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1.发明授权Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen 失效用8-甲氧基补骨脂素灭活血液制剂中细菌的方法
公开(公告)号：US5288605A
公开(公告)日：1994-02-22
申请号：US844790
申请日：1992-03-02
IPC分类号： A61J3/00 , A01N1/02 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , A61M1/36 , A61M37/00 , A61N1/30
CPC分类号： A61K31/37 , A01N1/0215 , A01N1/0242 , A01N1/0294 , A61K41/0019 , A61L2/0011 , A61M1/3616 , A61M1/3683 , A61M1/3686
摘要： Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated using 8-methoxypsoralen prior to long term storage and transfusion.
摘要翻译： 描述了用于治疗旨在体内使用的材料中的污染物的方法和组合物，特别是用于人类的血液和血液制品。 血液细胞制剂中的污染物在长期储存和输血之前使用8-甲氧基补骨脂素灭活。
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公开(公告)号：US5709991A
公开(公告)日：1998-01-20
申请号：US480013
申请日：1995-06-07
申请人： Lily Lin , Laurence Corash , John Tessman , George D. Cimino , Stephen T. Isaacs
发明人： Lily Lin , Laurence Corash , John Tessman , George D. Cimino , Stephen T. Isaacs
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K35/19 , A61K41/00 , A61L2/00 , A61M1/36 , A61N5/06 , A61M35/00
CPC分类号： A61K31/365 , A01N1/0215 , A61K31/37 , A61K35/19 , A61K41/0019 , A61K41/0066 , A61L2/0011 , A61L2/0088 , A61M1/3616 , A61M1/3683 , A61M1/3686 , A61N5/06 , A61M1/3681 , A61M2202/0425 , A61M2205/053 , A61N5/062
摘要： Methods are disclosed for photodecontamination to inactivate microorganisms in platelet preparations and for removal of psoralen after photodecontamination. Removal is achieved by contacting the psoralen with a psoralen-binding polymer.
摘要翻译： 公开了用于光化学去除灭活血小板制剂中的微生物并在光蚀刻后除去补骨脂素的方法。 通过使补骨脂素与补骨脂素结合聚合物接触来实现去除。
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公开(公告)号：US5532146A
公开(公告)日：1996-07-02
申请号：US263020
申请日：1994-06-20
IPC分类号： B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： C07D493/04 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , Y10S435/81
摘要： Methods for sterilization of ligase-based amplification products, including products of the Ligation Amplification Reaction (LAR), involving treatment of nucleic acid after amplification to render such nucleic acid incapable of serving as a template for further amplification. Both random and site-specific addition of sterilizing compounds, and more specifically, photoactivation compounds, render amplification product subsequently unamplifiable. Self-sterilizing primers are also employed allowing for a homogenous detection of ligase-based amplification product.
摘要翻译： 连接酶扩增产物的灭菌方法，包括连接扩增反应（LAR）的产物，涉及在扩增后处理核酸，使得这种核酸不能作为进一步扩增的模板。 杀菌化合物，特别是光活化化合物的随机和位点特异性添加使随后的扩增产物不可扩增。 还使用自消毒引物，允许基于连接酶的扩增产物的均匀检测。
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公开(公告)号：US5665762A
公开(公告)日：1997-09-09
申请号：US462954
申请日：1995-06-05
IPC分类号： A61L2/00 , B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70 , A61K39/00 , A61K35/14 , A61K35/48
CPC分类号： C07D493/04 , A61L2/0011 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , C12Q1/6853 , C12Q1/6876 , C12Q1/703 , Y10S435/80 , Y10S435/81 , Y10S530/829
摘要： The present invention contemplates methods of decontaminating human fluids prior to processing in the clinical laboratory. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译： 本发明考虑了在临床实验室中加工之前对人体流体进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。
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5.发明授权4'-Aminomethyl- and 4'-chloromethyl-8-methoxy-4,5'-dimethylpsoralen and processes of making same 失效4'-氨基甲基 - 和4'-氯甲基-8-甲氧基-4,5'-二甲基肉桂酸酯及其制备方法
公开(公告)号：US5659050A
公开(公告)日：1997-08-19
申请号：US461493
申请日：1995-06-05
IPC分类号： A61L2/00 , B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70 , C07D493/14
CPC分类号： C07D493/04 , A61L2/0011 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , C12Q1/6853 , C12Q1/6876 , C12Q1/703 , Y10S435/80 , Y10S435/81 , Y10S530/829
摘要： The present invention contemplates methods of decontaminating human fluids prior to processing in the clinical laboratory. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译： 本发明考虑了在临床实验室中加工之前对人体流体进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。
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公开(公告)号：US06680025B2
公开(公告)日：2004-01-20
申请号：US10236373
申请日：2002-09-06
IPC分类号： A61L200
CPC分类号： B01L7/52 , B01J19/123 , B01L7/00 , C07D493/04 , C12Q1/6848 , G11C11/412 , H01L27/11 , Y10S204/902 , C12Q2523/101 , C12Q2521/531
摘要： A device containing a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.
