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公开(公告)号:US20080167378A1
公开(公告)日:2008-07-10
申请号:US10580906
申请日:2004-11-26
申请人: Kohji Fukatsu , Ryo Fujii , Makoto Kobayashi , Jinichi Yonemori , Toshio Tanaka
发明人: Kohji Fukatsu , Ryo Fujii , Makoto Kobayashi , Jinichi Yonemori , Toshio Tanaka
IPC分类号: A61K31/192 , C07K14/705 , G01N33/566 , A61P3/04 , A61P3/10 , C07C57/03
CPC分类号: C07D213/643 , A61K31/192 , A61K31/216 , A61K31/341 , A61K31/4453 , A61K31/5375 , C07C45/68 , C07C45/71 , C07C59/68 , C07C69/734 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/64 , C07D277/34 , C07D295/088 , C07D295/096 , C07D307/12 , C07D317/54 , C07D333/32 , C07F7/1804 , C07C49/697 , C07C49/67 , C07C49/84 , C07C49/755 , C07C47/575
摘要: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
摘要翻译: 提供了调节14273受体功能的药剂,其可用作预防或治疗糖尿病,高脂血症等药物。 用于调节14273受体功能的试剂,其包含含有芳环的化合物和能释放阳离子的基团。
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公开(公告)号:US08008525B2
公开(公告)日:2011-08-30
申请号:US10580906
申请日:2004-11-26
申请人: Kohji Fukatsu , Ryo Fujii , Makoto Kobayashi , Jinichi Yonemori , Toshio Tanaka
发明人: Kohji Fukatsu , Ryo Fujii , Makoto Kobayashi , Jinichi Yonemori , Toshio Tanaka
IPC分类号: C07C59/56
CPC分类号: C07D213/643 , A61K31/192 , A61K31/216 , A61K31/341 , A61K31/4453 , A61K31/5375 , C07C45/68 , C07C45/71 , C07C59/68 , C07C69/734 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/64 , C07D277/34 , C07D295/088 , C07D295/096 , C07D307/12 , C07D317/54 , C07D333/32 , C07F7/1804 , C07C49/697 , C07C49/67 , C07C49/84 , C07C49/755 , C07C47/575
摘要: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
摘要翻译: 提供了调节14273受体功能的药剂,其可用作预防或治疗糖尿病,高脂血症等药物。 用于调节14273受体功能的试剂,其包含含有芳环的化合物和能释放阳离子的基团。
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公开(公告)号:US07972800B2
公开(公告)日:2011-07-05
申请号:US12428877
申请日:2009-04-23
申请人: Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人: Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号: G01N33/53 , C07K14/435
CPC分类号: G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译: 通过使用包含与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐 可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。
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公开(公告)号:US20070009513A1
公开(公告)日:2007-01-11
申请号:US10554234
申请日:2004-04-22
申请人: Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
发明人: Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC分类号: A61K39/395 , G01N33/567 , G01N33/53
CPC分类号: G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要: The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
摘要翻译: 使用包含与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽,所述配体肽包含由SEQ ID NO: SEQ ID NO:3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。
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公开(公告)号:US20060216286A1
公开(公告)日:2006-09-28
申请号:US10552014
申请日:2004-04-23
申请人: Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人: Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号: A61K39/395 , G01N33/53
CPC分类号: G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译: 通过使用包含与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和可电离金属元素或其盐 可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。
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公开(公告)号:US07517661B2
公开(公告)日:2009-04-14
申请号:US10554234
申请日:2004-04-22
申请人: Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
发明人: Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC分类号: G01N33/567 , C07K14/705
CPC分类号: G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
摘要: The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
摘要翻译: 使用包含与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽,所述配体肽包含由SEQ ID NO: SEQ ID NO:3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。
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公开(公告)号:US07214495B2
公开(公告)日:2007-05-08
申请号:US10504726
申请日:2003-02-13
申请人: Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人: Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号: G01N33/566
CPC分类号: C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要: By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译: 通过使用(1)具有与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和(2)脂肪酸或类花生酸,化合物 或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。
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公开(公告)号:US20050153289A1
公开(公告)日:2005-07-14
申请号:US10498848
申请日:2002-12-13
申请人: Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
发明人: Shuji Hinuma , Makoto Kobayashi , Toshimitsu Arai , Shoji Fukusumi , Ryo Fujii , Hidetoshi Komatsu , Fumika Matsumura , Yuji Kawamata , Kazuhiro Ogi
IPC分类号: A61K38/17 , A61P35/00 , C07K14/47 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/68 , C07H21/04 , C07K14/42 , C07K16/30 , G01N33/574
CPC分类号: A61K38/1709 , C07K14/4726 , C07K14/705 , C12Q1/6886 , C12Q2600/136 , G01N33/566 , G01N33/689 , G01N2333/705 , G01N2333/726
摘要: The present invention intends to provide a method for analyzing gene expression, a novel use for a receptor protein and the like. Specifically, the present invention provides a method for analyzing gene expression, which is characterized by identifying genes, which are characteristically promoted or suppressed in certain cells or tissues by quantitatively analyzing the individual expressed amounts of a plural number of genes collectively, an assay kit employed in the method and the like. The present invention also provides a method of screening compounds or salts thereof which alter the binding properties of a novel G protein coupled receptor protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 9 or a salt thereof with a ligand, characterized by the use of the protein or salt thereof and a protein (such as a lectin) showing an affinity for a sugar chain which is one of the ligands.
