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1.发明申请Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of Notch gene 有权通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法公开(公告)号：US20100144034A1
公开(公告)日：2010-06-10
申请号：US12658104
申请日：2010-02-02
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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2.发明申请Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene 有权通过引入缺口基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法公开(公告)号：US20060166362A1
公开(公告)日：2006-07-27
申请号：US10503816
申请日：2003-02-06
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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3.发明授权Neural precursor cells produced from bone marrow stromal cells containing an exogenous nucleic acid encoding a notch intracellular domain (NICD) 有权由含有编码缺口胞内域（NICD）的外源核酸的骨髓基质细胞产生的神经前体细胞公开(公告)号：US08969078B2
公开(公告)日：2015-03-03
申请号：US13233701
申请日：2011-09-15
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
IPC分类号： C12N5/02 , C12N5/07 , C12N5/10 , C12N5/071 , A61K35/28 , C12N5/0793 , C12N5/077 , A61K9/00 , C12N5/079 , A61K35/12 , C12N5/0775
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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公开(公告)号：US20120009160A1
公开(公告)日：2012-01-12
申请号：US13233701
申请日：2011-09-15
申请人： Mari DEZAWA , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari DEZAWA , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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5.发明授权Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene 有权通过引入缺口基因将骨髓基质细胞分化为神经细胞或骨骼肌细胞公开(公告)号：US07682825B2
公开(公告)日：2010-03-23
申请号：US10503816
申请日：2003-02-06
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
IPC分类号： C12N15/00
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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6.发明授权Method of inducing differentiation of bone marrow stromal cells to neural precursor cells, neural precursor cells, and uses thereof 有权诱导骨髓基质细胞分化为神经前体细胞，神经前体细胞的方法及其用途公开(公告)号：US08361456B2
公开(公告)日：2013-01-29
申请号：US12584657
申请日：2009-09-10
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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7.发明授权Bone marrow stromal cells comprising a nucleic acid encoding a notch intracellular domain 有权骨髓基质细胞包含编码缺口细胞内结构域的核酸公开(公告)号：US08133725B2
公开(公告)日：2012-03-13
申请号：US12658104
申请日：2010-02-02
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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8.发明申请Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene 有权通过引入缺口基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法公开(公告)号：US20100310523A1
公开(公告)日：2010-12-09
申请号：US12584657
申请日：2009-09-10
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。
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公开(公告)号：US09099180B2
公开(公告)日：2015-08-04
申请号：US13599301
申请日：2012-08-30
申请人： Yoichi Minemura , Takayuki Tsukamoto , Takafumi Shimotori , Hiroshi Kanno , Tomonori Kurosawa , Mizuki Kaneko
发明人： Yoichi Minemura , Takayuki Tsukamoto , Takafumi Shimotori , Hiroshi Kanno , Tomonori Kurosawa , Mizuki Kaneko
CPC分类号： G11C13/0069 , G11C13/0097 , G11C2213/71 , G11C2213/72
摘要： According to one embodiment, a semiconductor memory device includes a plurality of cell array blocks and a control circuit. The control circuit sets a selected bit line to have 0 volt, applies a first electric potential which is higher than 0 volt to a selected word line, applies a second electric potential which is higher than 0 volt and lower than the first electric potential to non-selected word lines other than the selected word line, applies a third electric potential which is 0 volt or more and lower than the second electric potential to a non-selected bit line adjacent to the selected bit line in an adjacent cell array block, applies the second electric potential to non-selected bit lines other than the non-selected bit line to which the third electric potential is applied, and changes a resistance status of the resistance variable film of the selected memory cell.
摘要翻译： 根据一个实施例，半导体存储器件包括多个单元阵列块和控制电路。 控制电路将所选择的位线设置为具有0伏特，对所选择的字线施加高于0伏的第一电位，将比第一电位高于0伏且低于第一电位的第二电位施加到非 - 除了所选字线以外的选定字线，将相邻单元阵列块中与选定位线相邻的未选位线施加0伏以上且低于第2电位的第3电位， 对除了施加了第三电位的未选位线之外的非选择位线的第二电位，并且改变所选存储单元的电阻变化膜的电阻状态。
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公开(公告)号：US08970070B2
公开(公告)日：2015-03-03
申请号：US13170355
申请日：2011-06-28
申请人： Tomokazu Sada , Hiroshi Kanno
发明人： Tomokazu Sada , Hiroshi Kanno
CPC分类号： H02J50/50 , H02J5/005 , H02J7/025 , H02J50/12 , Y10T307/707 , Y10T307/729 , Y10T307/944
摘要： A wireless power transmission unit according to the present invention transmits power wirelessly from a power transmitting section 100 to a power receiving section 200 through a resonant magnetic field. The unit includes: the power transmitting section 100, which resonates at a resonant frequency f0; at least one relay section 300, which can resonate at a frequency that is selected from multiple frequencies including the resonant frequency f0; and a resonance control section 600 that outputs information that specifies a resonance condition to be imposed on the relay section 300 according to the arrangement of the power receiving section 200 and that makes the relay section 300 resonate on the resonance condition that has been specified in accordance with that information.
摘要翻译： 根据本发明的无线电力传输单元通过谐振磁场从电力发送部分100无线地发送到电力接收部分200。 该单元包括：以共振频率f0谐振的功率发送部分100; 至少一个中继部分300，其可以以从包括谐振频率f0的多个频率中选择的频率谐振; 以及谐振控制部600，其根据电力接收部200的配置输出规定要施加在中继部300上的谐振条件的信息，并使继电器部300根据已经规定的谐振条件进行谐振 与该信息。
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