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1.发明授权Method for the production of resveratrol in a recombinant oleaginous microorganism 有权在重组油性微生物中生产白藜芦醇的方法公开(公告)号：US07772444B2
公开(公告)日：2010-08-10
申请号：US11436182
申请日：2006-05-17
申请人： Lixuan Lisa Huang , Zhixiong Xue , Quinn Qun Zhu
发明人： Lixuan Lisa Huang , Zhixiong Xue , Quinn Qun Zhu
IPC分类号： A61K31/7034 , A61K31/05 , C07C39/04 , C07H15/203
CPC分类号： C12P7/22 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815
摘要： Methods to produce resveratrol and/or resveratrol glucoside in a recombinant oleaginous microorganism are provided. Expression of a resveratrol synthase gene in combination with genes involved in the phenylpropanoid pathway enabled recombinant microbial production of resveratrol in significant amounts.
摘要翻译： 提供了在重组含油微生物中产生白藜芦醇和/或白藜芦醇葡糖苷的方法。 白藜芦醇合酶基因与参与苯丙素途径的基因组合的表达使得白藜芦醇的重组微生物产生显着。
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2.发明申请Method for the production of resveratrol in a recombinant oleaginous microorganism 有权在重组油性微生物中生产白藜芦醇的方法公开(公告)号：US20090082286A1
公开(公告)日：2009-03-26
申请号：US11436182
申请日：2006-05-17
申请人： Lixuan Lisa Huang , Zhixiong Xue , Quinn Qun Zhu
发明人： Lixuan Lisa Huang , Zhixiong Xue , Quinn Qun Zhu
CPC分类号： C12P7/22 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815
摘要： Methods to produce resveratrol and/or resveratrol glucoside in a recombinant oleaginous microorganism are provided. Expression of a resveratrol synthase gene in combination with genes involved in the phenylpropanoid pathway enabled recombinant microbial production of resveratrol in significant amounts.
摘要翻译： 提供了在重组含油微生物中产生白藜芦醇和/或白藜芦醇葡糖苷的方法。 白藜芦醇合酶基因与参与苯丙素途径的基因组合的表达使得白藜芦醇的重组微生物产生显着。
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3.发明授权Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids 有权突变型HPGG基序和HDASH基序delta-5去饱和酶及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08658413B2
公开(公告)日：2014-02-25
申请号：US13218673
申请日：2011-08-26
申请人： Melissa D. Bosak , Michael W. Bostick , Hongxian He , Seung-Pyo Hong , Dana M. Walters Pollak , Pamela L. Sharpe , Yehong Jamie Wang , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
发明人： Melissa D. Bosak , Michael W. Bostick , Hongxian He , Seung-Pyo Hong , Dana M. Walters Pollak , Pamela L. Sharpe , Yehong Jamie Wang , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
CPC分类号： C12N9/001 , C12P7/6472 , C12Y103/01035
摘要： Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”], are also disclosed.
摘要翻译： 具有将dihomo-γ-亚麻酸转化的能力的变体delta-5去饱和酶[DGLA; 20：3ω-6]花生四烯酸[ARA; 20：4ω-6]和/或二十碳四烯酸[ETA; 20：4ω-3]至二十碳五烯酸[EPA; 20：5ω-3]，并且在细胞色素b5样结构域的HPGG（SEQ ID NO：7）基序和HDASH（SEQ ID NO：8）基序内的至少一个突变中具有至少一个突变。 还公开了分离的核酸片段和包含编码Δ-5去饱和酶的片段的重组构建物，以及制备长链多不饱和脂肪酸[“PUFA”]的方法。
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4.发明申请DELTA 17 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA 17去饱和及其在制备聚氨酯脂肪酸中的应用公开(公告)号：US20130011846A1
公开(公告)日：2013-01-10
申请号：US13535775
申请日：2012-06-28
申请人： Narendra S. Yadav , Zhixiong Xue , Quinn Qun Zhu
发明人： Narendra S. Yadav , Zhixiong Xue , Quinn Qun Zhu
CPC分类号： C12P7/6427 , C12N9/0083 , C12P7/6472
摘要： The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ17 desaturases in oleaginous yeast are disclosed.
摘要翻译： 本发明涉及具有将ω-6脂肪酸转化成其ω-3对应物的能力（即将花生四烯酸[20:4，ARA]转化为二十碳五烯酸[20:5，EPA ]）。 公开了分离的核酸片段和重组构建体，其包含编码＆amp; 17去饱和酶的这种片段以及使用这些在油性酵母中的这些＆Dgr.17去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US08313911B2
公开(公告)日：2012-11-20
申请号：US12641929
申请日：2009-12-18
CPC分类号： C12P7/6427
摘要： Methods for the production of omega-3 and/or omega-6 fatty acids in oleaginous yeasts grown on a fermentable carbon source selected from the group consisting of invert sucrose, glucose, fructose and combinations of these, provided that glucose is used in combination with invert sucrose and/or fructose. Specifically, methods are provided for production of linoleic acid, eicosadienoic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, n-6 docosapentaenoic acid, α-linolenic acid, stearidonic acid, eicosatrienoic acid, eicosatetraenoic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid.
