公开(公告)号：US20210113119A1

公开(公告)日：2021-04-22

申请号：US17135766

申请日：2020-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： NING YANG ,  RAGHAVENDHAR GAUTHAM ,  RAJIV SHAH

IPC: A61B5/1495 ,  G01N27/416 ,  A61B5/00 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61B5/1459 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/0537 ,  G01N33/66 ,  A61M5/172 ,  G01N27/02 ,  A61B5/0538 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20210113111A1

公开(公告)日：2021-04-22

申请号：US17115752

申请日：2020-12-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  NING YANG

IPC: A61B5/0537 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61M5/158 ,  A61B5/0538 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/02

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20170209082A1

公开(公告)日：2017-07-27

申请号：US15483404

申请日：2017-04-10

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  XIAOLONG LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  C12Q1/00 ,  A61M5/172 ,  G01N21/59 ,  G01N27/416 ,  G01N27/327 ,  A61B5/1495 ,  A61M5/142

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150164382A1

公开(公告)日：2015-06-18

申请号：US14466126

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  MICHAEL E. MILLER ,  BRADLEY C. LIANG ,  NING YANG

IPC: A61B5/1473 ,  A61B5/1495 ,  A61B5/053 ,  A61B5/145

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20170172474A1

公开(公告)日：2017-06-22

申请号：US15446886

申请日：2017-03-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： NING YANG ,  Raghavendhar Gautham ,  Bradley C. Liang ,  Rajiv Shah

IPC: A61B5/145 ,  G01N27/02 ,  A61B5/053 ,  G01N33/49 ,  A61B5/1495 ,  A61B5/00 ,  G01N33/66 ,  G01N27/416 ,  A61B5/1486

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20150164371A1

公开(公告)日：2015-06-18

申请号：US14466160

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  NING YANG

IPC: A61B5/053 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20170164879A1

公开(公告)日：2017-06-15

申请号：US15444940

申请日：2017-02-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： NING YANG ,  RAGHAVENDHAR GAUTHAM ,  BRADLEY C. LIANG ,  RAJIV SHAH

IPC: A61B5/145 ,  G01N33/66 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1495 ,  G01N27/416 ,  A61B5/053

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US20150164386A1

公开(公告)日：2015-06-18

申请号：US14466138

申请日：2014-08-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  FEI YU ,  MICHAEL E. MILLER ,  NING YANG

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/053 ,  A61B5/1486

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6849 ,  A61B5/7221 ,  A61B5/7246 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M2005/1726 ,  G01N27/026

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

Abstract translation: 电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。 定义了等效电路模型，电路元件用于表征传感器行为。

公开(公告)号：US20210161439A1

公开(公告)日：2021-06-03

申请号：US17175146

申请日：2021-02-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  XIAOLONG LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170176381A1

公开(公告)日：2017-06-22

申请号：US15453119

申请日：2017-03-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： NING YANG ,  RAJIV SHAH

IPC: G01N27/416 ,  G01N33/66 ,  A61B5/00 ,  A61B5/145 ,  A61B5/053 ,  A61B5/1495 ,  G01N27/02 ,  G01N33/96

CPC classification number: G01N27/4163 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/7242 ,  A61B5/746 ,  A61B2562/0214 ,  A61B2562/04 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1726 ,  G01N27/026 ,  G01N27/028 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96 ,  G01R35/00 ,  G01R35/005

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.