公开(公告)号：US09215985B2

公开(公告)日：2015-12-22

申请号：US14111248

申请日：2012-04-10

申请人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

发明人： Malte Gross ,  Pascal Kopperschmidt ,  Andreas Maierhofer ,  Alfred Gagel

IPC分类号： G01N21/00 ,  A61B5/00 ,  A61M1/36 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/64 ,  G01N21/65

CPC分类号： A61B5/0082 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/14557 ,  A61M1/367 ,  G01N21/6486 ,  G01N21/65

摘要： A method of monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis, that includes the steps of irradiating a sample of a dialysis liquid used in the treatment with irradiation light of at least a first irradiation wavelength, detecting light emitted by the irradiated sample in at least a first detection wavelength, the detection wavelength being different from the first irradiation wavelength, and determining the presence and/or concentration of at least one analyte in the sample on the basis of the detected light.

摘要翻译： 一种监测患者治疗的方法，优选用于监测血液透析，血液透析滤过和/或腹膜透析，其包括以下步骤：用至少第一照射波长的照射光照射用于治疗的透析液样品，检测 由至少第一检测波长的被照射样品发射的光，检测波长不同于第一照射波长，并且基于检测到的光来确定样品中至少一种分析物的存在和/或浓度。

公开(公告)号：US08465641B2

公开(公告)日：2013-06-18

申请号：US12452956

申请日：2008-07-30

申请人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

发明人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

IPC分类号： B01D61/30

CPC分类号： A61M1/1656 ,  A61M2205/15

摘要： A dialysis liquid circuit with conduits for conducting dialysis liquid and elements for detecting air in the dialysis liquid. The elements includes at least one gas sensor traversed continuously by the dialysis liquid, which is configured such that it measures at least one property of the dialysis liquid which depends on the presence of air bubbles in the dialysis liquid, and which is arranged downstream of a region to be monitored of the dialysis liquid circuit. During operation of the dialysis liquid circuit a negative pressure exists with respect to atmospheric pressure, and the elements includes an evaluation unit which is connected with the gas sensor and which is configured such that the property measured by means of the gas sensor is evaluated with regard to the presence of air bubbles in the dialysis liquid.

摘要翻译： 透析液回路，其具有用于透析液体的导管和用于检测透析液中的空气的元件。 这些元件包括由透析液连续穿过的至少一个气体传感器，其被配置为使得其测量透析液体的至少一个性质，其依赖于透析液体中的气泡的存在，并且其布置在 要监测透析液回路的区域。 在透析液体回路的运转中，相对于大气压存在负压，并且元件包括与气体传感器连接的评估单元，其被构造为使得通过气体传感器测量的性质被评估 到透析液体中存在气泡。

公开(公告)号：US20100133189A1

公开(公告)日：2010-06-03

申请号：US12452956

申请日：2008-07-30

申请人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

发明人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross

IPC分类号： B01D61/30 ,  G01N33/49 ,  G01N7/00

CPC分类号： A61M1/1656 ,  A61M2205/15

摘要： The present invention relates to a dialysis liquid circuit with conduits for conducting dialysis liquid and with means for detecting air in the dialysis liquid, wherein the means comprise at least one gas sensor traversed continuously by the dialysis liquid, which is configured such that it measures at least one property of the dialysis liquid which depends on the presence of air bubbles in the dialysis liquid, and which is arranged downstream of a region to be monitored of the dialysis liquid circuit, in which during operation of the dialysis liquid circuit a negative pressure exists with respect to atmospheric pressure, wherein the means comprise an evaluation unit which is connected with the gas sensor and which is configured such that the property measured by means of the gas sensor is evaluated with regard to the presence of air bubbles in the dialysis liquid.

摘要翻译： 本发明涉及一种透析液体回路，其具有用于进行透析液体的管道和用于检测透析液体中的空气的装置，其中该装置包括由透析液连续穿过的至少一个气体传感器，其被配置为使其在 所述透析液的至少一种性质取决于透析液体中气泡的存在，并且其布置在透析液体回路的监测区域的下游，其中在透析液体回路的操作期间存在负压 相对于大气压力，其中所述装置包括评估单元，其与所述气体传感器连接，并且被配置为使得通过所述气体传感器测量的性质关于所述透析液体中的气泡的存在被评估。