摘要翻译: 本发明意在提供分析基因表达的方法,受体蛋白质的新用途等。 具体地说,本发明提供一种分析基因表达的方法,其特征在于通过定量分析多个基因的个体表达量来统一地鉴定某些细胞或组织中特征性促进或抑制的基因,所用的测定试剂盒 在该方法等中。 本发明还提供一种筛选化合物或其盐的方法,其改变新型G蛋白偶联受体蛋白的结合性质,其包含与SEQ ID NO:9所示的氨基酸序列相同或基本上相同的氨基酸序列或盐 其特征在于使用蛋白质或其盐和显示对作为配体之一的糖链的亲和性的蛋白质(例如凝集素)。
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公开(公告)号:US20050089866A1
公开(公告)日:2005-04-28
申请号:US10504726
申请日:2003-02-13
申请人: Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人: Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号: A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号: C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要: By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译: 通过使用(1)具有与SEQ ID NO:1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和(2)脂肪酸或类花生酸,化合物 或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。
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公开(公告)号:US09455125B2
公开(公告)日:2016-09-27
申请号:US13070115
申请日:2011-03-23
申请人: Akihiro Yoshimura , Tetsuji Sato , Masato Horiguchi , Nobuhiro Wada , Makoto Kobayashi , Hiroshi Tsujimoto , Jun Tamura , Mamoru Naoi
发明人: Akihiro Yoshimura , Tetsuji Sato , Masato Horiguchi , Nobuhiro Wada , Makoto Kobayashi , Hiroshi Tsujimoto , Jun Tamura , Mamoru Naoi
IPC分类号: C23C16/00 , C23F1/00 , H01L21/306 , H01J37/32
CPC分类号: H01J37/32091 , H01J37/32568
摘要: Disclosed is a substrate processing apparatus capable of suppressing generation of plasma in the space between a moving electrode and an end wall at one side of a cylindrical chamber. The substrate processing apparatus includes a cylindrical chamber to receive a wafer, a shower head movable along a central axis of the chamber inside the chamber, a susceptor opposing the shower head in the chamber, and a flexible bellows connecting the shower head to a cover of the chamber, wherein a high frequency power is applied to a processing space presented between the shower head and the susceptor, processing gas is introduced into the processing space, the shower head and the side wall of the chamber are non-contact to each other, and a bypass member is installed electrically connecting the shower head and the cover or the side wall of the chamber.
摘要翻译: 公开了一种能够抑制在圆筒形室的一侧的移动电极与端壁之间的空间中产生等离子体的基板处理装置。 基板处理装置包括用于容纳晶片的圆柱形室,可沿着室内的室的中心轴线移动的喷头,与腔室中的淋浴喷头相对的基座,以及柔性波纹管,其将淋浴头连接到 所述室,其中向所述淋浴喷头和所述基座之间呈现的处理空间施加高频功率,将处理气体引入所述处理空间中,所述淋浴喷头和所述室的侧壁彼此不接触, 并且旁路部件被安装成电连接淋浴头和盖子或室的侧壁。
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