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公开(公告)号：US08216512B2
公开(公告)日：2012-07-10
申请号：US10539308
申请日：2003-12-19
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US20060045806A1
公开(公告)日：2006-03-02
申请号：US10539308
申请日：2003-12-19
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
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公开(公告)号：US20130330252A1
公开(公告)日：2013-12-12
申请号：US13964562
申请日：2013-08-12
IPC分类号： G01N1/31
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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4.发明申请Method and apparatus for automated pre-treatment and processing of biological samples 有权用于生物样品自动预处理和处理的方法和装置公开(公告)号：US20060105359A1
公开(公告)日：2006-05-18
申请号：US11156760
申请日：2005-06-20
申请人： John Favuzzi , Kristopher Buchanan , Michael Barber , Loren Bland , Dawn Rohrbacker , Robert Clark , Gordon Feingold , Benno Guggenheimer , Marc Key , Merritt Martin , Robert Lathrop , Jeffery Rau , Jonathan Sweda , Douglas Sweet , John Van Bosch , Lars Winther , Rosanne Welcher
发明人： John Favuzzi , Kristopher Buchanan , Michael Barber , Loren Bland , Dawn Rohrbacker , Robert Clark , Gordon Feingold , Benno Guggenheimer , Marc Key , Merritt Martin , Robert Lathrop , Jeffery Rau , Jonathan Sweda , Douglas Sweet , John Van Bosch , Lars Winther , Rosanne Welcher
CPC分类号： G01N35/0092 , B01L3/508 , B01L7/00 , B01L9/06 , B01L2200/025 , B01L2200/16 , B01L2300/021 , B01L2300/0822 , B01L2300/1822 , G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0095 , G01N35/0099 , G01N35/1002 , G01N35/1004 , G01N35/1011 , G01N2035/00356 , G01N2035/00366 , G01N2035/00445 , G01N2035/00455 , G01N2035/00534 , G01N2035/00633 , G01N2035/00673 , G01N2035/00752 , G01N2035/00861 , G01N2035/00881 , G01N2035/102 , G01N2035/1058 , Y02A90/26 , Y10T436/11 , Y10T436/112499 , Y10T436/12 , Y10T436/2575
摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.
摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。
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公开(公告)号：US08784735B2
公开(公告)日：2014-07-22
申请号：US13964562
申请日：2013-08-12
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US08529836B2
公开(公告)日：2013-09-10
申请号：US13493969
申请日：2012-06-11
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US20120310422A1
公开(公告)日：2012-12-06
申请号：US13493969
申请日：2012-06-11
IPC分类号： G05D7/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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8.发明授权Method and apparatus for automated pre-treatment and processing of biological samples 有权用于生物样品自动预处理和处理的方法和装置公开(公告)号：US07875245B2
公开(公告)日：2011-01-25
申请号：US11156760
申请日：2005-06-20
申请人： John A. Favuzzi , Kristopher S. Buchanan , Michael T. Barber , Loren L. Bland , Dawn M. Rohrbacker , Robert M. Clark , Gordon A. Feingold , Benno M. Guggenheimer , Marc E. Key , Merritt M. Martin, Jr. , Robert L. Lathrop , Jeffery L. Rau , Jonathan R. Sweda , Douglas F. Sweet , John E. Van Bosch , Lars Winther , Rosanne Welcher
发明人： John A. Favuzzi , Kristopher S. Buchanan , Michael T. Barber , Loren L. Bland , Dawn M. Rohrbacker , Robert M. Clark , Gordon A. Feingold , Benno M. Guggenheimer , Marc E. Key , Merritt M. Martin, Jr. , Robert L. Lathrop , Jeffery L. Rau , Jonathan R. Sweda , Douglas F. Sweet , John E. Van Bosch , Lars Winther , Rosanne Welcher
IPC分类号： B01L3/02
CPC分类号： G01N35/0092 , B01L3/508 , B01L7/00 , B01L9/06 , B01L2200/025 , B01L2200/16 , B01L2300/021 , B01L2300/0822 , B01L2300/1822 , G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0095 , G01N35/0099 , G01N35/1002 , G01N35/1004 , G01N35/1011 , G01N2035/00356 , G01N2035/00366 , G01N2035/00445 , G01N2035/00455 , G01N2035/00534 , G01N2035/00633 , G01N2035/00673 , G01N2035/00752 , G01N2035/00861 , G01N2035/00881 , G01N2035/102 , G01N2035/1058 , Y02A90/26 , Y10T436/11 , Y10T436/112499 , Y10T436/12 , Y10T436/2575
摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.
摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。
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公开(公告)号：US20060040341A1
公开(公告)日：2006-02-23
申请号：US11168987
申请日：2005-06-28
申请人： Loren Bland , Marc Key , Lars Winther , David Stanforth , Martin Lindberg
发明人： Loren Bland , Marc Key , Lars Winther , David Stanforth , Martin Lindberg
CPC分类号： G01N1/30 , B01L3/545 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G01N1/312 , G01N35/00732 , G01N2035/00782 , Y10T436/255
摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.
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公开(公告)号：US20080194508A1
公开(公告)日：2008-08-14
申请号：US11884247
申请日：2006-02-06
CPC分类号： G01N15/1459 , G01N33/543 , G01N33/54366 , G01N33/54393 , G01N2015/1486 , Y10T436/101666
摘要： The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing: (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample. Preferably, the matrix retains substantially all the microparticles in or on the container during routine handling, including inversion, of the container, in the absence of mechanical retaining means such as a retainer grid in the container.
摘要翻译： 本发明涉及用于确定样品每单位体积的细胞的绝对计数的组合物和方法。 这种方法包括：（a）提供容器，其包含：（i）预定量的微粒; 和（ii）细胞结合剂; 其中微粒设置在基质中或基体上，该基质附着在容器的至少一个壁上，使得基本上所有的微粒从而附着到容器上; （b）向容器中加入已知体积的样品; （c）通过计数样品体积中的微粒和细胞来确定微粒与细胞的比例; 和（d）通过将每个微粒的细胞数乘以样品中微粒的浓度来确定细胞的绝对计数。 优选地，在没有诸如容器中的保持架网格的机械保持装置的情况下，基体在基本上将容器内的所有微粒保持在容器的常规处理（包括反转）中。
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