摘要:
Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要:
Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.
摘要:
Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.
摘要:
The present invention relates to a functionally integrated microanalytical system for performing fluorescence spectroscopy. A source of fluorescence-exciting radiation, typically a LED, is integrated onto a substrate along with a photodetector and, in some embodiments, an optical filter. A pixel-to-point laser lift-off process is used to effect this component integration. For those cases in which a filter is required, a thin film bandgap filter is typically used, such as CdS or CdSxSe1-x (0
摘要:
Disclosed herein is an innovative plasmonic droplet including a droplet of fluid, a detection-target material which is in the droplet of fluid, and a nanoplasmon probe which is on a surface of the droplet of fluid and/or in the droplet of fluid. The plasmonic droplet may be applied for plasmon based optical sensing techniques, for example, for ultrasensitive analysis of bacteria, pathogen, etc.
摘要:
Disclosed is an innovative method for detecting metal ions based on selective plasmonic resonance energy transfer between metal-ligand complexes and a single nanoplasmonic particle as a probe. The selective plasmonic resonance energy transfer occurs if a resonance frequency matching condition between the single nanoplasmonic particle and the metal-ligand complexes is satisfied.
摘要:
Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
摘要:
Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
摘要:
This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity. The probe enables detection of proteolytic activity in extremely small volume and at low concentration. In certain embodiments the probes comprise an indicator for the detection of an active protease, where the indicator comprises a nanocrescent attached to a peptide, where said peptide comprises a recognition site for the protease and a Raman tag attached to the peptide.
摘要:
Methods for detection of molecular recognition and analysis of cells are provided. Both optical and non-optical methods are presented. Methods utilize capture of particles in semi-permeable structures. Specific microfluidic system architectures for conducting biomolecule and cell assays are described.