公开(公告)号：US20090321360A1

公开(公告)日：2009-12-31

申请号：US12448979

申请日：2008-01-17

申请人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross ,  Michael Koch

发明人： Andreas Maierhofer ,  Alfred Gagel ,  Malte Gross ,  Michael Koch

IPC分类号： B01D61/34

CPC分类号： A61M1/1605 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  A61M1/169 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/702 ,  A61M2205/707 ,  A61M2205/7554

摘要： The present invention relates to a dialysis machine comprising at least one filter for the filtration of the dialysis liquid and comprising means for determining the calcification of the dialysis machine, wherein the means for the determining of the calcification of the dialysis machine comprising one or more sensors, with the sensor or sensors being configured and arranged such that the ion concentration or a parameter representative of the ion concentration or of its change of the dialysis liquid, of a solution serving the decalcification or of another measuring solution can be detected by these either downstream or upstream and downstream of the at least one filter, and wherein the means for determining the calcification of the dialysis machine furthermore have an evaluation or calculation unit which is configured such that it determines the calcification of the dialysis machine on the basis of the ion concentration or parameter value detected by means of the sensor or sensors. The invention further relates to a method of determining the calcification of a dialysis machine.

摘要翻译： 本发明涉及一种透析机，其包括至少一个用于过滤透析液体的过滤器，并且包括用于确定透析机的钙化的装置，其中用于确定透析机钙化的装置包括一个或多个传感器 传感器或传感器被配置和布置成使得代表脱钙液的溶液的离子浓度或其变化的离子浓度或参数，或者用于脱钙的溶液或另一种测量溶液的离子浓度或参数可以由下游 或至少一个过滤器的上游和下游，并且其中用于确定透析机钙化的装置还具有评估或计算单元，其被配置为使得其基于离子浓度确定透析机的钙化 或通过传感器或传感器检测的参数值。 本发明还涉及一种确定透析机钙化的方法。

公开(公告)号：US08764987B2

公开(公告)日：2014-07-01

申请号：US13262407

申请日：2010-03-31

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： B01D61/32 ,  B01D61/24 ,  B01D61/26 ,  B01D61/28 ,  A61M1/14

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65

摘要： An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.

摘要翻译： 一种用于确定和调节流体回路中至少一种溶解物质的浓度的装置和方法，其中，所述流体回路包括以半渗透方式由过滤器隔开的至少两个部分回路，包括检测单元 用于确定至少一种第一溶解物质的浓度差的确定单元，用于确定与所述至少一种第一溶解物质不同的至少一种第二溶解物质的影​​响的判定单元，以及用于调节所述至少一种溶解物质浓度的调节单元 至少一种溶解物质在流体回路中。

公开(公告)号：US08784353B2

公开(公告)日：2014-07-22

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M37/00 ,  A61M39/00 ,  A61M39/10 ,  A61M39/22 ,  A61M1/36

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US20110196279A1

公开(公告)日：2011-08-11

申请号：US13123290

申请日：2009-10-02

申请人： Andreas Maierhofer ,  Malte Gross

发明人： Andreas Maierhofer ,  Malte Gross

IPC分类号： A61M1/14

CPC分类号： A61M1/367 ,  A61M1/3656 ,  A61M1/3663 ,  A61M39/10 ,  A61M39/105 ,  A61M39/1055 ,  A61M39/22 ,  A61M39/223 ,  A61M2039/1044 ,  A61M2039/229 ,  A61M2205/3515 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/6018 ,  A61M2205/6054 ,  F16K11/074

摘要： A device for reversing the blood flow for an extracorporeal blood treatment device, which has an extracorporeal blood circuit, includes an arterial blood line leading from a patient to a blood treatment unit and a venous blood line leading from the blood treatment unit to the patient. Furthermore, an extracorporeal blood treatment device includes a device for reversing the blood flow, and a method includes determining the reversal of the blood flow during an extracorporeal blood treatment. The device for reversing the blood flow for an extracorporeal blood treatment device includes two valve bodies which are rotated relative to one another for reversing the blood flow. The device for reversing the blood flow includes a communication device for receiving an electromagnetic high-frequency field from a read unit of the extracorporeal blood treatment device and for generating at least one identifier characterizing the position of the valve bodies which can be read by the read device.

