公开(公告)号：US20240018571A1

公开(公告)日：2024-01-18

申请号：US17999076

申请日：2021-05-18

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John KENTEN ,  Jacob N. WOHLSTADTER

IPC: C12Q1/6818

CPC classification number: C12Q1/6818

Abstract: The invention relates to methods, oligonucleotide reagents, compositions, and kits for nucleic acid detection.

公开(公告)号：US20220365106A1

公开(公告)日：2022-11-17

申请号：US17679663

申请日：2022-02-24

Applicant: Meso Scale Technologies, LLC.

Inventor： Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Don E. KRUEGER ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Jacob N. WOHLSTADTER ,  Michael L. VOCK ,  Stanley T. SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/08 ,  G06Q10/10

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20220381780A1

公开(公告)日：2022-12-01

申请号：US17749721

申请日：2022-05-20

Applicant: Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  James WILBUR ,  Jeffery DEBAD ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Christopher CAMPBELL ,  Anastasia AKSYUK ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA ,  Chien Li LIN

IPC: G01N33/569 ,  G01N33/543 ,  G01N33/58

Abstract: The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention further provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

公开(公告)号：US20210407692A1

公开(公告)日：2021-12-30

申请号：US17359479

申请日：2021-06-25

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. WOHLSTADTER ,  Michael VOCK ,  Charles M. CLINTON ,  George SIGAL

IPC: G16H50/80 ,  G16H40/67 ,  G16H10/40 ,  G16H40/20 ,  G06Q50/30 ,  G16H50/20 ,  G01N21/76

Abstract: Provided herein are systems, methods, and apparatuses for providing a real-time global bio-surveillance and response solution. The systems and apparatuses may include one or more sentinel subsystems and one or more surge subsystems that each include a real-time, cloud-based, distributed, interconnected set of hardware, software, and/or firmware for comprehensive surveillance, complete detection, and immediate response various to biological, chemical, and/or bio-chemical anomalies, for example, a new or emerging pathogen or other health condition.

公开(公告)号：US20210389338A1

公开(公告)日：2021-12-16

申请号：US17412688

申请日：2021-08-26

Applicant: Meso Scale Technologies, LLC.

Inventor： Manish KOCHAR ,  Peter J. BOSCO ,  Ian D. CHAMBERLIN ,  Bandele JEFFREY-COKER ,  Eric M. JONES ,  Gary I. KRIVOY ,  Aaron H. LEIMKUEHLER ,  Pei-Ming WU ,  Kim-Xuan NGUYEN ,  Pankaj OBEROI ,  Louis W. PANG ,  Jennifer PARKER ,  Victor PELLICIER ,  Nicholas SAMMONS ,  George SIGAL ,  Jacob N. WOHLSTADTER ,  Michael L. VOCK ,  Stanley T. SMITH ,  Carl C. STEVENS ,  Rodger D. OSBORNE ,  Kenneth E. PAGE ,  Michael T. WADE ,  Jon WILLOUGHBY ,  Lei WANG ,  Don E. KRUEGER

IPC: G01N35/00 ,  B01L3/00 ,  B01L9/00 ,  G16H40/67 ,  G16H10/40 ,  G16H40/40 ,  F24F11/30 ,  G06K7/14 ,  G06Q10/08 ,  G06Q10/10

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

公开(公告)号：US20240287572A1

公开(公告)日：2024-08-29

申请号：US18555331

申请日：2022-04-15

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： John H. KENTEN ,  Jacob N. WOHLSTADTER

IPC: C12Q1/34 ,  C12Q1/682

CPC classification number: C12Q1/34 ,  C12Q1/682

Abstract: The invention relates to methods, compositions, and kits for detection of hydrolase enzyme activity in a sample.

公开(公告)号：US20240272116A1

公开(公告)日：2024-08-15

申请号：US18441769

申请日：2024-02-14

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Manish KOCHAR ,  Mark BILLADEAU ,  Charles M. CLINTON ,  Scott DOWDELL ,  Aaron H. LEIMKUEHLER ,  Alexander K. TUCKER-SCHWARTZ ,  Jules VANDERSARL ,  Jon WILLOUGHBY ,  Jacob N. WOHLSTADTER

IPC: G01N27/417 ,  G01N27/30 ,  G01N27/327

CPC classification number: G01N27/417 ,  G01N27/301 ,  G01N27/305 ,  G01N27/308 ,  G01N27/3277

Abstract: Electrochemical cells and methods for their production are provided. In particular, multi-well assay plates including multi-electrode wells are provided. The multi-electrode wells contain multiple electrodes that are electrically isolated from one another, permitting the various electrodes of the various wells to be addressed in any suitable combination.

公开(公告)号：US20240264085A1

公开(公告)日：2024-08-08

申请号：US18617770

申请日：2024-03-27

Applicant: Meso Scale Technologies, LLC.

Inventor： Charles M. CLINTON ,  Jacob N. WOHLSTADTER

IPC: G01N21/76 ,  B01L3/00 ,  G01N21/64 ,  G01N33/543

CPC classification number: G01N21/76 ,  B01L3/502 ,  G01N21/6452 ,  G01N33/54366 ,  B01L2200/025 ,  B01L2200/18 ,  B01L2300/021 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/0867 ,  G01N2201/068 ,  G01N2201/12

Abstract: We describe a detection module useful with an apparatus and/or system for conducting luminescence assays, and a kit, a system, an apparatus, and a method incorporating the detection module.

公开(公告)号：US20230184768A1

公开(公告)日：2023-06-15

申请号：US17997267

申请日：2021-04-30

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56983 ,  G01N33/6854 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2469/20

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20160370359A1

公开(公告)日：2016-12-22

申请号：US15256364

申请日：2016-09-02

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： George B. SIGAL ,  Jacob N. WOHLSTADTER ,  Satyanarayana GUDIBANDE ,  Mark T. MARTIN ,  James L. WILBUR

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/552

CPC classification number: G01N33/54346 ,  B82Y30/00 ,  C07B2200/11 ,  C07H21/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/532 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/5438 ,  G01N33/552 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2458/30 ,  C12Q2563/149 ,  C12Q2563/113 ,  C12Q2537/125

Abstract: A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.

Abstract translation: 提出了一种用于进行电化学发光测定的方法和装置。 在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。 在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及 （c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。