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1.发明授权One-piece biocompatible absorbable rivet and pin for use in surgical procedures 失效一体式生物相容性可吸收铆钉和针脚用于外科手术公开(公告)号：US06846313B1
公开(公告)日：2005-01-25
申请号：US09667729
申请日：2000-09-22
申请人： Laurel L. Rogers , Mariann Sayer , David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski , Joseph R. Thomas
发明人： Laurel L. Rogers , Mariann Sayer , David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski , Joseph R. Thomas
CPC分类号： A61B17/68
摘要： A bioabsorbable rivet and pin fastener is formed as an elongated unit that may be used for anchoring, or for attachment of a fixation plate. The rivet has a head mechanically connected to two or more legs that extend generally distally from the head and may flex outwardly from a central rivet axis. The pin is integral with the rivet and oriented along the central axis by a connection such as a web or a plurality of braces, forming an integral, aligned, one-piece assembly that may, for example, be molded as a single piece. The connection breaks under force as the pin is driven into the rivet, so that the pin contacts internal surfaces of the legs and pushes the legs outward into frictional engagement with the surrounding bone. The one-piece assembly may be formed in a gated mold having a central pin with a relief passage that defines the braces between upper and lower portions of the rivet. The braces so formed at the weld line readily part from the mold, and are easily sheared when the pin is advanced during installation of the rivet.
摘要翻译： 生物可吸收的铆钉和销紧固件形成为可用于锚定或用于附接固定板的细长单元。 铆钉具有机械连接到两个或更多个腿的头部，该两个或多个腿部从头部大致向远侧延伸并且可以从中心铆钉轴线向外弯曲。 该销与铆钉成一体并且通过诸如幅材或多个支架的连接件沿着中心轴线定向，形成整体的，对齐的整体式组件，其可以例如被模制成单件。 当销被驱动到铆钉中时，连接断裂，使得销接触腿的内表面并向外推动腿与周围的骨摩擦接合。 一体式组件可以形成在具有中心销的门控模具中，该中心销具有在铆钉的上部和下部之间限定支架的释放通道。 在焊接线处形成的支架容易地与模具成一部分，并且在铆钉安装期间当销前进时容易剪切。
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2.发明授权公开(公告)号：US06241732B1
公开(公告)日：2001-06-05
申请号：US09185051
申请日：1998-11-03
IPC分类号： A61B1756
CPC分类号： A61B17/68
摘要： A bioabsorbable rivet and pin fastening device that may be used for attachment of a fixation plate to bone is described herein. The rivet having a head that is mechanically connected to two or more legs that extend generally distally from the head. The pin being radially compressible and less compliant than the legs of the rivet. The pin when inserted into the rivet will contact the internal surface of said legs to apply force on said legs in a direction perpendicular to the central axis to frictionally engage with the adjacent bone.
摘要翻译： 本文描述了可用于将固定板附接到骨骼上的生物可吸收的铆钉和销固定装置。 该铆钉具有机械连接到两个或更多个腿部的头部，该两个或多个腿部从头部大致向远侧延伸。 该销可径向压缩，并且比铆钉的腿部柔顺。 当插入铆钉中时，销将接触所述腿部的内表面，以在垂直于中心轴线的方向上对所述腿施加力以与邻近的骨摩擦接合。
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公开(公告)号：US5681351A
公开(公告)日：1997-10-28
申请号：US327248
申请日：1994-10-21
CPC分类号： A61B17/0487 , A61B17/0401 , A61B2017/00004 , A61B2017/0445 , A61B2017/0454 , Y10T24/3969 , Y10T24/3996
摘要： The present invention provides a suture clip for attachment to at least one suture comprising a suture clip body having a central longitudinal axis, a proximal end, a distal end, an inner surface, an outer surface and a proximal surface, wherein the inner surface forms a passage that is substantially parallel to the longitudinal axis and is connected to the outer surface by a longitudinal slot which extends from the distal end to the proximal end of the suture clip body and the proximal surface has a major dimension at least five times larger than the diameter of said suture and a collar disposed about said suture clip body engaging the outer surface of the suture clip body to deflect the inner surface to frictionally engage the suture. Also described herein are methods of using this suture clip in surgical procedures.
