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公开(公告)号：US07109238B2
公开(公告)日：2006-09-19
申请号：US10761986
申请日：2004-01-21
申请人： Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
发明人： Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
IPC分类号： A61K31/335 , A61K31/195 , C07C303/08 , C07C63/04 , C07D255/03
CPC分类号： C07D303/22 , C07C33/34 , C07C69/616 , C07C69/738 , C07C211/26 , C07C211/30 , C07C229/36 , C07C233/05 , C07C251/48 , C07C255/57 , C07C255/58 , C07C2602/08
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：US06294531B1
公开(公告)日：2001-09-25
申请号：US09402310
申请日：1999-10-01
申请人： Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
发明人： Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
IPC分类号： C07C25550
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了具有钙离子性质的新型芳基烷基氨基化合物
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公开(公告)号：US06395919B1
公开(公告)日：2002-05-28
申请号：US09647793
申请日：2000-10-05
申请人： Pradip Kumar Bhatnagar , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen
发明人： Pradip Kumar Bhatnagar , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen
IPC分类号： C07C25503
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
摘要： Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.
摘要翻译： 新型钙质化合物，与所述化合物相配的药物组合物及其作为钙受体拮抗剂的用途。
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公开(公告)号：US20070249702A1
公开(公告)日：2007-10-25
申请号：US11668966
申请日：2007-01-30
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A61K31/135 , A61K31/18 , A61K31/357 , A61K31/404 , A61P43/00 , C07C211/03 , C07C307/02 , C07D209/04 , C07D317/46
CPC分类号： C07D209/43 , C07B2200/07 , C07C217/60 , C07C255/46 , C07C311/29 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D317/54 , C07D317/64
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US07202261B2
公开(公告)日：2007-04-10
申请号：US10896614
申请日：2004-07-21
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A01N43/40
CPC分类号： A61K31/137 , A61K31/18 , A61K31/277
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US06818660B2
公开(公告)日：2004-11-16
申请号：US10033001
申请日：2001-10-19
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A61K31135
CPC分类号： C07C323/25 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US06521667B1
公开(公告)日：2003-02-18
申请号：US09132179
申请日：1998-08-11
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： A01N3302
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
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公开(公告)号：US06432656B1
公开(公告)日：2002-08-13
申请号：US09370097
申请日：1999-08-06
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： G01N33554
CPC分类号： A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70 , Y10S435/96 , Y10S436/811 , Y10S436/815
摘要： The present invention features calcilytic compounds. “calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US6022894A
公开(公告)日：2000-02-08
申请号：US832984
申请日：1997-04-04
申请人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
发明人： Eric G. Del Mar , Robert M. Barmore , Derek Sheehan , Bradford C. Van Wagenen , James F. Callahan , Richard M. Keenan , Nikesh R. Kotecha , Maria Amparo Lago , Linda Sue Southall , Mervyn Thompson
IPC分类号： G01N33/50 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/18 , A61K31/277 , A61K31/36 , A61K31/395 , A61K31/404 , A61P19/00 , A61P19/08 , A61P19/10 , C07C217/14 , C07C217/28 , C07C217/30 , C07C217/34 , C07C217/38 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C311/29 , C07C323/25 , C07D209/42 , C07D213/65 , C07D317/58 , C07D317/64 , C07D333/70 , G01N33/15
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07D213/65 , C07D317/58 , C07D333/70 , C07C2101/14 , C07C2103/74
摘要： The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得另外的钙化合物的技术。
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公开(公告)号：US06274737B1
公开(公告)日：2001-08-14
申请号：US09574413
申请日：2000-05-19
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07D40510
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
摘要翻译： 描述了作为内皮素受体拮抗剂的新型茚满和茚衍生物
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