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    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS
    2.
    发明申请
    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS 审中-公开

    公开(公告)号：US20180282781A1

    公开(公告)日：2018-10-04

    申请号：US15870541

    申请日：2018-01-12

    申请人： Labcyte Inc.

    发明人： Mitchell W. Mutz ,  Richard N. Ellson

    IPC分类号： C12Q1/22

    摘要： The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.

    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE
    3.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE 有权
    用于确定流体样品中分析物浓度的方法和系统

    公开(公告)号：US20160109336A1

    公开(公告)日：2016-04-21

    申请号：US14887320

    申请日：2015-10-19

    申请人： Labcyte Inc.

    发明人： Richard N. Ellson ,  Richard G. Stearns ,  Joseph D. Olechno ,  Ian Sinclair ,  Jonathan Wingfield

    IPC分类号： G01N1/28 ,  H01J49/04

    CPC分类号： G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    摘要： A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

    摘要翻译： 提供了一种用于检测流体样品中分析物浓度的方法和系统。 该方法和系统涉及使用质谱仪或其他离子分析物检测装置对挥发的离子化流体样品进行分析，其提供与所检测的电离分析物的量的强度成比例的信号。 该改进涉及用具有与原始组分相同目的的替代组分替代流体样品中必需的非分析物组分，但是比原始组分和/或分析物更易挥发，或者经历反应以提供较低分子量 重量反应产物，并导致信号和信噪比的强度增加。 声流体喷射是产生流体样品的纳升级大小的液滴的优选方法，然后将其挥发，电离和分析。 还提供了两种离子化合物，其适合作为当电离和加热分解以提供二氧化碳，含氮物质如氨，胺或氮气和挥发性芳族化合物时的替代成分。

    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING
    5.
    发明公开
    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING 审中-公开

    公开(公告)号：US20230249191A1

    公开(公告)日：2023-08-10

    申请号：US18014354

    申请日：2021-08-30

    申请人： Labcyte Inc.

    发明人： Richard N. Ellson

    IPC分类号： B01L7/00 ,  B01L3/00

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2400/0436 ,  B01L2200/16 ,  B01L2300/1805

    摘要： Systems and methods for processing samples in a multi-well reaction vessel can include inserting a multi-well reaction vessel into a heating chamber of a thermal cycler, enclosing the multi-well reaction vessel in the heating chamber, and compressing a bottom surface of the multi-well reaction vessel into a compliant thermally conductive insert to increase a thermal contact area between the bottom surface and the compliant thermally conductive insert. The compliant thermally conductive insert can be placed between the multi-well reaction vessel and a heating element of the thermal cycler, where heat flux from the heating element passes through the compliant thermally conductive insert to the reaction vessel. The compliant thermally conductive insert can include an elastically deformable creped graphite sheet that can reversibly deform according to different compression profiles depending on the topography or flexure of the reaction vessel and/or heating element.

    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION
    7.
    发明申请
    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION 有权

    公开(公告)号：US20210088426A1

    公开(公告)日：2021-03-25

    申请号：US17108931

    申请日：2020-12-01

    申请人： Labcyte Inc.

    发明人： Joseph D. Olechno ,  Richard N. Ellson

    IPC分类号： G01N1/40 ,  B01D21/28 ,  B01L3/02 ,  B01L3/00 ,  C12N15/10 ,  G01N29/02 ,  H01J49/00 ,  H01J49/04

    摘要： A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.

    ROUGHLY CYLINDRICAL SAMPLE CONTAINERS HAVING MULTIPLE RESERVOIRS THEREIN AND BEING ADAPTED FOR ACOUSTIC EJECTIONS
    10.
    发明申请
    ROUGHLY CYLINDRICAL SAMPLE CONTAINERS HAVING MULTIPLE RESERVOIRS THEREIN AND BEING ADAPTED FOR ACOUSTIC EJECTIONS 有权

    公开(公告)号：US20210197192A1

    公开(公告)日：2021-07-01

    申请号：US17200151

    申请日：2021-03-12

    申请人： LABCYTE INC.

    发明人： Richard N. Ellson

    IPC分类号： B01L3/00

    摘要： Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.