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公开(公告)号：US20110142806A1
公开(公告)日：2011-06-16
申请号：US12969076
申请日：2010-12-15
CPC分类号： C12N5/0068 , A61K35/12 , A61K35/28 , A61L27/16 , A61L27/3834 , C12N11/08 , C12N13/00 , C12N2529/00 , C12N2533/30 , C08L27/16
摘要： A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
摘要翻译： 公开了制造和/或使用用于干细胞培养和组织工程应用的支架的支架组件和相关方法，其通过使用电活性材料提供生物化学，地形学，机械和电学提示，至少部分地模拟天然生物环境。 该组件包括至少一层基本对准的电纺聚合物纤维，其具有用于单独电压施加的操作连接。 细胞组织工程和/或干细胞分化的方法利用悬浮在细胞培养基中的细胞样品接种组合物，孵育并施加电压至一层或多层，从而产生细胞和/或组织构建体。 另一方面，本发明提供一种制造组件的方法，其包括以下步骤：提供第一预电镀基底表面; 将第一基本上排列的聚合物纤维层静电纺丝到第一表面上; 提供第二预电镀衬底表面; 将第二基本上排列的聚合物纤维层静电纺丝到第二表面上; 并且用夹具和/或粘合剂化合物将层压表面保持在一起。
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2.发明授权公开(公告)号：US09005604B2
公开(公告)日：2015-04-14
申请号：US12969076
申请日：2010-12-15
CPC分类号： C12N5/0068 , A61K35/12 , A61K35/28 , A61L27/16 , A61L27/3834 , C12N11/08 , C12N13/00 , C12N2529/00 , C12N2533/30 , C08L27/16
摘要： A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.
摘要翻译： 公开了制造和/或使用用于干细胞培养和组织工程应用的支架的支架组件和相关方法，其通过使用电活性材料提供生物化学，地形学，机械和电学提示，至少部分地模拟天然生物环境。 该组件包括至少一层基本对准的电纺聚合物纤维，其具有用于单独电压施加的操作连接。 细胞组织工程和/或干细胞分化的方法利用悬浮在细胞培养基中的细胞样品接种组合物，孵育并施加电压至一层或多层，从而产生细胞和/或组织构建体。 另一方面，本发明提供一种制造组件的方法，其包括以下步骤：提供第一预电镀基底表面; 将第一基本上排列的聚合物纤维层静电纺丝到第一表面上; 提供第二预电镀衬底表面; 将第二基本上排列的聚合物纤维层静电纺丝到第二表面上; 并且用夹具和/或粘合剂化合物将层压表面保持在一起。
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公开(公告)号：US07993567B2
公开(公告)日：2011-08-09
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译： 提供了一种用于在静电纺丝过程中对准纤维的方法和系统。 可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。 当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。 该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。 可以使用分配器，收集器和电极的数字和几何形状的各种组合。
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公开(公告)号：US20090108503A1
公开(公告)日：2009-04-30
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译： 提供了一种用于在静电纺丝过程中对准纤维的方法和系统。 可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。 当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。 该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。 可以使用分配器，收集器和电极的数字和几何形状的各种组合。
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5.发明申请Sensing/Actuating Materials Made From Carbon Nanotube Polymer Composites and Methods for Making Same 有权由碳纳米管聚合物复合材料制成的感应/致动材料及其制造方法公开(公告)号：US20080287589A1
公开(公告)日：2008-11-20
申请号：US12109490
申请日：2008-04-25
IPC分类号： C08K3/04
CPC分类号： B82Y30/00 , C01B32/158 , H01L41/183 , Y10S977/783 , Y10S977/832 , Y10T428/25 , Y10T428/252 , Y10T428/256 , Y10T428/258
摘要： An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electromechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.
摘要翻译： 电活性感测或致动材料包括由具有可极化部分的聚合物制成的复合材料，并且当这种复合材料受外部刺激影响时，有效量的纳入聚合物中的碳纳米管用于组合物的预定机电操作。 在另一个实施方案中，所述复合材料包括还掺入聚合物基质中的电活性陶瓷的微尺寸至纳米尺寸颗粒的第三组分。 制备三相复合材料的方法包括在引入陶瓷颗粒之前将碳纳米管掺入聚合物基质中，或者在引入到聚合物基质中之前将碳纳米管和陶瓷颗粒一起混合在溶液中。
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6.发明授权Sensing/actuating materials made from carbon nanotube polymer composites and methods for making same 有权由碳纳米管聚合物复合材料制成的感应/致动材料及其制造方法公开(公告)号：US07402264B2
公开(公告)日：2008-07-22
申请号：US11076460
申请日：2005-03-03
CPC分类号： B82Y30/00 , C01B32/158 , H01L41/183 , Y10S977/783 , Y10S977/832 , Y10T428/25 , Y10T428/252 , Y10T428/256 , Y10T428/258
摘要： An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.
