公开(公告)号：US20150164386A1

公开(公告)日：2015-06-18

申请号：US14466138

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  MICHAEL E. MILLER ,  NING YANG

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/053 ,  A61B5/1486

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20220189631A1

公开(公告)日：2022-06-16

申请号：US17163186

申请日：2021-01-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ELAINE GEE ,  JEFFREY NISHIDA ,  PETER AJEMBA ,  KEITH NOGUEIRA ,  ANDREA VARSAVSKY

IPC: G16H50/20 ,  G06N20/00 ,  G16H40/63

Abstract: Methods, systems, and devices for improving continuous glucose monitoring (“CGM”) are described herein. More particularly, the methods, systems, and devices describe retrieving a machine learning model that is trained to classify CGM sensor data and blanking the CGM sensor data based on an outlier classification from the machine learning model. The system may terminate sensors for which there is an aggregation of blanked CGM sensor data. The methods, systems, and devices described herein may additionally comprise a machine learning model that is trained to detect and correct for erroneous sensor use conditions based on error patterns in sensor data. The system may determine resolutions for correcting the detected erroneous sensor use conditions.

公开(公告)号：US20210161439A1

公开(公告)日：2021-06-03

申请号：US17175146

申请日：2021-02-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  XIAOLONG LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170150911A1

公开(公告)日：2017-06-01

申请号：US15428589

申请日：2017-02-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  Xiaolong LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1468 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20220189630A1

公开(公告)日：2022-06-16

申请号：US17121624

申请日：2020-12-14

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ELAINE GEE ,  JEFFREY NISHIDA ,  PETER AJEMBA ,  KEITH NOGUEIRA ,  ANDREA VARSAVSKY

IPC: G16H50/20 ,  G06N20/00 ,  G16H40/63

Abstract: Methods, systems, and devices for improving continuous glucose monitoring (“CGM”) are described herein. More particularly, the methods, systems, and devices describe retrieving a machine learning model that is trained to classify CGM sensor data and blanking the CGM sensor data based on an outlier classification from the machine learning model. The system may terminate sensors for which there is an aggregation of blanked CGM sensor data. The methods, systems, and devices described herein may additionally comprise a machine learning model that is trained to detect and correct for erroneous sensor use conditions based on error patterns in sensor data. The system may determine resolutions for correcting the detected erroneous sensor use conditions.

公开(公告)号：US20150164387A1

公开(公告)日：2015-06-18

申请号：US14466177

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  MICHAEL E. MILLER ,  BRADLEY C. LIANG

IPC: A61B5/1495 ,  G01N27/02 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20150164371A1

公开(公告)日：2015-06-18

申请号：US14466160

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  NING YANG

IPC: A61B5/053 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20210113111A1

公开(公告)日：2021-04-22

申请号：US17115752

申请日：2020-12-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  NING YANG

IPC: A61B5/0537 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61M5/158 ,  A61B5/0538 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/02

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20190175082A1

公开(公告)日：2019-06-13

申请号：US15840785

申请日：2017-12-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  Michael E. Miller

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495

Abstract: A pseudo-orthogonally redundant glucose sensor device may include one or more electrochemical peroxide-based glucose sensor(s) and one or more electrochemical oxygen-based sensor(s). The electrochemical peroxide-based glucose sensor(s) may operate as traditional peroxide-based sensor(s), which may include a chemistry stack with glucose oxidase as a catalytic agent. The electrochemical oxygen-based sensor(s) may be used to measure oxygen, as well as to measure glucose by computing differences in oxygen between two working electrodes. In embodiments of the invention, one of the oxygen-based sensors may be used directly as a diagnostic to determine whether each peroxide-based glucose sensor is functioning properly, as well as to determine which modality of sensing to use. Because of the internal oxygen-based reference, the glucose sensor device provides oxygen-resistant glucose sensing, as well as near-orthogonal redundancy.

公开(公告)号：US20190041345A1

公开(公告)日：2019-02-07

申请号：US16158043

申请日：2018-10-11

Applicant: MEDTRONIC MINIMED, INC.

Inventor： KEITH NOGUEIRA ,  TALY G. ENGEL ,  XIAOLONG LI ,  BRADLEY C. LIANG ,  RAJIV SHAH ,  JAEHO KIM ,  MIKE C. LIU ,  ANDY Y. TSAI ,  ANDREA VARSAVSKY ,  FEI YU

IPC: G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/487

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.