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    Thermal uniformity for thermal cycler instrumentation using dynamic control
    4.
    发明授权
    Thermal uniformity for thermal cycler instrumentation using dynamic control 有权

    公开(公告)号：US10137452B2

    公开(公告)日：2018-11-27

    申请号：US15410708

    申请日：2017-01-19

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Thomas Conner ,  Chee Kiong Lim ,  Michael Pallas ,  Chee Wee Ching

    IPC分类号： B01L7/00 ,  C12M1/40 ,  C12Q3/00

    摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

    Apparatuses, Systems and Methods for Providing Scalable Thermal Cyclers and Isolating Thermoelectric Devices
    5.
    发明申请
    Apparatuses, Systems and Methods for Providing Scalable Thermal Cyclers and Isolating Thermoelectric Devices 审中-公开
    用于提供可扩展热循环器和隔离热电器件的设备，系统和方法

    公开(公告)号：US20150231636A1

    公开(公告)日：2015-08-20

    申请号：US14613496

    申请日：2015-02-04

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Chee Kiong Lim ,  Way Xuang LEE ,  Wuh Ken LOH ,  Chee Wee CHING ,  Chin Yong KOO ,  Siew Ying KOH ,  Tiong Han TOH ,  Kuan Moon BOO ,  Soo Yong LAU

    IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/68

    CPC分类号： B01L7/52 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  C12Q1/6806

    摘要： In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

    摘要翻译： 一方面，公开了一种包括样品块和热电装置的热循环仪系统。 在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。 在各种实施例中，热电装置可操作地耦合到样品块的第二表面。 在各种实施例中，提供了热控制单元。 在各种实施例中，热控制单元包括计算机处理单元。 在各种实施例中，热控制单元包括电流源。 在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。 在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。

    THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL
    10.
    发明申请
    THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开

    公开(公告)号：US20170225169A1

    公开(公告)日：2017-08-10

    申请号：US15410708

    申请日：2017-01-19

    申请人： LIFE TECHNOLOGIES CORPORATION

    发明人： Thomas Conner ,  Chee Kiong Lim ,  Michael Pallas ,  Chee Wee Ching

    IPC分类号： B01L7/00

    CPC分类号： B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1894

    摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.