公开(公告)号：US20220091143A1

公开(公告)日：2022-03-24

申请号：US17459090

申请日：2021-08-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Shakila POTHINI ,  Hardeep SANGHA ,  Marc HABERSTROH ,  Puneet SURI ,  Damien LUK

IPC: G01N35/00 ,  G06K19/07 ,  G06K7/10 ,  B01L3/00

Abstract: A system for performing a molecular analysis workflow includes a reaction holder or a reaction substrate, such as a multi-well reaction plate, with a reaction holder/substrate RFID tag, and/or a reagent container with a reagent container RFID tag, and an instrument and/or device that includes an RFID reader/writer operable to read and/or write information to and from the reaction holder/substrate RFID tag and/or the reagent container RFID tag. The reaction holder/substrate RFID tag and the reagent container RFID tag can be utilized separately or together to send and receive and store information, for example, for a workflow of a molecular analysis, such as a polymerase chain reaction (PCR).

公开(公告)号：US20200241023A1

公开(公告)日：2020-07-30

申请号：US16777820

申请日：2020-01-30

Applicant: Life Technologies Holdings PTE Limited ,  Life Technologies Corporation

Inventor： Kuan Moon BOO ,  Wei Fuh TEO ,  Zeqi TAN ,  Soo Yong LAU ,  Ming Tiong SIA ,  Woon Liang SOH ,  Ching Yee LAM ,  Shan Hua DONG ,  Marc HABERSTROH ,  Michael C. PALLAS ,  Hardeep Sangha

IPC: G01N35/00 ,  B01L3/00 ,  B01L7/00 ,  G06K7/10 ,  G06K19/07

Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.

公开(公告)号：US20150191784A1

公开(公告)日：2015-07-09

申请号：US14593749

申请日：2015-01-09

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： David COX ,  Marc HABERSTROH ,  Patrick KINNEY ,  Albert CARRILLO ,  Jon HOSHIZAKI ,  Maryam SHARIATI ,  Howard KING ,  Joe Y. LEE ,  Matthew CHAN

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  B01F13/0059 ,  B01F13/0222 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00466 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/1822 ,  B01L2400/0427 ,  C12Q1/6874 ,  G01N35/00069 ,  G01N35/1002 ,  G01N35/1097 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/1034 ,  G02B21/34 ,  Y10T436/11 ,  Y10T436/143333

Abstract: Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.

Abstract translation: 本文提供了能够快速成像多个波长的样品的测序系统的各种实施例。 在一个实施例中，该系统包括具有多个激发和发射滤波器的快速分度滤光轮，该激发和发射滤光片能够快速旋转进入激发源（例如，弧光灯，激光器） 轮可以被配置成以大约40ms至大约60ms，优选为50ms的范围内的时间量进行索引。该系统还可以被配置为考虑快速启动和停止快速索引所产生的振动 滤光轮以及由其他光源产生的振动。本文还提供了在多个波长下快速成像样品的各种方法。

公开(公告)号：US20190234975A1

公开(公告)日：2019-08-01

申请号：US16262823

申请日：2019-01-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Shakila POTHINI ,  Hardeep SANGHA ,  Marc HABERSTROH ,  Puneet SURI ,  Damien LUK

IPC: G01N35/00 ,  B01L9/00 ,  G06K19/07 ,  G06K7/10

CPC classification number: G01N35/00732 ,  B01L3/5085 ,  B01L3/54 ,  B01L3/545 ,  B01L9/00 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/025 ,  B01L2300/0627 ,  B01L2300/0829 ,  G01N35/00871 ,  G01N2035/00742 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2035/00881 ,  G06K7/10366 ,  G06K19/0723 ,  G16H10/40 ,  G16H40/67 ,  G16H50/20

Abstract: A system for performing a molecular analysis workflow includes a reaction holder or a reaction substrate, such as a multi-well reaction plate, with a reaction holder/substrate RFID tag, and/or a reagent container with a reagent container RFID tag, and an instrument and/or device that includes an RFID reader/writer operable to read and/or write information to and from the reaction holder/substrate RFID tag and/or the reagent container RFID tag. The reaction holder/substrate RFID tag and the reagent container RFID tag can be utilized separately or together to send and receive and store information, for example, for a workflow of a molecular analysis, such as a polymerase chain reaction (PCR).

公开(公告)号：US20190187093A1

公开(公告)日：2019-06-20

申请号：US16330998

申请日：2017-09-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Marc HABERSTROH ,  Geoffrey DAHLHOFF

IPC: G01N27/447 ,  G01R19/25 ,  G01F23/26

CPC classification number: G01N27/44713 ,  G01F23/263 ,  G01N27/44782 ,  G01R19/25

Abstract: The present disclosure relates, in some embodiments, to a system for measuring capillary electrophoresis current. The system includes a plurality of capillaries (206), where each capillary has a cathode end and an anode end. The system further includes a plurality of cathode buffers (202). Each of the cathode buffers is configured to be electrically isolated from the other cathode buffers. Further, each cathode buffer (202) is associated with one capillary (206) of the plurality of capillaries. The cathode end of each capillary (206) is immersed in its associated cathode buffer (202). The system includes a plurality of current sensors (204), each current sensor associated with one capillary of the plurality of capillaries for measuring current. In some embodiments, the plurality of capillaries is four capillaries.