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公开(公告)号：US20210123009A1
公开(公告)日：2021-04-29
申请号：US17079100
申请日：2020-10-23
Inventor： Steven Huei YEO , Siu Wee HON , Han WEI , Yvonne PECK , Way Xuang LEE , Benyong SHI , Chee Wai CHAN , Beng Heng (Derrick) LIM , Dhanaraj SHANMUGAM , Stacey TEO , Jun Yan THAM , Kok Shyong CHONG , Li Yang LIM , Michael GORDON , Nektaria ANDRONIKOU , Chris ROSSMANN , Xavier DE Mollerat DU JEU , Ulrich FORKE
Abstract: The present disclosure provides electroporation cartridges for single use electroporation as well as electroporation cartridges for automated batch processing, electroporation instruments and systems and methods of electroporation using these devices and systems. In some embodiments, electroporation cartridges comprise an electroporation chamber defined by an elongate body, a first electrode at a proximal end and a second electrode at a distal end of a chamber. Electroporation systems of the disclosure include one or more components including a pulse generator, compartments for placing either flow-through or single use electroporation cartridges, components for storage of cells, cooling and pre-cooling mechanisms, removably insertable modular casings having compartments for holding and arranging electroporation system and reagent components, one or more pumps for moving sample through the system, and processors and controllers.
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公开(公告)号：US20190126281A1
公开(公告)日：2019-05-02
申请号：US16116801
申请日：2018-08-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Yong CHU , Jeffrey MARKS , Jacob FREUDENTHAL , Mingsong CHEN , Tiong Han TOH , Mauro AGUANNO , Lik Seng LAU , Lian Seng LOH , Kok Siong TEO , Zeng Wei CHU , Xin MATHERS , Michael UY , Huei Steven YEO , Kuan Moon BOO , Way Xuang LEE , Chin Yong KOO , Wei Fuh TEO , Soo Yong LAU , Hon Siu SHIN , Zeqi TAN , Thomas WESSEL , David WOO
IPC: B01L7/00 , G01N21/27 , G01N21/64 , C12Q1/6806 , G01N35/02
Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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Patent Agency Ranking
公开(公告)号：US20180056296A1
公开(公告)日：2018-03-01
申请号：US15640241
申请日：2017-06-30
Applicant: Life Technologies Corporation
Inventor： Hon Siu SHIN , Chin Yong KOO , Way Xuang LEE , Chee Kiong LIM , Chee Wee CHING , Niroshan RAMACHANDRAN
IPC: B01L7/00
CPC classification number: B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/12 , B01L2300/1822
Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
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4.发明申请Apparatuses, Systems and Methods for Providing Thermocycler Thermal Uniformity 审中-公开提供热循环器热均匀性的设备，系统和方法公开(公告)号：US20160214110A1
公开(公告)日：2016-07-28
申请号：US14917400
申请日：2014-09-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Hon Siu SHIN , Chin Yong KOO , Way Xuang LEE , Chee Kiong LIM , Chee Wee CHING , Niroshan RAMACHANDRAN
IPC: B01L7/00
CPC classification number: B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/12 , B01L2300/1822
Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.
Abstract translation: 公开了一种包括样品块和两个或更多个热电装置的热块组件。 样品块具有构造成容纳多个反应容器和相对的底表面的顶表面。 热电装置可操作地耦合到样品块，其中每个热电装置包括用于热传感器的壳体和具有控制器的热控制界面。 每个热电装置进一步构造成彼此独立地操作以在整个样品块中提供基本均匀的温度分布。
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公开(公告)号：US20240416335A1
公开(公告)日：2024-12-19
申请号：US18739087
申请日：2024-06-10
Inventor： Wui Khen Kevin LIAW , Kuan Moon Boo , Huei Steven YEO , Wern Yuh FOO , Joshua Mathew MEAD , Justina Linkai BONG , Mikko MAKINEN , Mio Xiu Lu LING , Way Xuang LEE , Wen Lun CHAN , Yunxiang LIU
IPC: B01L3/02
Abstract: Multichannel pipettes, electroporation systems utilizing the multichannel pipettes and methods for electroporating a cell. The electroporation system includes a multichannel pipette, a pipette tip(s), a pipette docking assembly, and a pulse generator. The pipette docking assembly includes a pipette station, a pipette station guard, and a reservoir.
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公开(公告)号：US20240150699A1
公开(公告)日：2024-05-09
申请号：US18468504
申请日：2023-09-15
Inventor： Han WEI , Chee Wai CHAN , Wui Khen LIAW , Shan Hua DONG , See Chen GOH , Huei Steven YEO , Harmon Cosme SICAT, JR. , Mio Xiu Lu LING , Josh M. MEAD , Mikko MAKINEN , Beng Heng LIM , Kuan Moon BOO , Justina Linkai BONG , Chye Sin NG , Wee Liam LIM , Li Yang LIM , Way Xuang LEE
CPC classification number: C12M35/02 , B01L3/0217 , B01L3/0275 , B01L2200/025 , B01L2200/0647 , B01L2300/0645 , B01L2300/12
Abstract: An electroporation system including one or more of a pipette, a pipette tip, a pipette docking assembly, and a pulse generator. The pipette docking assembly includes a pipette station, a pipette station guard, and a reservoir (e.g., a buffer tube). A method for transfecting a cell with a payload including providing an electroporation system, providing the cell, providing the payload, introducing the cell and the payload into a pipette tip, and electroporating the cell within the pipette tip by operating the electroporation system.
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7.发明申请Apparatuses, Systems and Methods for Providing Scalable Thermal Cyclers and Isolating Thermoelectric Devices 审中-公开用于提供可扩展热循环器和隔离热电器件的设备，系统和方法公开(公告)号：US20150231636A1
公开(公告)日：2015-08-20
申请号：US14613496
申请日：2015-02-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Chee Kiong Lim , Way Xuang LEE , Wuh Ken LOH , Chee Wee CHING , Chin Yong KOO , Siew Ying KOH , Tiong Han TOH , Kuan Moon BOO , Soo Yong LAU
CPC classification number: B01L7/52 , B01L2200/147 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1883 , C12Q1/6806
Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
Abstract translation: 一方面，公开了一种包括样品块和热电装置的热循环仪系统。 在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。 在各种实施例中，热电装置可操作地耦合到样品块的第二表面。 在各种实施例中，提供了热控制单元。 在各种实施例中，热控制单元包括计算机处理单元。 在各种实施例中，热控制单元包括电流源。 在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。 在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。
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