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    Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
    5.
    发明申请
    Engineered microorganisms for increasing product yield in biotransformations, related methods and systems 审中-公开
    用于提高生物转化，相关方法和系统中产品产量的工程微生物

    公开(公告)号：US20080293101A1

    公开(公告)日：2008-11-27

    申请号：US11881748

    申请日：2007-07-27

    申请人： Matthew W. Peters ,  Peter Meinhold ,  Thomas Buelter ,  Marco Landwehr

    发明人： Matthew W. Peters ,  Peter Meinhold ,  Thomas Buelter ,  Marco Landwehr

    IPC分类号： C12P21/04 ,  C12N1/20 ,  C12P7/04 ,  C12M1/00

    CPC分类号： C12N9/0036

    摘要： There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. Other embodiments are also disclosed.

    摘要翻译： 公开了在生物转化中改进产物产率的重组微生物。 在一个实施方案中，将微生物工程化以增加可用于参与生物转化的NAD（P）H需氧化还原酶的NAD（P）H的量。 还公开了使用重组微生物进行工程改造以增加参与生物转化的NAD（P）H需氧化还原酶可用的NAD（P）H量的方法和系统。 还公开了其他实施例。

    ENGINEERED MICROORGANISMS FOR PRODUCING N-BUTANOL AND RELATED METHODS
    6.
    发明申请
    ENGINEERED MICROORGANISMS FOR PRODUCING N-BUTANOL AND RELATED METHODS 审中-公开
    用于生产N-丁醇的工程微生物及相关方法

    公开(公告)号：US20090155869A1

    公开(公告)日：2009-06-18

    申请号：US11949724

    申请日：2007-12-03

    申请人： Thomas Buelter ,  Andrew C. Hawkins ,  Kalib Kersh ,  Peter Meinhold ,  Matthew W. Peters ,  Ezhilkani Subbian

    发明人： Thomas Buelter ,  Andrew C. Hawkins ,  Kalib Kersh ,  Peter Meinhold ,  Matthew W. Peters ,  Ezhilkani Subbian

    IPC分类号： C12P7/16 ,  C12N1/21

    CPC分类号： C12N15/52

    摘要： A recombinant microorganism expressing at least a heterologous enzyme of an NADH-dependent pathway for conversion of a carbon source to n-butanol, metabolic intermediate and/or a derivative thereof and capable of producing n-butanol, a metabolic intermediate and/or a derivative thereof at a high yield and related methods. The recombinant microorganism engineered to inactivate a native enzyme of one or more pathways that compete with NADH-dependent heterologous pathway, and/or to balance the NADH-dependent heterologous pathway with respect to NADH production and consumption.

    摘要翻译： 至少表达NADH依赖性途径的异源酶的重组微生物，用于将碳源转化为正丁醇，代谢中间体和/或其衍生物，并能够生产正丁醇，代谢中间体和/或衍生物 以高产率和相关方法。 重组微生物被工程化以使与NADH依赖性异源途径竞争的一种或多种途径的天然酶失活，和/或平衡NADH依赖性异源途径相对于NADH生产和消耗。