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公开(公告)号：US20110142806A1
公开(公告)日：2011-06-16
申请号：US12969076
申请日：2010-12-15
CPC分类号： C12N5/0068 , A61K35/12 , A61K35/28 , A61L27/16 , A61L27/3834 , C12N11/08 , C12N13/00 , C12N2529/00 , C12N2533/30 , C08L27/16
摘要： A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
摘要翻译： 公开了制造和/或使用用于干细胞培养和组织工程应用的支架的支架组件和相关方法，其通过使用电活性材料提供生物化学，地形学，机械和电学提示，至少部分地模拟天然生物环境。 该组件包括至少一层基本对准的电纺聚合物纤维，其具有用于单独电压施加的操作连接。 细胞组织工程和/或干细胞分化的方法利用悬浮在细胞培养基中的细胞样品接种组合物，孵育并施加电压至一层或多层，从而产生细胞和/或组织构建体。 另一方面，本发明提供一种制造组件的方法，其包括以下步骤：提供第一预电镀基底表面; 将第一基本上排列的聚合物纤维层静电纺丝到第一表面上; 提供第二预电镀衬底表面; 将第二基本上排列的聚合物纤维层静电纺丝到第二表面上; 并且用夹具和/或粘合剂化合物将层压表面保持在一起。
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2.发明授权公开(公告)号：US09005604B2
公开(公告)日：2015-04-14
申请号：US12969076
申请日：2010-12-15
CPC分类号： C12N5/0068 , A61K35/12 , A61K35/28 , A61L27/16 , A61L27/3834 , C12N11/08 , C12N13/00 , C12N2529/00 , C12N2533/30 , C08L27/16
摘要： A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
摘要翻译： 公开了制造和/或使用用于干细胞培养和组织工程应用的支架的支架组件和相关方法，其通过使用电活性材料提供生物化学，地形学，机械和电学提示，至少部分地模拟天然生物环境。 该组件包括至少一层基本对准的电纺聚合物纤维，其具有用于单独电压施加的操作连接。 细胞组织工程和/或干细胞分化的方法利用悬浮在细胞培养基中的细胞样品接种组合物，孵育并施加电压至一层或多层，从而产生细胞和/或组织构建体。 另一方面，本发明提供一种制造组件的方法，其包括以下步骤：提供第一预电镀基底表面; 将第一基本上排列的聚合物纤维层静电纺丝到第一表面上; 提供第二预电镀衬底表面; 将第二基本上排列的聚合物纤维层静电纺丝到第二表面上; 并且用夹具和/或粘合剂化合物将层压表面保持在一起。
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公开(公告)号：US10406346B2
公开(公告)日：2019-09-10
申请号：US12699334
申请日：2010-02-03
摘要： A method and device for promoting healing of an injury in a living being are provided. Such method and device are based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.
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4.发明授权Structural health monitoring system/method using electroactive polymer fibers 有权使用电活性聚合物纤维的结构健康监测系统/方法公开(公告)号：US08378659B2
公开(公告)日：2013-02-19
申请号：US12703221
申请日：2010-02-10
IPC分类号： G01N27/00
CPC分类号： G01M5/0041 , G01M5/0083
摘要： A method for monitoring the structural health of a structure of interest by coupling one or more electroactive polymer fibers to the structure and monitoring the electroactive responses of the polymer fiber(s). Load changes that are experienced by the structure cause changes in the baseline responses of the polymer fiber(s). A system for monitoring the structural health of the structure is also provided.
摘要翻译： 一种通过将一种或多种电活性聚合物纤维耦合到结构并监测聚合物纤维的电活性响应来监测感兴趣结构的结构健康的方法。 结构经历的负荷变化导致聚合物纤维的基线响应的变化。 还提供了一种用于监测结构的结构健康的系统。
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公开(公告)号：US07993567B2
公开(公告)日：2011-08-09
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译： 提供了一种用于在静电纺丝过程中对准纤维的方法和系统。 可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。 当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。 该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。 可以使用分配器，收集器和电极的数字和几何形状的各种组合。
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6.发明申请Structural Health Monitoring System/Method Using Electroactive Polymer Fibers 有权结构健康监测系统/使用电聚合物纤维的方法公开(公告)号：US20100201384A1
公开(公告)日：2010-08-12
申请号：US12703221
申请日：2010-02-10
IPC分类号： G01R27/08
CPC分类号： G01M5/0041 , G01M5/0083
摘要： One or more electroactive polymer fibers are coupled to a structure. Electroactive responses of the fiber(s) are monitored. Load changes experienced by the structure cause changes in baseline responses of the fiber(s)
摘要翻译： 一种或多种电活性聚合物纤维与结构偶联。 监测纤维的电活性响应。 结构负荷变化会导致光纤的基线响应发生变化
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公开(公告)号：US20090108503A1
公开(公告)日：2009-04-30
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译： 提供了一种用于在静电纺丝过程中对准纤维的方法和系统。 可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。 当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。 该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。 可以使用分配器，收集器和电极的数字和几何形状的各种组合。
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8.发明授权Nanocomposites from stable dispersions of carbon nanotubes in polymeric matrices using dispersion interaction 有权使用分散相互作用从碳纳米管在聚合物基质中稳定分散的纳米复合材料公开(公告)号：US09493635B2
公开(公告)日：2016-11-15
申请号：US11644019
申请日：2006-12-22
CPC分类号： C08K7/24 , B82Y30/00 , C08K2201/011
摘要： Stable dispersions of carbon nanotubes (CNTs) in polymeric matrices include CNTs dispersed in a host polymer or copolymer whose monomers have delocalized electron orbitals, so that a dispersion interaction results between the host polymer or copolymer and the CNTs dispersed therein. Nanocomposite products, which are presented in bulk, or when fabricated as a film, fiber, foam, coating, adhesive, paste, or molding, are prepared by standard means from the present stable dispersions of CNTs in polymeric matrices, employing dispersion interactions, as presented hereinabove.
