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    CMOS imager with wide dynamic range Pixel
    1.
    发明申请
    CMOS imager with wide dynamic range Pixel 有权
    CMOS成像器具有宽动态范围像素

    公开(公告)号：US20070023786A1

    公开(公告)日：2007-02-01

    申请号：US11311211

    申请日：2005-12-19

    申请人： Kim Johnson ,  Eugene Atlas ,  Sarit Neter

    发明人： Kim Johnson ,  Eugene Atlas ,  Sarit Neter

    IPC分类号： H01L29/768

    CPC分类号： H01L27/14609 ,  H04N5/3559 ,  H04N5/3597 ,  H04N5/37452

    摘要： In one aspect of the present invention, a light sensor is provided in the active pixel sensor cell for sensing incident radiation. The voltage corresponding to the photon-generated or other radiation-generated charge in the active pixel sensor cell is stored on a storage node via a sample-and-hold capacitor. Additional elements, such as source-follower transistors, may reside between the sensing element and the sample-and-hold capacitor. The signal is read via a readout source-follower (RSF) transistor. The readout source-follower drain is connected to the row select switch while its drain is connected to the output node on the column output bus. This configuration couples the storage node to the gate-source capacitance of the readout source-follower transistor. This allows the voltage on the storage node to increase proportionally to the increase in voltage on the readout node when the row select is closed and thus enables the drain current to flow through the RSF to the column output bus.

    摘要翻译： 在本发明的一个方面，光传感器设置在有源像素传感器单元中，用于感测入射辐射。 对应于有源像素传感器单元中的光子产生或其他辐射产生电荷的电压通过采样和保持电容器存储在存储节点上。 诸如源极 - 跟随器晶体管的附加元件可以位于感测元件和采样保持电容器之间。 信号通过读取源极跟随器（RSF）晶体管读取。 读取源极跟随器漏极连接到行选择开关，而其漏极连接到列输出总线上的输出节点。 该配置将存储节点耦合到读出源跟随器晶体管的栅极 - 源极电容。 这允许存储节点上的电压与行选择关闭时读出节点上的电压增加成比例地增加，并且因此使漏极电流能够通过RSF流到列输出总线。

    Process For Forming Pre-Cut Model Specific Gun Wraps
    2.
    发明申请
    Process For Forming Pre-Cut Model Specific Gun Wraps 审中-公开

    公开(公告)号：US20180356176A1

    公开(公告)日：2018-12-13

    申请号：US15619200

    申请日：2017-06-09

    申请人： Ernest James Rose, III ,  Kim Johnson

    发明人： Ernest James Rose, III ,  Kim Johnson

    IPC分类号： F41A35/02 ,  F41H3/02 ,  B44C1/165

    CPC分类号： F41A35/02 ,  B44C1/165 ,  F41H3/02

    摘要： The herein disclosed processes provide a methodology for forming pre-cut gun wraps that may be formed specifically for a particular make and model of firearm or firearm accessory, and may be packaged and shipped to customer in a pre-cut form that allows for easy and adjustable non-permanent application to a firearm or firearm accessory. An exemplary embodiment of the herein disclosed processes includes the steps of: drawings a digital outline of a specific make and model of firearm; measuring a gun wrap surface area; translating the gun wrap surface area into a vector template; combining the vector template with digital artwork to determine a cut path; printing on an adhesive with the digital artwork; laminating the adhesive; cutting the pre-cut model specific gun wrap from the adhesive on a plotter/cutting machine using the cut path; and removing excess material from the pre-cut model specific gun wrap. The adhesive may be a pressure sensitive adhesive vinyl material.

    Methods for operating chemically-sensitive sample and hold sensors
    5.
    发明授权
    Methods for operating chemically-sensitive sample and hold sensors 有权
    操作化学敏感的样品和保持传感器的方法

    公开(公告)号：US08496802B2

    公开(公告)日：2013-07-30

    申请号：US13555998

    申请日：2012-07-23

    申请人： Jonathan Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo

    发明人： Jonathan Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo

    IPC分类号： G01N27/403

    CPC分类号： G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

    摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

    摘要翻译： 与用于分析物测量的非常大规模的FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。 在一个实例中，chemFET阵列基于监测氢离子浓度（pH），其他分析物浓度变化和/或与DNA合成相关的化学过程相关联的结合事件的变化来促进DNA测序技术。

    Integrated sensor arrays for biological and chemical analysis
    7.
    发明授权
    Integrated sensor arrays for biological and chemical analysis 有权
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：US08936763B2

    公开(公告)日：2015-01-20

    申请号：US13125133

    申请日：2009-10-22

    申请人： Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    发明人： Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    IPC分类号： G01N27/403 ,  G01N27/414 ,  C12Q1/68 ,  H01L21/82

    CPC分类号： G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    摘要： The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    摘要翻译： 本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。 在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号 在这样的样品保留区域中。 在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极， 电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。 在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。 本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。

    Chemically-sensitive sample and hold sensors
    9.
    发明授权
    Chemically-sensitive sample and hold sensors 有权
    化学敏感的采样和保持传感器

    公开(公告)号：US08502278B2

    公开(公告)日：2013-08-06

    申请号：US13556001

    申请日：2012-07-23

    申请人： Jonathan Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo

    发明人： Jonathan Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo

    IPC分类号： G01N27/403

    CPC分类号： G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

    摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

    摘要翻译： 与用于分析物测量的非常大规模的FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。 在一个实例中，chemFET阵列基于监测氢离子浓度（pH），其他分析物浓度变化和/或与DNA合成相关的化学过程相关联的结合事件的变化来促进DNA测序技术。

    Exercise Apparatus and Method
    10.
    发明申请
    Exercise Apparatus and Method 有权
    运动器具和方​​法

    公开(公告)号：US20130090218A1

    公开(公告)日：2013-04-11

    申请号：US13267535

    申请日：2011-10-06

    申请人： Kim Johnson

    发明人： Kim Johnson

    IPC分类号： A63B21/02

    CPC分类号： A63B21/0442 ,  A63B21/0552 ,  A63B22/20 ,  A63B2022/0038 ,  A63B2022/0097 ,  A63B2208/0233

    摘要： An exercise apparatus and method allows a user to perform exercises while seated or otherwise supported. Such exercises can assist in avoiding DVT and help those who otherwise might have difficulty exercising due to various conditions. The apparatus requires a base element formed of substantially flat sheet material dimensioned to accommodate a portion of a user's foot, and a leash element attached to a periphery of the base element and dimensioned for retention of the base element. The sheet material reduces friction between a user's foot and the exercise surface to allow a user to exercise their lower extremities via a sliding motion. The leash element allows the base element to be deployed to a floor or other surface for use, and then retrieved without requiring the user to bend over. The leash element is preferably formed of elastic to allow resistive forces to be applied to the base element.

    摘要翻译： 锻炼装置和方法允许使用者在坐着或以其他方式支持时进行锻炼。 这样的练习可以帮助避免DVT，并帮助那些由于各种条件而可能难以行使的人。 该设备需要由基本上平坦的片材形成的基座元件，其尺寸适于容纳使用者的脚的一部分，以及附接到基座元件的周边并且被设计成用于保持基座元件的皮带元件。 片材减少使用者的脚与运动表面之间的摩擦，以允许使用者通过滑动运动锻炼其下肢。 皮带元件允许将基本元件部署到地板或其他表面以供使用，然后检索而不需要用户弯曲。 皮带元件优选地由弹性体形成，以允许将阻力施加到基座元件。