公开(公告)号：US06687395B1

公开(公告)日：2004-02-03

申请号：US09558094

申请日：2000-04-26

申请人： Louis J. Dietz ,  Ian Walton ,  Chih-Hua Chung ,  Scott Norton ,  James L. Winkler ,  Aaron B. Kantor ,  Byron Lee ,  Shalom Tsur

发明人： Louis J. Dietz ,  Ian Walton ,  Chih-Hua Chung ,  Scott Norton ,  James L. Winkler ,  Aaron B. Kantor ,  Byron Lee ,  Shalom Tsur

IPC分类号： G06K900

CPC分类号： G01N15/1475

摘要： The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

公开(公告)号：US06753135B2

公开(公告)日：2004-06-22

申请号：US09956757

申请日：2001-09-20

申请人： Susan E. Alters ,  Karen L. Cheal ,  Aaron B. Kantor

发明人： Susan E. Alters ,  Karen L. Cheal ,  Aaron B. Kantor

IPC分类号： C12Q100

CPC分类号： G01N33/5094 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2333/70535 ,  G01N2800/52

摘要： Novel biological markers indicative of the action of an anti-inflammatory or immunosuppressive drug can be used to evaluate drug efficacy and compare local and systemic drug effects. They can also aid in comparison of different drugs, doses, and delivery routes. The biological markers include cell populations, cell surface antigen expression levels, and soluble factor concentrations. Measurement values of the novel biomarkers were shown to change significantly in allergic, atopic asthmatic, and healthy subjects after administration of prednisone.

摘要翻译： 可以使用指示抗炎或免疫抑制药物作用的新型生物标志物来评估药物功效并比较局部和全身药物作用。 他们也可以帮助比较不同的药物，剂量和分娩途径。 生物标志物包括细胞群，细胞表面抗原表达水平和可溶性因子浓度。 在施用泼尼松后，新生物标志物的测量值显示在过敏性，特应性哮喘和健康受试者中显着变化。

公开(公告)号：US07248360B2

公开(公告)日：2007-07-24

申请号：US11090673

申请日：2005-03-25

申请人： Uwe Horchner ,  Aaron B. Kantor

发明人： Uwe Horchner ,  Aaron B. Kantor

IPC分类号： G01J3/30 ,  G01J3/28 ,  G01J3/44 ,  G01J3/40 ,  G01J1/58 ,  F21V9/16 ,  G01T1/10 ,  G21H3/02 ,  G21K5/00 ,  H01J65/06 ,  H01J65/08

CPC分类号： G01J3/2803 ,  G01J3/44 ,  G01N15/1434 ,  G01N21/6428 ,  G01N21/658 ,  G01N2015/008 ,  G01N2015/144 ,  G01N2021/6482

摘要： A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other suspensions. In accordance with embodiments of the present invention, the system comprises a scanner to direct an excitation laser through a sample, an objective to collect light emitted by the sample in response to the excitation laser, a spectrograph to disperse the emitted light over a plurality of wavelengths as a spectrum, and a charge coupled device for detecting the spectrum. The system can be used with samples having a variety of reporter tags, including one or more SERS tags, fluorescent organic and protein tags, and quantum dot tags. A laser scanning apparatus and method of using the same is also provided.

摘要翻译： 用于激光扫描的系统提供了高分辨率样品的光谱监测所需的光谱灵活性，例如全血或其它悬浮液中的细胞和颗粒测定。 根据本发明的实施例，该系统包括扫描器，用于将激发激光引导通过样本，用于响应于激发激光收集由样本发射的光的目标，将发射的光分散在多个 波长作为光谱，以及用于检测光谱的电荷耦合器件。 该系统可以与具有各种报告标签的样品一起使用，包括一个或多个SERS标签，荧光有机和蛋白质标签以及量子点标签。 还提供了一种激光扫描装置及其使用方法。

公开(公告)号：US20100062471A1

公开(公告)日：2010-03-11

申请号：US12088228

申请日：2006-09-29

申请人： Aaron B. Kantor ,  Susan Goelz ,  Jun Deng ,  Hua Lin ,  Christopher Becker

发明人： Aaron B. Kantor ,  Susan Goelz ,  Jun Deng ,  Hua Lin ,  Christopher Becker

IPC分类号： C12Q1/02

CPC分类号： G01N33/5091 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5047 ,  G01N33/564 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/285 ,  G01N2800/52

摘要： Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing MS, relapse of MS patients and disease progression in MS patients.

摘要翻译： 提供了用于识别多发性硬化症（MS）患者治疗和监测治疗的生物标志物，以及其鉴定方法，MS诊断方法，MS患者复发和MS患者疾病进展。

公开(公告)号：US07387880B2

公开(公告)日：2008-06-17

申请号：US11075024

申请日：2005-03-07

申请人： Timothy L. Wyant ,  Paul A. Raju ,  Aaron B. Kantor

发明人： Timothy L. Wyant ,  Paul A. Raju ,  Aaron B. Kantor

IPC分类号： G01N33/53 ,  G01N1/00

CPC分类号： G01N33/86 ,  G01N15/1468 ,  G01N15/1484 ,  G01N2015/0084 ,  G01N2015/1465 ,  G01N2015/1472 ,  G01N2015/1486 ,  Y10T436/108331 ,  Y10T436/24 ,  Y10T436/2525

摘要： The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry.

摘要翻译： 样品中血小板表面蛋白的量可以通过将含有血小板的样品收集到含有血小板稳定组合物的收集管中，标记血小板表面蛋白并通过细胞计数进行检测来测量。

公开(公告)号：US06924114B2

公开(公告)日：2005-08-02

申请号：US09957624

申请日：2001-09-20

申请人： Timothy L. Wyant ,  Paul A. Raju ,  Aaron B. Kantor

发明人： Timothy L. Wyant ,  Paul A. Raju ,  Aaron B. Kantor

IPC分类号： G01N15/00 ,  G01N15/14 ,  G01N33/86 ,  G01N33/53 ,  G01N1/00

CPC分类号： G01N33/86 ,  G01N15/1468 ,  G01N15/1484 ,  G01N2015/0084 ,  G01N2015/1465 ,  G01N2015/1472 ,  G01N2015/1486 ,  Y10T436/108331 ,  Y10T436/24 ,  Y10T436/2525

摘要： The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry.

摘要翻译： 样品中血小板表面蛋白的量可以通过将含有血小板的样品收集到含有血小板稳定组合物的收集管中，标记血小板表面蛋白并通过细胞计数进行检测来测量。