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    Medical devices having nanoporous coatings for controlled therapeutic agent delivery
    5.
    发明授权
    Medical devices having nanoporous coatings for controlled therapeutic agent delivery 有权
    具有用于受控治疗剂递送的纳米多孔涂层的医疗装置

    公开(公告)号：US08187255B2

    公开(公告)日：2012-05-29

    申请号：US11701768

    申请日：2007-02-02

    申请人： Jan Weber ,  Liliana Atanasoska

    发明人： Jan Weber ,  Liliana Atanasoska

    IPC分类号： A61K9/22 ,  A61F2/06 ,  G01N21/75 ,  G01N31/22 ,  G01N33/52

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/10 ,  A61L29/146 ,  A61L29/16 ,  A61L31/082 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/608 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/375

    摘要： According to an aspect of the invention, medical devices are provided which include a substrate, at least one porous reservoir containing at least one therapeutic agent disposed over the substrate, at least one nanoporous layer disposed over the at least one porous reservoir, and at least one plugged aperture, which may be located within the substrate, within the nanoporous layer, or both. According to another aspect of the invention, a method of forming a medical device is provided which includes (a) forming a porous reservoir over a substrate, (b) forming a nanoporous layer over the porous reservoir, (c) forming an aperture within the substrate or the nanoporous layer, (d) filling the porous reservoir with therapeutic agent through the aperture, and (d) plugging the aperture.

    摘要翻译： 根据本发明的一个方面，提供了医疗装置，其包括基底，至少一个多孔储存器，其包含设置在基底上的至少一种治疗剂，至少一个纳米多孔层，设置在所述至少一个多孔容器上， 可以位于衬底内的一个堵塞的孔，在纳米多孔层内，或两者。 根据本发明的另一方面，提供了一种形成医疗装置的方法，其包括（a）在衬底上形成多孔容器，（b）在所述多孔容器上形成纳米多孔层，（c）在所述多孔容器内形成孔， 底物或纳米多孔层，（d）通过孔填充具有治疗剂的多孔容器，和（d）堵塞孔。

    INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER
    7.
    发明申请
    INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER 有权
    用于与电力来源连接的治疗药物的内部医疗装置

    公开(公告)号：US20110046539A1

    公开(公告)日：2011-02-24

    申请号：US12939363

    申请日：2010-11-04

    申请人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas J. Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    摘要翻译： 本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。 此外，治疗剂源适于将治疗剂引入电场。 另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
    8.
    发明申请
    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 失效
    用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置

    公开(公告)号：US20090326638A1

    公开(公告)日：2009-12-31

    申请号：US12489948

    申请日：2009-06-23

    申请人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    发明人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    IPC分类号： A61F2/06

    CPC分类号： A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.

    摘要翻译： 根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域， 第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。