摘要翻译： 本发明提供一种用于连接至至少一条缝合线的缝线夹，其包括具有中心纵向轴线，近端，远端，内表面，外表面和近端表面的缝合夹主体，其中内表面形成 通道，其基本上平行于纵向轴线并且通过纵向槽连接到外表面，所述纵向狭槽从缝合夹主体的远端延伸到近端，并且近端表面的主要尺寸至少大于 所述缝合线的直径和围绕所述缝合夹主体设置的衣领与缝合夹主体的外表面接合以使内表面偏转以摩擦地接合缝合线。 本文还描述了在外科手术中使用该缝合夹的方法。
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4.发明授权High strength, fast absorbing, melt processable, gycolide-rich, poly(glycolide-co-p-dioxanone) copolymers 失效高强度，快速吸收，可熔融加工，富含甘油醚的聚（乙交酯 - 共对二恶烷酮）共聚物
公开(公告)号：US5633343A
公开(公告)日：1997-05-27
申请号：US497127
申请日：1995-06-30
IPC分类号： A61L17/00 , A61L15/26 , A61L17/12 , A61L27/00 , A61L31/06 , C08G63/06 , C08G63/08 , C08G63/66 , C08G63/664 , C08G63/78 , C08G63/82 , C08L101/16
CPC分类号： C08G63/823 , A61L15/26 , A61L17/12 , A61L31/06 , C08G63/664
摘要： Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and stiffness, and fast absorption rates and breaking strength retention (BSR) profiles, useful in a variety of medical devices. Most importantly, for suture applications where Vicryl.RTM.-like polyglcolide-polylactide sutures with excellent tensile properties, but shorter BSR profiles than Vicryl.RTM. are needed. The copolymers of the present invention have such properties, making them useful in plastic surgery where faster absorption times would lead to less tissue scarring.
摘要翻译： 描述了基于内酯单体乙交酯和对二恶烷酮的脂族聚酯的可吸收，分段的共聚物。 分段共聚物表现出广泛的性能，特别是高强度和刚度，以及快速吸收速率和断裂强度保持（BSR）轮廓，可用于各种医疗设备。 最重要的是，对于具有优异拉伸性能的Vicryl TM样聚丙交酯 - 聚丙交酯缝线的缝合应用，需要比Vicryl TM更短的BSR曲线。 本发明的共聚物具有这样的性质，使得它们可用于整形手术，其中更快的吸收时间将导致较少的组织瘢痕形成。
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公开(公告)号：US5264540A
公开(公告)日：1993-11-23
申请号：US916919
申请日：1992-07-20
IPC分类号： A61L17/10 , A61L27/18 , A61L29/06 , A61L31/06 , C08G67/04 , C08G63/00 , C08G63/02 , C08G67/00 , C08G69/00
摘要： An improved process for preparing an aromatic polyanhydride is disclosed. The aromatic polyanhydride is prepared by reacting an aromatic dicarboxylic acid with an anhydride to form an anhydride prepolymer, isolating and purifying the prepolymer, and subjecting the prepolymer to melt polycondensation conditions. The improvement specifically relates to the purification of the acid so it is essentially free of impurities before it is reacted with the anhydride.The polymers prepared from the improved process have higher molecular weights than the molecular weights achieved from the prior art processes, and exhibit outstanding thermal stability and mechanical properties. This combination of properties allows the aromatic polyanhydrides to be melt processed to prepare numerous devices. In addition, these aromatic polyanhydrides are bioabsorbable, and this attribute in combination with its ability for melt processing makes the polyanhydrides particularly well-suited for the preparation of implantable surgical devices such as wound closure devices which are designed to absorb in the body when exposed to moist bodily tissue.
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6.发明申请Segmented, Semicrystalline Poly(Lactide-co-epsilon-Caprolactone) Absorbable Copolymers 审中-公开分段，半结晶聚（丙交酯 - 共 - 己内酯）可吸收共聚物公开(公告)号：US20130236499A1
公开(公告)日：2013-09-12
申请号：US13417810
申请日：2012-03-12
CPC分类号： C08G63/08 , A61L17/12 , A61L27/18 , A61L27/58 , C08G63/912
摘要： Novel semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. The novel polymer compositions are useful for long term absorbable meshes, surgical sutures, especially monofilament sutures, and other medical devices.
