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23 条记录 (耗时 0.025 秒)

    Use of materials for treatment of central nervous system lesions
    1.
    发明申请
    Use of materials for treatment of central nervous system lesions 审中-公开
    使用材料治疗中枢神经系统病变

    公开(公告)号：US20060216276A1

    公开(公告)日：2006-09-28

    申请号：US11368919

    申请日：2006-03-06

    申请人： Mari Dezawa ,  Keita Mori

    发明人： Mari Dezawa ,  Keita Mori

    IPC分类号： A61K35/30 ,  C12N5/08

    CPC分类号： A61K35/30

    摘要： Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.

    摘要翻译： 公开了用于治疗中枢神经系统病变的方法和材料。 优选的方法和材料包括神经元前体细胞和/或骨髓粘附的干细胞衍生的神经元细胞。

    Use of materials for treatment of central nervous system lesions
    2.
    发明授权
    Use of materials for treatment of central nervous system lesions 有权
    使用材料治疗中枢神经系统病变

    公开(公告)号：US08092792B2

    公开(公告)日：2012-01-10

    申请号：US12462143

    申请日：2009-07-30

    申请人： Mari Dezawa ,  Keita Mori

    发明人： Mari Dezawa ,  Keita Mori

    IPC分类号： A61K35/12

    CPC分类号： A61K35/30

    摘要： Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.

    摘要翻译： 公开了用于治疗中枢神经系统病变的方法和材料。 优选的方法和材料包括神经元前体细胞和/或骨髓粘附的干细胞衍生的神经元细胞。

    Use of materials for treatment of central nervous system lesions
    3.
    发明申请
    Use of materials for treatment of central nervous system lesions 有权
    使用材料治疗中枢神经系统病变

    公开(公告)号：US20100034790A1

    公开(公告)日：2010-02-11

    申请号：US12462143

    申请日：2009-07-30

    申请人： Mari Dezawa ,  Keita Mori

    发明人： Mari Dezawa ,  Keita Mori

    IPC分类号： A61K35/12

    CPC分类号： A61K35/30

    摘要： Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.

    摘要翻译： 公开了用于治疗中枢神经系统病变的方法和材料。 优选的方法和材料包括神经元前体细胞和/或骨髓粘附的干细胞衍生的神经元细胞。

    Method for Inducing Differentiation to Skeletal Muscle Cells
    5.
    发明申请
    Method for Inducing Differentiation to Skeletal Muscle Cells 有权
    诱导骨骼肌细胞分化的方法

    公开(公告)号：US20080113435A1

    公开(公告)日：2008-05-15

    申请号：US11722602

    申请日：2005-12-22

    申请人： Mari Dezawa ,  Yo-ichi Nabeshima ,  Mikio Hoshino

    发明人： Mari Dezawa ,  Yo-ichi Nabeshima ,  Mikio Hoshino

    IPC分类号： C12N15/09 ,  C12N5/08

    CPC分类号： C12N5/0658 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/195 ,  C12N2501/42

    摘要： A method of efficiently and conveniently inducing differentiation from bone marrow stromal cells to skeletal muscle cells, which comprises the steps of: (a) the step of adding one or more kinds of substances selected from the group consisting of a cyclic AMP increasing agent, a cAMP analogue, and a cell differentiation stimulating factor to a culture of bone marrow stromal cells, wherein said bone marrow stromal cells are not treated with a demethylating agent, and culturing the cells; (b) the step of introducing a Notch gene and/or a Notch signaling related gene into the cells obtained in the step (a), and culturing the cells to obtain a culture of myoblasts, provided that said culture does not contain the cells introduced with the gene and non-introduced cells; and (c) the step of adding a Notch ligand to the culture of myoblasts obtained in the step (b), and culturing the cells.

    摘要翻译： 一种有效且方便地诱导从骨髓基质细胞分化为骨骼肌细胞的方法，包括以下步骤：（a）添加一种或多种选自下列的物质的步骤：环AMP增加剂， cAMP类似物和对骨髓基质细胞培养物的细胞分化刺激因子，其中所述骨髓基质细胞不用去甲基化剂处理，并培养细胞; （b）将Notch基因和/或Notch信号传导相关基因导入到步骤（a）中获得的细胞中的步骤，并培养细胞以获得成肌细胞培养物，条件是所述培养物不含引入的细胞 与基因和未引入的细胞; 和（c）向步骤（b）中获得的成肌细胞培养物中加入Notch配体并培养细胞的步骤。

    Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of Notch gene
    9.
    发明申请
    Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of Notch gene 有权
    通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法

    公开(公告)号：US20100144034A1

    公开(公告)日：2010-06-10

    申请号：US12658104

    申请日：2010-02-02

    申请人： Mari Dezawa ,  Hajime Sawada ,  Hiroshi Kanno ,  Masahiko Takano

    发明人： Mari Dezawa ,  Hajime Sawada ,  Hiroshi Kanno ,  Masahiko Takano

    IPC分类号： C12N5/071 ,  C12N5/00

    CPC分类号： C12N5/0619 ,  A61K9/0085 ,  A61K35/28 ,  A61K35/30 ,  A61K2035/124 ,  C12N5/0618 ,  C12N5/0658 ,  C12N5/0663 ,  C12N2501/42 ,  C12N2502/1358 ,  C12N2506/1353 ,  C12N2510/00

    摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.

    摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。

    Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
    10.
    发明申请
    Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene 有权
    通过引入缺口基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法

    公开(公告)号：US20060166362A1

    公开(公告)日：2006-07-27

    申请号：US10503816

    申请日：2003-02-06

    申请人： Mari Dezawa ,  Hajime Sawada ,  Hiroshi Kanno ,  Masahiko Takano

    发明人： Mari Dezawa ,  Hajime Sawada ,  Hiroshi Kanno ,  Masahiko Takano

    IPC分类号： C12N5/08 ,  C12N15/87

    CPC分类号： C12N5/0619 ,  A61K9/0085 ,  A61K35/28 ,  A61K35/30 ,  A61K2035/124 ,  C12N5/0618 ,  C12N5/0658 ,  C12N5/0663 ,  C12N2501/42 ,  C12N2502/1358 ,  C12N2506/1353 ,  C12N2510/00

    摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.

    摘要翻译： 提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。 具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞 是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。 本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。 本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。