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11 条记录 (耗时 0.044 秒)

    Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
    7.
    发明申请
    Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents 审中-公开
    识别靶向trna剪接内切核酸酶的化合物的方法和所述化合物作为抗增殖剂的用途

    公开(公告)号：US20070020630A1

    公开(公告)日：2007-01-25

    申请号：US10551301

    申请日：2004-03-26

    申请人： Christopher Trotta

    发明人： Christopher Trotta

    IPC分类号： C40B30/06 ,  C40B40/08 ,  A61K48/00

    CPC分类号： C12N9/22 ,  C12Q1/6897 ,  C12Q2539/105

    摘要： The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.

    摘要翻译： 本发明涉及筛选和鉴定调节活性tRNA剪接核酸内切酶的化合物的方法。 特别地，本发明提供了用于鉴定抑制动物TRNA剪接内切核酸酶的化合物的测定。 本发明的方法提供了用于鉴定可用于治疗和/或预防癌症的药物引用的化合物文库的高通量筛选的简单，灵敏的测定。

    RNA processing protein complexes and uses thereof
    9.
    发明申请
    RNA processing protein complexes and uses thereof 审中-公开
    RNA加工蛋白复合物及其用途

    公开(公告)号：US20050053985A1

    公开(公告)日：2005-03-10

    申请号：US10884695

    申请日：2004-07-02

    申请人： Christopher Trotta ,  Sergey Paushkin

    发明人： Christopher Trotta ,  Sergey Paushkin

    IPC分类号： C07K14/47 ,  C12N20060101 ,  C12N9/22 ,  C12P19/34 ,  C12Q1/68

    CPC分类号： C12Q1/6897 ,  C07K14/47 ,  C12N9/22

    摘要： The invention provides human protein complexes with endonuclease activity. In particular, the invention provides human protein complexes with tRNA splicing endonuclease activity and/or 3′ end pre-mRNA endonuclease activity. The invention also provides a splice variant of human Sen2, namely human Sen2deltaEx8, and human protein complexes comprising human Sen2deltaEx8. The human Sen2deltaEx8 complexes have pre-tRNA cleavage activity and/or 3′ end pre-mRNA endonuclease activity. The invention also provides human protein complexes with pre-ribosomal RNA cleavage activity. The invention also provides antibodies that immunospecifically bind to a complex described herein or a component thereof, and methods of diagnosing, preventing, treating, managing or ameliorating a disorder utilizing such antibodies. The present invention also provides methods utilizing the complexes described herein, inter alia, in screening, diagnosis, and therapy. The invention further provides methods of preparing and purifying the complexes. The present invention further provides methods of identifying a compound that modulates the expression of a component of a complex described herein, the formation of a complex described herein or the activity of a complex described herein, and methods of preventing, treating, managing or ameliorating a disorder, such as a proliferative disorder, or a symptom thereof utilizing a compound identified in accordance with the methods.

    摘要翻译： 本发明提供具有内切核酸酶活性的人蛋白复合物。 特别地，本发明提供具有tRNA剪接核酸内切酶活性和/或3'末端pre-mRNA内切酶活性的人蛋白复合物。 本发明还提供人Sen2的剪接变体，即人Sen2deltaEx8，以及包含人Sen2deltaEx8的人蛋白复合物。 人类Sen2deltaEx8复合物具有pre-tRNA切割活性和/或3'末端pre-mRNA内切核酸酶活性。 本发明还提供具有前核糖体RNA切割活性的人蛋白复合物。 本发明还提供了免疫特异性结合本文所述的复合物或其组分的抗体，以及利用此类抗体诊断，预防，治疗，治疗或改善病症的方法。 本发明还提供了利用本文所述的复合物，特别是在筛选，诊断和治疗中的方法。 本发明还提供了制备和纯化复合物的方法。 本发明还提供了鉴定调节本文所述复合物组分的表达，本文所述的复合物的形成或本文所述的复合物的活性的化合物的方法，以及预防，治疗，治疗或改善 疾病，例如增殖性疾病，或其症状，利用根据该方法鉴定的化合物。

    Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules
    10.
    发明申请
    Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules 审中-公开
    用于鉴定抗真菌和/或抗增殖分子的trna剪接途径的靶向酶

    公开(公告)号：US20070178456A1

    公开(公告)日：2007-08-02

    申请号：US10551300

    申请日：2004-03-26

    申请人： Christopher Trotta

    发明人： Christopher Trotta

    IPC分类号： C40B30/06 ,  C40B40/04 ,  C40B50/06

    CPC分类号： C12Q1/6897 ,  C12N15/1034 ,  C12Q1/18 ,  G01N33/5011 ,  G01N2333/9015 ,  C12Q2539/105

    摘要： The present invention relates to a method for screening and identifying compounds that modulate the activity of one or more components in the tRNA splicing pathway. In particular the invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease and/or tRNA splicing ligase. The invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease and/or animalia tRNA splicing ligase. The invention also provides assays for the identification of compounds that inhibit fungal tRNA splicing endonuclease and/or fungal tRNA splicing ligase. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer and/or fungal infections.

    摘要翻译： 本发明涉及筛选和鉴定调节tRNA剪接途径中一种或多种组分的活性的化合物的方法。 特别地，本发明涉及筛选和鉴定调节活性tRNA剪接内切核酸酶和/或tRNA剪接连接酶的化合物的方法。 本发明提供了用于鉴定抑制动物TRNA剪接内切核酸酶和/或动物TRNA剪接连接酶的化合物的测定。 本发明还提供了用于鉴定抑制真菌tRNA剪接内切核酸酶和/或真菌tRNA剪接连接酶的化合物的测定法。 本发明的方法提供了一种用于高通量筛选化合物文库以鉴定可用于治疗和/或预防癌症和/或真菌感染的药物引线的简单敏感的测定法。