摘要翻译： 电活性感测或致动材料包括由具有可极化部分的聚合物制成的复合材料，并且当这种复合材料受外部刺激影响时，将有效量的纳入聚合物中的碳纳米管用于组合物的预定电机操作。 在另一个实施方案中，所述复合材料包括还掺入聚合物基质中的电活性陶瓷的微尺寸至纳米尺寸颗粒的第三组分。 制备三相复合材料的方法包括在引入陶瓷颗粒之前将碳纳米管掺入聚合物基质中，或者在引入到聚合物基质中之前将碳纳米管和陶瓷颗粒一起混合在溶液中。
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7.发明授权Method of making an electroactive sensing/actuating material for carbon nanotube polymer composite 有权制备用于碳纳米管聚合物复合材料的电活性感应/致动材料的方法公开(公告)号：US07527751B2
公开(公告)日：2009-05-05
申请号：US12109490
申请日：2008-04-25
IPC分类号： H01B1/00
CPC分类号： B82Y30/00 , C01B32/158 , H01L41/183 , Y10S977/783 , Y10S977/832 , Y10T428/25 , Y10T428/252 , Y10T428/256 , Y10T428/258
摘要： An electroactive sensing or actuating material comprises a composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electromechanical operation of the composite when such composite is affected by an external stimulus. In another embodiment, the composite comprises a third component of micro-sized to nano-sized particles of an electroactive ceramic that is also incorporated in the polymer matrix. The method for making the three-phase composite comprises either incorporating the carbon nanotubes in the polymer matrix before incorporation of the particles of ceramic or mixing the carbon nanotubes and particles of ceramic together in a solution before incorporation in the polymer matrix.
摘要翻译： 电活性感测或致动材料包括由具有可极化部分的聚合物制成的复合材料，并且当这种复合材料受外部刺激影响时，有效量的纳入聚合物中的碳纳米管用于组合物的预定机电操作。 在另一个实施方案中，所述复合材料包括还掺入聚合物基质中的电活性陶瓷的微尺寸至纳米尺寸颗粒的第三组分。 制备三相复合材料的方法包括在引入陶瓷颗粒之前将碳纳米管掺入聚合物基质中，或者在引入到聚合物基质中之前将碳纳米管和陶瓷颗粒一起混合在溶液中。
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8.发明授权Multilayer electroactive polymer composite material comprising carbon nanotubes 有权包含碳纳米管的多层电活性聚合物复合材料公开(公告)号：US07507472B2
公开(公告)日：2009-03-24
申请号：US11081888
申请日：2005-03-09
IPC分类号： B32B5/16
CPC分类号： B32B27/08 , B32B27/20 , B32B2307/204 , B82Y30/00 , H01L41/183 , Y10S977/783 , Y10S977/832 , Y10T428/24355 , Y10T428/24372 , Y10T428/24942 , Y10T428/25 , Y10T428/252 , Y10T428/256 , Y10T428/258 , Y10T428/31551 , Y10T428/31721 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
摘要： An electroactive material comprises multiple layers of electroactive composite with each layer having unique dielectric, electrical and mechanical properties that define an electromechanical operation thereof when affected by an external stimulus. For example, each layer can be (i) a 2-phase composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation, or (ii) a 3-phase composite having the elements of the 2-phase composite and further including a third component of micro-sized to nano-sized particles of an electroactive ceramic incorporated in the polymer matrix.
摘要翻译： 电活性材料包括多层电活性复合材料，每层具有独特的电介质，电学和机械性能，当受到外部刺激的影响时，其定义了机电操作。 例如，每个层可以是（i）由具有可极化部分的聚合物制成的2相复合物，并且在预定的电子机械操作中引入掺入聚合物中的有效量的碳纳米管，或（ii）具有 并且还包括掺入聚合物基质中的电活性陶瓷的微尺寸至纳米尺寸颗粒的第三组分。
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公开(公告)号：US07935414B2
公开(公告)日：2011-05-03
申请号：US12406315
申请日：2009-03-18
IPC分类号： B32B5/16
CPC分类号： B32B27/08 , B32B27/20 , B32B2307/204 , B82Y30/00 , H01L41/183 , Y10S977/783 , Y10S977/832 , Y10T428/24355 , Y10T428/24372 , Y10T428/24942 , Y10T428/25 , Y10T428/252 , Y10T428/256 , Y10T428/258 , Y10T428/31551 , Y10T428/31721 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935
摘要： An electroactive material comprises multiple layers of electroactive composite with each layer having unique dielectric, electrical and mechanical properties that define an electromechanical operation thereof when affected by an external stimulus. For example, each layer can be (i) a 2-phase composite made from a polymer with polarizable moieties and an effective amount of carbon nanotubes incorporated in the polymer for a predetermined electomechanical operation, or (ii) a 3-phase composite having the elements of the 2-phase composite and further including a third component of micro-sized to nano-sized particles of an electroactive ceramic incorporated in the polymer matrix.
摘要翻译： 电活性材料包括多层电活性复合材料，每层具有独特的电介质，电学和机械性能，当受到外部刺激的影响时，其定义了机电操作。 例如，每个层可以是（i）由具有可极化部分的聚合物制成的2相复合物，并且在预定的电子机械操作中引入掺入聚合物中的有效量的碳纳米管，或（ii）具有 并且还包括掺入聚合物基质中的电活性陶瓷的微尺寸至纳米尺寸颗粒的第三组分。
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10.发明授权Multi-channel electronically scanned cryogenic pressure sensor and method for making same 失效多通道电子扫描低温压力传感器及其制作方法公开(公告)号：US06247369B1
公开(公告)日：2001-06-19
申请号：US09229931
申请日：1999-01-13
IPC分类号： G01L904
CPC分类号： G01L19/04 , G01L9/0054 , G01L9/065
摘要： A miniature, multi-channel, electronically scanned pressure measuring device uses electrostatically bonded silicon dies in a multi-element array. These dies are bonded at specific sites on a glass, pre-patterned substrate. Thermal data is multiplexed and recorded on each individual pressure measuring diaphragm. The device functions in a cryogenic environment without the need of heaters to keep the sensor at constant temperatures.
摘要翻译： 微型多通道电子扫描压力测量装置在多元件阵列中使用静电键合的硅模具。 这些模具在玻璃上预定图案化的基底上的特定部位结合。 热量数据被复用并记录在每个单独的压力测量膜片上。 该器件在低温环境中起作用，无需加热器将传感器保持在恒定温度。
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