摘要翻译： 碳纳米管（CNTs）在聚合物基质中的稳定分散体包括分散在其单体具有离域电子轨道的主体聚合物或共聚物中的CNT，使得在主体聚合物或共聚物与分散在其中的CNT之间产生分散相互作用。 通过标准方法通过标准方法制备纳米复合材料，其以体积呈现，或当制成膜，纤维，泡沫，涂层，粘合剂，糊剂或模塑时，由CNT在聚合物基质中的稳定分散体采用分散相互作用，如 如上所述。
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公开(公告)号：US20110192319A1
公开(公告)日：2011-08-11
申请号：US13032045
申请日：2011-02-22
CPC分类号： C08K7/24 , B82Y30/00 , C08K2201/011
摘要： Conventional toughening agents are typically rubbery materials or small molecular weight molecules, which mostly sacrifice the intrinsic properties of a matrix such as modulus, strength, and thermal stability as side effects. On the other hand, high modulus inclusions tend to reinforce elastic modulus very efficiently, but not the strength very well. For example, mechanical reinforcement with inorganic inclusions often degrades the composite toughness, encountering a frequent catastrophic brittle failure triggered by minute chips and cracks. Thus, toughening generally conflicts with mechanical reinforcement. Carbon nanotubes have been used as efficient reinforcing agents in various applications due to their combination of extraordinary mechanical, electrical, and thermal properties. Moreover, nanotubes can elongate more than 20% without yielding or breaking, and absorb significant amounts of energy during deformation, which enables them to also be an efficient toughening agent, as well as excellent reinforcing inclusion. Accordingly, an improved toughening method is provided by incorporating nanotubular inclusions into a host matrix, such as thermoset and thermoplastic polymers or ceramics without detrimental effects on the matrix's intrinsic physical properties.
摘要翻译： 常规增韧剂通常是橡胶状材料或小分子量分子，其主要牺牲基质的固有性质，例如作为副作用的模量，强度和热稳定性。 另一方面，高模量夹杂物倾向于非常有效地增强弹性模量，但是强度非常好。 例如，具有无机夹杂物的机械增强剂常常降低复合材料的韧性，遇到由碎片和裂纹引起的频繁的灾难性脆性破坏。 因此，增韧通常与机械加强冲突。 碳纳米管由于其非凡的机械，电气和热性能的组合，已经在各种应用中用作有效的增强剂。 此外，纳米管可以延伸超过20％而不产生或破裂，并且在变形期间吸收大量的能量，这使得它们也可以是有效的增韧剂，以及优异的增强夹杂物。 因此，通过将纳米管状夹杂物结合到主体基质如热固性和热塑性聚合物或陶瓷中而不会对基体的固有物理性质产生不利影响，提供了改进的增韧方法。
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10.发明申请公开(公告)号：US20110169187A1
公开(公告)日：2011-07-14
申请号：US13053633
申请日：2011-03-22
CPC分类号： C08K7/24 , B82Y30/00 , C08K2201/011
摘要： A nanocomposite structure and method of fabricating same are provided. The nanocomposite structure is a polymer in an extruded shape with carbon nanotubes (CNTs) longitudinally disposed and dispersed in the extruded shape along a dimension thereof. The polymer is characteristically defined as having a viscosity of at least approximately 100,000 poise at a temperature of 200° C.
摘要翻译： 提供纳米复合结构及其制造方法。 纳米复合结构是挤出形状的聚合物，其中碳纳米管（CNT）沿其尺寸纵向设置并分散在挤出形状中。 该聚合物特征定义为在200℃的温度下具有至少约100,000泊的粘度。
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