元发射的光束通过;以及全反射入射光通量的光反射表面18。 光透过表面17的宽度尺寸W1小于流路10或单元的宽度尺寸W2。

公开(公告)号：US06991762B1

公开(公告)日：2006-01-31

申请号：US09655074

申请日：2000-09-05

申请人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

发明人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

IPC分类号： G01N33/48

CPC分类号： G01N1/14 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/084 ,  G01N21/03 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/52 ,  G01N33/521 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346

摘要： A suction generating device for a sample analysis device is provided. The device comprises four parts, namely, a cover plate 61, a middle plate 62, a bottom plate 63 and an operation plate 64. A protruding portion 642 for compressing the suction generating chamber is formed in an approximately center portion on the lower side of the operation plate 64, a protruding portion 641 for operation is formed in an approximately center portion on the upper side of the operation plate 64. A cavity 631 for inserting the sample analysis device therein is formed in an approximately center portion in the bottom plate 63; and a hole 632 for light irradiation is punched in a determined portion in the cavity 631. A concave portion 623 for fitting the operation plate 64 therein is formed in the middle plate 62, and a window section 621 is formed in the center of the concave portion 623 to let the lower protruding portion 642 on the operation plate 64 protrude therethrough. A window section 611 is formed in the cover plate 61 to let the upper protruding portion 641 on the operation plate 64 protrude therethrough.

摘要翻译： 提供了一种用于样本分析装置的抽吸产生装置。 该装置包括四个部分，即盖板61，中间板62，底板63和操作板64。 在操作板64的下侧的大致中央部形成有用于压缩吸引发生室的突出部642，在操作板64的上侧的大致中央部形成有用于操作的突出部641。 用于将样品分析装置插入其中的空腔631形成在底板63中的大致中心部分; 并且在空腔631中的确定部分中冲压用于光照射的孔632。 在中间板62上形成有用于将操作板64嵌合的凹部623，在凹部623的中心形成有窗部621，使操作板64上的下突出部642突出。 在盖板61上形成窗口部611，使操作板64上的上突出部641突出。

公开(公告)号：US06299838B1

公开(公告)日：2001-10-09

申请号：US08726170

申请日：1996-10-04

申请人： Kouji Hirayama ,  Michio Naka

发明人： Kouji Hirayama ,  Michio Naka

IPC分类号： G01N3348

CPC分类号： G01N33/525

摘要： A test apparatus for assaying a component in a liquid sample by measuring a reflected light, comprising a support having a through hole or a light permeable area, a reagent layer having a detecting area fixed on the support to cover said through hole or light permeable area, and a cover which covers at least the detecting area, wherein at least a portion of the cover covering the detecting area is of a color which substantially has no influence on the reflected light at a measured wavelength.

摘要翻译： 一种用于通过测量反射光来测量液体样品中的组分的测试装置，包括具有通孔或透光区域的支撑体，具有固定在支撑体上的检测区域以覆盖所述通孔或透光区域的试剂层 以及覆盖至少所述检测区域的盖，其中覆盖所述检测区域的所述盖的至少一部分具有基本上对所测量的波长的反射光没有影响的颜色。

公开(公告)号：US20060018790A1

公开(公告)日：2006-01-26

申请号：US11234455

申请日：2005-09-23

申请人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

发明人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

IPC分类号： G01N21/00

CPC分类号： G01N1/14 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/084 ,  G01N21/03 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/52 ,  G01N33/521 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346

摘要： This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.

摘要翻译： 本发明提供了一种用于分析能够对少量样品进行快速和精确分析的样品的装置，并且其测量装置中的梯度不受限制。 该装置包括大致矩形的板状主体，​​该主体包括由树脂制成的基部构件和透明覆盖物。 第一凹陷的圆柱形凹部形成在基部构件的上表面中，并且形成有与第一凹陷圆柱形凹部连通的凹槽，凹槽延伸到突出部分5c的端部，并且第二凹陷圆柱形 小于第一凹陷圆柱形凹部的凹部形成在凹槽中的一定位置，凹槽的端部在突出部5c的端部向外侧开口。 然后，将透明覆盖物放置在基底构件的上表面上，然后将其集成在一起。 结果，第一凹陷的圆柱形凹部，凹槽，第二凹陷圆柱形凹部和凹槽的端部处的开口形成为吸入压力产生室，拉伸通道，分析部分和开口 分别绘制样品。