摘要翻译： 公开了具有长期吸收特性的丙交酯和ε-己内酯的新型半结晶分段共聚物。 新型聚合物组合物可用于长期可吸收网眼，手术缝合线，特别是单丝缝合线和其它医疗装置。
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7.发明申请公开(公告)号：US20120323273A1
公开(公告)日：2012-12-20
申请号：US13330741
申请日：2011-12-20
IPC分类号： A61L17/10
CPC分类号： A61L17/10 , A61B17/0401 , A61B17/06066 , A61B17/06166 , A61B2017/00004 , A61B2017/00893 , A61B2017/0414 , A61B2017/0458 , A61B2017/06171 , A61L17/005 , A61L17/04 , A61L17/06 , A61L17/105 , A61L17/145 , A61L2300/402 , A61L2300/406 , A61L2300/41 , D04C1/12 , D10B2509/04
摘要： A novel high tensile strength semi-absorbable composite suture with minimized non-absorbable mass. The suture has a core made from a bioabsorbable polymer. The core is covered by a braided sheath. The braided sheath is made from an absorbable yarn and a bioabsorbable yarn. The bioabsorbable yarn is made from a least one filament of a bioabsorbable polymer. The nonabsorbable yarn is made from at least one filament of ultra high molecular weight polyethylene.
摘要翻译： 一种具有最小不吸收质量的新型高抗拉强度半吸收复合缝合线。 缝线具有由生物可吸收聚合物制成的芯。 芯由编织护套覆盖。 编织护套由可吸收纱线和生物可吸收纱线制成。 生物可吸收纱线由生物可吸收聚合物的至少一根丝制成。 非吸收性纱线由至少一根超高分子量聚乙烯丝制成。
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8.发明授权Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof 有权生物可吸收多孔增强组织植入物及其植入物的制备方法公开(公告)号：US07368124B2
公开(公告)日：2008-05-06
申请号：US10383369
申请日：2003-03-07
申请人： Iksoo Chun , Dennis D. Jamiolkowski , Kelly R. Brown , Julia Hwang , Francois Binette , Mora Carolynne Melican
发明人： Iksoo Chun , Dennis D. Jamiolkowski , Kelly R. Brown , Julia Hwang , Francois Binette , Mora Carolynne Melican
IPC分类号： A61F13/00
CPC分类号： A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant is disclosed. The tissue implant may be bioabsorbable, and is made from a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a common solvent.
摘要翻译： 公开了生物相容性组织植入物。 组织植入物可以是生物可吸收的，并且由生物相容的聚合物泡沫制成。 组织植入物还包括生物相容性加强构件。 聚合物泡沫和增强构件可溶于常用溶剂。
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公开(公告)号：US07169187B2
公开(公告)日：2007-01-30
申请号：US10602338
申请日：2003-06-24
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： The present invention is directed to stents that are formed into a helical structure having a plurality of coils, a longitudinal axis, an internal longitudinal passage, a distal section and a proximal section having different diameters; where the structure is made from a fiber having a cross-section and including an inner core having an exterior surface made from a biodegradable polymer having a first degradation rate and an outer section made from a blend of a first biodegradable polymer component and a second biodegradable polymer component covering the exterior surface of the inner core and having a second degradation rate; where the second degradation rate is lower than the first degradation rate.
摘要翻译： 本发明涉及形成具有多个线圈，纵向轴线，内部纵向通道，远端部分和具有不同直径的近端部分的螺旋结构的支架; 其中结构由具有横截面的纤维制成，并且包括具有由具有第一降解速率的生物可降解聚合物制成的外表面的内芯和由第一可生物降解的聚合物组分和第二可生物降解的共混物制成的外部部分 聚合物组分覆盖内芯的外表面并具有第二降解速率; 其中第二降解速率低于第一降解速率。
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公开(公告)号：US07163562B2
公开(公告)日：2007-01-16
申请号：US10059637
申请日：2002-01-29
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a pre-determined period of time through normal flow of body fluids passing through the lumen.
摘要翻译： 用于植入人体内腔的可生物降解支架。 一个实施方案中的支架由具有内芯和外层的生物可降解纤维制成。 外层是两种聚合物组分的混合物。 内核具有第一降解率，外层具有第二降解率。 第二降解速率比第一降解速率慢。 纤维在体内软化，使得支架在通过通过管腔的体液的正常流动在预定时间段之后容易地作为软化碎片或细丝从内腔通过。
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