摘要翻译： 具有体外血液回路的体外血液处理装置的血流的逆转装置，包括从病人通向血液处理单元的动脉血线和从血液处理单元导入患者的静脉血液管路。 此外，体外血液处理装置包括用于逆转血流的装置，并且包括确定在体外血液处理期间血液流动的逆转的方法。 用于反转体外血液处理装置的血流的装置包括相对于彼此旋转以逆转血流的两个阀体。 用于反转血流的装置包括用于从体外血液处理装置的读取单元接收电磁高频场的通信装置，并且用于产生表征可被读取的阀体读取的阀体的位置的至少一个标识符 设备。

公开(公告)号：US06939471B2

公开(公告)日：2005-09-06

申请号：US10393361

申请日：2003-03-21

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： A61M1/16 ,  B01D61/32 ,  A61M1/14 ,  B01D61/24 ,  B01D61/28

CPC分类号： A61M1/16 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/1654 ,  A61M1/1656 ,  A61M1/361 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/52

摘要： A method for determining a treatment parameter on a haemofiltration device, as well as a haemofiltration device for applying the method, based on the recognition that a determination method known from haemodialysis can, with little modification, be transferred to haemofiltration. To this effect a physical-chemical characteristic of the substitution fluid and of the fluid which is removed from the haemofilter by way of an ultrafiltrate outlet pipe, is determined. Furthermore, this characteristic is acquired before, after or during a change of this characteristic in the substitution fluid, and is evaluated. As a result, the ion dialysance and thus the urea clearance of a haemofiltration device, which can also be operated as a haemodiafiltration device, can be determined.

摘要翻译： 基于认识到从血液透析已知的测定方法可以很少改进的方法转移到血液过滤中，用于确定血液净化装置上的治疗参数以及用于应用该方法的血液净化装置的方法。 为此，确定了取代流体和通过超滤出口管从除污机除去的流体的物理化学特性。 此外，在替代液中的该特性的变化之前，之后或期间获取该特性，并进行评价。 结果，可以确定也可以作为血液透析过滤装置操作的血液净化装置的离子透析性以及因此的尿素清除率。

公开(公告)号：US20120018379A1

公开(公告)日：2012-01-26

申请号：US13262407

申请日：2010-03-31

申请人： Malte Gross ,  Andreas Maierhofer

发明人： Malte Gross ,  Andreas Maierhofer

IPC分类号： B01D61/32 ,  B01D61/24

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65

摘要： The present invention relates to an apparatus and to a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, wherein the fluid circuit comprises at least two partial circuits, and wherein the partial circuits are separated by filter in a semi-permeable manner.

摘要翻译： 本发明涉及一种用于确定和调节流体回路中至少一种溶解物质的浓度的装置和方法，其中流体回路包括至少两个部分回路，并且其中部分回路由过滤器分离 以半渗透的方式。

公开(公告)号：US08856862B2

公开(公告)日：2014-10-07

申请号：US12280887

申请日：2006-11-01

申请人： Theo Dimitrakos ,  Leonid Titkov ,  Andreas Maierhofer

发明人： Theo Dimitrakos ,  Leonid Titkov ,  Andreas Maierhofer

IPC分类号： H04L29/06 ,  G06F11/07 ,  G06F9/54 ,  H04L12/751 ,  G06F11/14

CPC分类号： G06F9/546 ,  G06F11/0715 ,  G06F11/1482 ,  H04L45/02

摘要： Methods and apparatus for controlling the operation of a distributed application using message interception techniques are disclosed. The message interception software is independent of the software components making up the distributed application. The message interception software processes messages by carrying out a series of actions set out in an interceptor chain configuration policy, that policy being selected on the basis of the contents of the intercepted message. The interceptor chain configuration policy is divided into a separate enforcement configuration policy which dictates what actions should be carried out on a message and in what order, and an interceptor reference policy which indicates references to interceptors which are suitable for carrying out the actions specified in the enforcement configuration policy. In this way, the behavior of the message interception software (and thus the distributed application) can be updated while both the interception software and the distributed application are running without requiring the person updating the behavior of the message interception software to deal with esoteric references to interceptor software routines.

摘要翻译： 公开了使用消息拦截技术来控制分布式应用的操作的方法和装置。 消息拦截软件独立于组成分布式应用程序的软件组件。 消息拦截软件通过执行在拦截器链配置策略中设置的一系列动作来处理消息，该策略是基于被拦截的消息的内容来选择的。 拦截器链配置策略被分成一个单独的强制配置策略，其规定应该对消息执行哪些动作以及以什么顺序执行，以及拦截器引用策略，其指示对拦截器的引用，该拦截器适用于执行在 执行配置策略。 以这种方式，可以在拦截软件和分布式应用程序正在运行的同时更新消息拦截软件（以及分布式应用程序）的行为，而不需要更新消息拦截软件的行为的人来处理深奥的引用 拦截器软件程序。