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公开(公告)号：US07736906B2
公开(公告)日：2010-06-15
申请号：US10172939
申请日：2002-06-17
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： G01N1/28
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodologies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光定向方法组合。
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公开(公告)号：US07691330B1
公开(公告)日：2010-04-06
申请号：US09579982
申请日：2000-05-26
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01L3/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。 该方法可以与光导方法组合。
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公开(公告)号：US06705754B2
公开(公告)日：2004-03-16
申请号：US10062431
申请日：2002-01-30
申请人： James L. Winkler , Mark Chee , David Lockhart
发明人： James L. Winkler , Mark Chee , David Lockhart
IPC分类号： B01F1100
CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809
摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.
摘要翻译： 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。
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公开(公告)号：US5489678A
公开(公告)日：1996-02-06
申请号：US390272
申请日：1995-02-16
申请人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
发明人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
摘要翻译： 创造大规模化学多样性的综合战略。 使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。 在一个实施例中使用二进制掩蔽技术。 还公开了反应器系统，可光除保护组和改进的数据收集和处理技术。 还提供了筛选接头分子的技术。
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5.发明授权Very large scale immobilized polymer synthesis using mechanically directed flow paths 失效使用机械定向流动路径的非常大规模的固定化聚合物合成
公开(公告)号：US5384261A
公开(公告)日：1995-01-24
申请号：US796243
申请日：1991-11-22
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N33/543
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/045 , C07K1/047 , G01N35/1072 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S435/968 , Y10S435/969 , Y10S435/97 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T436/143333
摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。 根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。 选定的试剂流过通道，衬底通过旋转阶段（403）旋转，并重复该过程以在衬底上形成聚合物阵列。 该方法可以与光导方法组合。
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公开(公告)号：US20090143249A1
公开(公告)日：2009-06-04
申请号：US12265048
申请日：2008-11-05
IPC分类号： C40B50/08
CPC分类号： B01L3/502715 , B01F13/0059 , B01F13/02 , B01F13/08 , B01J19/0046 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2400/0487 , B82Y30/00 , C07H21/00 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/54366 , G01N2035/00158 , Y10S435/97 , Y10S435/973 , Y10S436/809 , Y10T436/112499
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
摘要翻译： 具有空腔310的主体300，其具有根据美国专利No. 提供了第5,143,854号和PCT WO 92/10092等。 空腔包括用于将选定流体引入空腔中以接触探针的入口350和360。 因此，提供了用于高通量测定系统的商业上可行的装置。
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公开(公告)号：US07336812B2
公开(公告)日：2008-02-26
申请号：US10771585
申请日：2004-02-03
申请人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur
发明人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur
CPC分类号： G01N15/1475
摘要： The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.
摘要翻译： 本发明提供了用于生物标志物鉴定的改进的集成系统。 该系统使用微量激光扫描显微镜（MLSC）来测量生物液体中生物标志物的表达模式。 该系统包括用于执行MLSC的改进仪器，还包括改进的粒子检测和分析方法。 该系统还包括用于分析从MLSC获得的数据与其他医疗信息的信息架构。
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公开(公告)号：US07125161B2
公开(公告)日：2006-10-24
申请号：US10727877
申请日：2003-12-03
申请人： James L. Winkler , Mark Chee , David Lockhart
发明人： James L. Winkler , Mark Chee , David Lockhart
IPC分类号： B01F11/00
CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809
摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.
摘要翻译： 本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。 一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。 该装置包括具有旋转轴线的可转动体。 可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。
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公开(公告)号：US06849462B1
公开(公告)日：2005-02-01
申请号：US09579991
申请日：2000-05-26
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/2575
摘要： A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.
摘要翻译： 一种通过在衬底上沉积抗蚀剂来制造阵列的方法，选择性地去除抗蚀剂的一部分以暴露局部区域，分配单体以占据支撑体表面小于1cm 2的局部区域，从而允许 单体直接或间接地结合到载体上并重复步骤以形成至少10种不同聚合物的阵列。
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公开(公告)号：US06551817B2
公开(公告)日：2003-04-22
申请号：US10046623
申请日：2002-01-14
IPC分类号： C12M134
CPC分类号： B01L3/502715 , B01F13/0054 , B01F13/0059 , B01F13/02 , B01F13/08 , B01F13/0818 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00371 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502707 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , B01L2300/0877 , B01L2300/1805 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0611 , B01L2400/065 , B82Y30/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , G01N2035/00158 , H01L21/67144 , Y10T436/25
摘要： A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
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