摘要翻译： 包含光源，样品支架和温度控制室的装置。 样品支架定位成支撑多个样品容器用于照射光源。 温度控制室将样品容器的温度保持在所需的范围内。 光源，样品支架和温度控制室都包含在不透明的外壳内。
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公开(公告)号：US06461567B1
公开(公告)日：2002-10-08
申请号：US09878542
申请日：2001-06-11
IPC分类号： A61L200
CPC分类号： B01L7/52 , B01J19/123 , B01L7/00 , C07D493/04 , C12Q1/6848 , G11C11/412 , H01L27/11 , Y10S204/902 , C12Q2523/101 , C12Q2521/531
摘要： A device comprising a light source, a sample holder and a temperature control chamber. The sample holder supports the vessels in a fixed relationship relative to the light source. The temperature control chamber surrounds the sample holder and vessels, so that a temperature control fluid may be passed around the sample vessels effectively maintaining the temperature of the sample vessels within a desired temperature range.
摘要翻译： 一种包括光源，样品架和温度控制室的装置。 样品支架相对于光源以固定的关系支撑血管。 温度控制室围绕样品保持器和容器，使得温度控制流体可以有效地将样品容器的温度保持在期望的温度范围内。
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公开(公告)号：US06258319B1
公开(公告)日：2001-07-10
申请号：US09148520
申请日：1998-09-04
IPC分类号： A61L200
CPC分类号： B01L7/52 , B01J19/123 , B01L7/00 , C07D493/04 , C12Q1/6848 , G11C11/412 , H01L27/11 , Y10S204/902 , C12Q2523/101 , C12Q2521/531
摘要： A device comprising a light source, a sample holder and a temperature control chamber. The sample holder supports the vessels in a fixed relationship relative to the light source. The temperature control chamber surrounds the sample holder and vessels, so that a temperature control fluid may be passed around the sample vessels effectively maintaining the temperature of the sample vessels within a desired temperature range.
摘要翻译： 一种包括光源，样品架和温度控制室的装置。 样品支架相对于光源以固定的关系支撑血管。 温度控制室围绕样品保持器和容器，使得温度控制流体可以有效地将样品容器的温度保持在期望的温度范围内。
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公开(公告)号：US5503721A
公开(公告)日：1996-04-02
申请号：US320126
申请日：1994-10-07
IPC分类号： B01J19/12 , B01L7/00 , C07D493/04 , C07D519/00 , C12Q1/68 , G11C11/412 , H01L27/11
CPC分类号： B01L7/52 , B01J19/123 , B01L7/00 , C07D493/04 , C12Q1/6848 , G11C11/412 , H01L27/11 , Y10S204/902
摘要： A method for activating photoreactive compounds by supporting sample vessels containing a photoreactive compound at a selected temperature and irradiating the sample vessels while holding the sample vessels at a fixed relationship with the irradiating source so as to uniformly irradiate the compound.
摘要翻译： 一种通过在选定温度下支持含有光反应性化合物的样品容器来激活光反应性化合物的方法，并且在将样品容器与照射源保持固定关系的同时照射样品容器，以均匀地照射该化合物。
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公开(公告)号：US5221608A
公开(公告)日：1993-06-22
申请号：US428494
申请日：1989-10-26
IPC分类号： B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： C07D493/04 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , C12Q1/6876 , C12Q1/703 , Y10S435/808 , Y10S436/805
摘要： Method for treating nucleic acid that is to be amplified such that the nucleic acid is, after amplification, subsequently unamplifiable. Nucleic acid amplification is performed in a reaction containing means in the presence of an isopsoralen. The reaction is thereafter irradiated to render the amplified nucleic acid substantially unamplifiable.
摘要翻译： 用于处理待扩增的核酸使得核酸在扩增后随后不可扩增的方法。 在含有补骨脂素的装置中进行核酸扩增。 然后将反应物照射以使扩增的核酸基本上不可扩增。
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