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    FOCUSED ACOUSTIC RADIATION FOR RAPID SEQUENTIAL EJECTION OF SUBWAVELENGTH DROPLETS
    1.
    发明公开
    FOCUSED ACOUSTIC RADIATION FOR RAPID SEQUENTIAL EJECTION OF SUBWAVELENGTH DROPLETS 审中-公开

    公开(公告)号：US20240290598A1

    公开(公告)日：2024-08-29

    申请号：US18657016

    申请日：2024-05-07

    申请人： Labcyte Inc.

    发明人： Richard G. Stearns

    IPC分类号： H01J49/04 ,  B01L3/00

    CPC分类号： H01J49/0445 ,  B01L3/502 ,  B01L2200/06 ,  B01L2200/14 ,  B01L2400/0436

    摘要： Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. In one embodiment, a first toneburst is applied to temporarily raise a mound or protuberance on a free surface of the fluid. After the mound has reached a certain state, at least two additional toneburst can be applied to the protuberance to sequentially eject multiple bursts of multiple droplets. In one embodiment, the state of the mound can be maintained by a sustained acoustic signal, during which time multiple additional tonebursts can be applied to sequentially eject multiple bursts of multiple droplets from the mound.

    Focused acoustic radiation for the ejection of sub wavelength droplets
    2.
    发明授权
    Focused acoustic radiation for the ejection of sub wavelength droplets 有权

    公开(公告)号：US11717818B2

    公开(公告)日：2023-08-08

    申请号：US17321201

    申请日：2021-05-14

    申请人： Labcyte Inc.

    发明人： Richard G. Stearns

    IPC分类号： H01J49/04 ,  B01L3/02

    CPC分类号： B01L3/0268 ,  H01J49/0454 ,  B01L2200/0642 ,  B01L2200/141 ,  B01L2400/0436

    摘要： Focused acoustic radiation, referred to as tonebursts, are applied to a volume of liquid to generate a set of droplets. The droplets generated are substantially smaller in scale than the focal spot size of the acoustic beam (e.g., the frequency at which the acoustic transducer operates). Further, the droplets have trajectories that are substantially in the direction of the acoustic beam propagation direction. In one embodiment, a first toneburst is applied to temporarily raise a protuberance on a free surface of the fluid. After the protuberance has reached a certain state, a second toneburst is applied to the protuberance to break it into very small droplets. In one embodiment, the state of the protuberance at which the second toneburst is supplied is the time period shortly after the protuberance reaches its maximum height but before the protuberance recedes back into the volume of fluid.

    ACOUSTIC DROPLET EJECTION OF NON-NEWTONIAN FLUIDS
    4.
    发明申请
    ACOUSTIC DROPLET EJECTION OF NON-NEWTONIAN FLUIDS 有权

    公开(公告)号：US20210394171A1

    公开(公告)日：2021-12-23

    申请号：US17289552

    申请日：2019-10-29

    申请人： Labcyte Inc.

    发明人： Sammy S. Datwani ,  Carson Riche ,  Marsha N. Blauwkamp ,  Justin Blonigan

    IPC分类号： B01L3/02 ,  B05B17/06 ,  B01J19/26 ,  B01J19/00

    摘要： Methods of ejecting droplets containing a non-Newtonian fluid by an acoustic droplet ejector can include applying a tone burst of focused acoustic energy to a fluid reservoir containing a non-Newtonian fluid at sufficient amplitude to effect droplet ejection according to a tone burst pattern. The tone burst pattern may include three discrete tone burst segments, the first tone burst segment having greater duration than the second and third segments, and third segment having greater duration than the second segment. The exact durations and amplitudes of the tone burst segments can be tuned to influence the ejection properties.

    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS
    7.
    发明申请
    ACOUSTIC RADIATION FOR EJECTING AND MONITORING PATHOGENIC FLUIDS 审中-公开

    公开(公告)号：US20180282781A1

    公开(公告)日：2018-10-04

    申请号：US15870541

    申请日：2018-01-12

    申请人： Labcyte Inc.

    发明人： Mitchell W. Mutz ,  Richard N. Ellson

    IPC分类号： C12Q1/22

    摘要： The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.

    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS
    8.
    发明申请
    ACOUSTICALLY EJECTING A DROPLET OF FLUID FROM A RESERVOIR BY AN ACOUSTIC FLUID EJECTION APPARATUS 有权
    通过声音流体喷射装置从储存器呼出流出液体的液滴

    公开(公告)号：US20160243569A1

    公开(公告)日：2016-08-25

    申请号：US14944874

    申请日：2015-11-18

    申请人： LABCYTE INC.

    发明人： Richard G. STEARNS ,  Shehrzad Ahmed QURESHI

    IPC分类号： B05B12/00 ,  B41J2/045

    CPC分类号： B05B12/004 ,  B01J2219/00362 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00677 ,  B01L3/0268 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/0819 ,  B01L2400/0436 ,  B01L2400/0439 ,  B41J2/04541 ,  B41J2/04563 ,  B41J2/04575 ,  B41J2/0458 ,  B41J2/14008

    摘要： The invention provides apparatuses and methods for acoustically ejecting the fluid from a reservoir contained in or disposed on a substrate. The reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to the reservoir. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of the reservoir to an analyzer. The analyzer is capable of determining the energy level of the transmitted acoustic radiation and raising the energy level of subsequent pulses to a level sufficient to eject fluid droplets from the reservoir. The invention is particularly suited for delivering fluid from a plurality of reservoirs in an accurate and efficient manner.

    摘要翻译： 本发明提供了用于从包含在或设置在基板上的储存器中喷射流体的装置和方法。 储存器具有适于容纳流体的部分，并且声辐射发生器被定位成与储存器的声耦合关系。 由声辐射发生器产生的声辐射通过至少一部分储存器传输到分析器。 分析仪能够确定所发射的声辐射的能量水平，并且将后续脉冲的能量水平提高到足以从储存器喷射流体液滴的水平。 本发明特别适用于以准确和有效的方式从多个储层输送流体。

    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE
    9.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE 有权
    用于确定流体样品中分析物浓度的方法和系统

    公开(公告)号：US20160109336A1

    公开(公告)日：2016-04-21

    申请号：US14887320

    申请日：2015-10-19

    申请人： Labcyte Inc.

    发明人： Richard N. Ellson ,  Richard G. Stearns ,  Joseph D. Olechno ,  Ian Sinclair ,  Jonathan Wingfield

    IPC分类号： G01N1/28 ,  H01J49/04

    CPC分类号： G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    摘要： A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

    摘要翻译： 提供了一种用于检测流体样品中分析物浓度的方法和系统。 该方法和系统涉及使用质谱仪或其他离子分析物检测装置对挥发的离子化流体样品进行分析，其提供与所检测的电离分析物的量的强度成比例的信号。 该改进涉及用具有与原始组分相同目的的替代组分替代流体样品中必需的非分析物组分，但是比原始组分和/或分析物更易挥发，或者经历反应以提供较低分子量 重量反应产物，并导致信号和信噪比的强度增加。 声流体喷射是产生流体样品的纳升级大小的液滴的优选方法，然后将其挥发，电离和分析。 还提供了两种离子化合物，其适合作为当电离和加热分解以提供二氧化碳，含氮物质如氨，胺或氮气和挥发性芳族化合物时的替代成分。