摘要翻译： 在选自蔗糖，葡萄糖，果糖及其组合的可发酵碳源上生长的油质酵母中生产ω-3和/或ω-6脂肪酸的方法，其中葡萄糖与 反转蔗糖和/或果糖。 具体地说，提供了用于生产亚油酸，二十碳二烯酸，γ-亚麻酸，二高-γ-亚麻酸，花生四烯酸，n-6二十二碳五烯酸，α-亚麻酸，十八碳四烯酸，二十碳三烯酸，二十碳四烯酸，二十碳五烯酸 酸，二十二碳五烯酸和二十二碳六烯酸。
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6.发明申请YARROWIA DIACYLGLYCEROL ACYLTRANSFERASE PROMOTER REGIONS FOR GENE EXPRESSION IN YEAST 有权YARROWIA DIACYLGLYCEROL ACYLTRANSFERASE促销区域用于基因表达在YEAST公开(公告)号：US20120252079A1
公开(公告)日：2012-10-04
申请号：US13435246
申请日：2012-03-30
申请人： Quinn Qun Zhu , Zhixiong Xue
发明人： Quinn Qun Zhu , Zhixiong Xue
IPC分类号： C12P7/64 , C12N15/113 , C12N1/19
CPC分类号： C12N15/815 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y203/0102
摘要： Promoter regions associated with the Yarrowia lipolytica diacylglycerol acyltransferase 2 (dgat2) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.
摘要翻译： 公开了与解脂耶氏酵母双酰基甘油酰基转移酶2（dgat2）基因相关的启动子区域，并且已经发现其对酵母中异源基因的表达特别有效。 这些启动子区域可用于驱动涉及ω-3和ω-6脂肪酸生产的基因的高水平表达。
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公开(公告)号：US08241884B2
公开(公告)日：2012-08-14
申请号：US12469208
申请日：2009-05-20
申请人： Narendra S. Yadav , Zhixiong Xue , Quinn Qun Zhu
发明人： Narendra S. Yadav , Zhixiong Xue , Quinn Qun Zhu
IPC分类号： C12N1/16
CPC分类号： C12P7/6427 , C12N9/0083 , C12P7/6472
摘要： The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ17 desaturases in oleaginous yeast are disclosed.
摘要翻译： 本发明涉及具有将ω-6脂肪酸转化成其ω-3对应物的能力（即将花生四烯酸[20:4，ARA]转化为二十碳五烯酸[20:5，EPA ]）。 公开了分离的核酸片段和重组构建体，其包含编码＆amp; 17去饱和酶的这种片段以及使用这些在油性酵母中的这些＆Dgr.17去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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8.发明授权Microbial oils produced in transformed host cells comprising delta-9 elongases 有权在包含δ-9延伸酶的转化宿主细胞中产生的微生物油公开(公告)号：US08048653B2
公开(公告)日：2011-11-01
申请号：US12619706
申请日：2009-11-17
CPC分类号： C12N15/8247 , C11B1/025 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472
摘要： The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in plants and oleaginous yeast are disclosed.
摘要翻译： 本发明涉及具有将亚油酸[18：2，LA]转化成二十碳烯酸[20：2，EDA]的能力的“Dgr”9延伸酶。 公开了分离的核酸片段和重组构建体，其包含编码'Dgr 9延长酶的这种片段以及使用这些植物和油性酵母中的这些Dgr 9延伸酶制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US07932077B2
公开(公告)日：2011-04-26
申请号：US11265761
申请日：2005-11-02
申请人： Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
发明人： Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K. Picataggio , Dana M. Walters Pollak , James John Ragghianti , Zhixiong Xue , Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
摘要： Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.
摘要翻译： 描述了能够在总油馏分中产生大于25％二十碳五烯酸（EPA，ω-3多不饱和脂肪酸）的含油酵母解脂耶氏酵母解脂耶氏酵母菌的工程菌株。 这些菌株包括表达异源去饱和酶，延伸酶和酰基转移酶的各种嵌合基因，并且任选地包含各种天然去饱和酶和酰基转移酶敲除，以使EPA能够合成和高度积累。 要求生产宿主细胞，以及在所述宿主细胞内生产EPA的方法。
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公开(公告)号：US20110016581A1
公开(公告)日：2011-01-20
申请号：US12445633
申请日：2007-10-22
申请人： Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
发明人： Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
IPC分类号： C12N15/82 , C07H21/00 , C12N9/02 , C12N15/63 , C12N5/10 , A01H5/00 , A01H5/10 , C07F9/10 , C12P7/64 , C07C57/02 , A23L1/20 , A23K1/00
CPC分类号： C12N15/8247 , A23K20/158 , A23L33/12 , C12N9/0083
摘要： Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-8 desaturases in plants and oleaginous yeast.
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