公开(公告)号：US06180062B2

公开(公告)日：2001-01-30

申请号：US09255253

申请日：1999-02-22

申请人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

发明人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masufumi Koike ,  Hisashi Okuda

IPC分类号： G01N3348

CPC分类号： B01L3/50273 ,  B01L3/502 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0481 ,  G01N27/3272 ,  Y10T436/114165 ,  Y10T436/114998

摘要： This invention provides a device for analyzing a sample which is capable of performing rapid and precise analysis of a small amount of sample, and whose gradient in a measuring apparatus is not limited. This device comprises approximately a rectangular plate shaped body comprising a base member made of resin and a transparent covering. A first depressed cylindrical concave portion is formed in the upper surface of the base member, and a groove is formed in communication with the first depressed cylindrical concave portion, the groove extending to the end of the protrusion portion 5c, and a second depressed cylindrical concave portion which is smaller than the first depressed cylindrical concave portion is formed in a certain position in the groove, the end of the groove opening to the outside at the end of the protrusion portion 5c. Then, the transparent covering is placed over the upper surface of the base member and then integrated together. As a result, the first depressed cylindrical concave portion, the groove, the second depressed cylindrical concave portion, and the opening at the end of the groove are formed into a suction pressure generating chamber, a drawing channel, an analytical section, and an opening for drawing a sample, respectively.

摘要翻译： 本发明提供了一种用于分析能够对少量样品进行快速和精确分析的样品的装置，并且其测量装置中的梯度不受限制。 该装置包括大致矩形的板状主体，​​该主体包括由树脂制成的基部构件和透明覆盖物。 第一凹陷的圆柱形凹部形成在基部构件的上表面中，并且形成有与第一凹陷的圆柱形凹部连通的凹槽，延伸到突出部5c的端部的凹槽和第二凹陷的圆柱形凹部 小于第一凹陷圆柱形凹部的部分形成在凹槽中的一定位置，凹槽的端部在突出部5c的端部向外侧开口。 然后，将透明覆盖物放置在基底构件的上表面上，然后将其集成在一起。 结果，第一凹陷的圆柱形凹部，凹槽，第二凹陷圆柱形凹部和凹槽的端部处的开口形成为吸入压力产生室，拉伸通道，分析部分和开口 分别绘制样品。

公开(公告)号：US06325975B1

公开(公告)日：2001-12-04

申请号：US09137169

申请日：1998-08-20

申请人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masafumi Koike ,  Hisashi Okuda

发明人： Michio Naka ,  Kouji Hirayama ,  Yoshihiko Higuchi ,  Masafumi Koike ,  Hisashi Okuda

IPC分类号： G01N2100

摘要： A suction generating device for a sample analysis device is provided. The device comprises four parts, namely, a cover plate 61, a middle plate 62, a bottom plate 63 and an operation plate 64. A protruding portion 642 for compressing the suction generating chamber is formed in an approximately center portion on the lower side of the operation plate 64, a protruding portion 641 for operation is formed in an approximately center portion on the upper side of the operation plate 64. A cavity 631 for inserting the sample analysis device therein is formed in an approximately center portion in the bottom plate 63, and a hole 632 for light irradiation is punched in a determined portion in the cavity 631. A concave portion 623 for fitting the operation plate 64 therein is formed in the middle plate 62, and a window section 621 is formed in the center of the concave portion 623 to let the lower protruding portion 642 on the operation plate 64 protrude therethrough. A window section 611 is formed in the cover plate 61 to let the upper protruding portion 641 on the operation plate 64 protrude therethrough.

摘要翻译： 提供了一种用于样本分析装置的抽吸产生装置。 该装置包括四个部分，即盖板61，中板62，底板63和操作板64.用于压缩抽吸发生室的突出部分642形成在下侧的大致中心部分 操作板64，用于操作的突出部分641形成在操作板64的上侧的大致中心部分。用于将样品分析装置插入其中的空腔631形成在底板63中的大致中心部分 并且在空腔631的确定部分中冲压用于光照射的孔632.在中间板62中形成有用于将操作板64装配在其中的凹部623，并且窗口部621形成在 凹部623使操作板64上的下突出部642突出。 在盖板61上形成窗口部611，使操作板64上的上突出部641突出。