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公开(公告)号：US20100036501A1
公开(公告)日：2010-02-11
申请号：US12539023
申请日：2009-08-11
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodising, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
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公开(公告)号：US08945363B2
公开(公告)日：2015-02-03
申请号：US12539028
申请日：2009-08-11
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
摘要翻译： 用于外科手术的金属植入物具有与金属基底成一体的表面层，并且其包含杀生物材料。 表面层可以通过阳极氧化从金属基底生长，并通过离子交换在其中掺入生物杀伤材料。 或者，可以通过电镀沉积该层，然后进行扩散接合，以便与金属基底成为一体。 在任一情况下，银是合适的杀生物材料; 并且杀生物材料的释放速率和数量均应低，以避免对身体细胞的毒性作用。 在形成表面层之前对表面进行电抛光也是有益的，并且这可以通过电解抛光来实现。
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公开(公告)号：US08858775B2
公开(公告)日：2014-10-14
申请号：US12680757
申请日：2008-10-03
申请人： Philip James Agg , James Timothy Shawcross , Martin Edward Lee Pickford , Andrew Derek Turner , David Richard Lewis
发明人： Philip James Agg , James Timothy Shawcross , Martin Edward Lee Pickford , Andrew Derek Turner , David Richard Lewis
IPC分类号： C25D11/26 , A61L27/02 , A61L27/54 , A61L27/50 , A61F2/30 , A61B17/064 , A61F2/32 , A61F2/28 , A61B17/68
CPC分类号： C25D11/26 , A61B17/0642 , A61B17/68 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30733 , A61F2002/30808 , A61F2002/30927 , A61F2310/00023 , A61F2310/00089 , A61F2310/00095 , A61F2310/00131 , A61F2310/00407 , A61F2310/00598 , A61F2310/00616 , A61F2310/00796 , A61L27/02 , A61L27/306 , A61L27/32 , A61L27/50 , A61L27/54 , A61L2300/104 , A61L2300/404
摘要： Metal objects are treated by anodising the metal object in contact with an acidic solution, and then subjecting the anodised metal object to a reversed voltage (compared to the anodising voltage). The thus-treated metal object is then contacted with a biocidal metal-containing solution. Biocidal metal is deposited on the surface of the metal object, resulting in improved biocidal properties.
摘要翻译： 金属物体通过阳极氧化与酸性溶液接触的金属物体进行处理，然后使阳极化金属物体经受相反的电压（与阳极氧化电压相比）。 然后将如此处理的金属物体与含杀生物金属的溶液接触。 杀生金属沉积在金属物体的表面上，从而提高了杀生物性。
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公开(公告)号：US20100032309A1
公开(公告)日：2010-02-11
申请号：US12539028
申请日：2009-08-11
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodising, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
摘要翻译： 用于外科手术的金属植入物具有与金属基底成一体的表面层，并且其包含杀生物材料。 表面层可以通过阳极氧化从金属基底生长，并且通过离子交换在其中掺入的杀生物材料生长。 或者，可以通过电镀沉积该层，然后进行扩散接合，以便与金属基底成为一体。 在任一情况下，银是合适的杀生物材料; 并且杀生物材料的释放速率和数量均应低，以避免对身体细胞的毒性作用。 在形成表面层之前对表面进行电抛光也是有益的，并且这可以通过电解抛光来实现。
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公开(公告)号：US09393349B2
公开(公告)日：2016-07-19
申请号：US12539023
申请日：2009-08-11
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
摘要翻译： 用于外科手术的金属植入物具有与金属基底成一体的表面层，并且其包含杀生物材料。 表面层可以通过阳极氧化从金属基底生长，并通过离子交换在其中引入生物杀伤材料。 或者，可以通过电镀沉积该层，然后进行扩散接合，以便与金属基底成为一体。 在任一情况下，银是合适的杀生物材料; 并且杀生物材料的释放速率和数量均应低，以避免对身体细胞的毒性作用。 在形成表面层之前对表面进行电抛光也是有益的，并且这可以通过电解抛光来实现。
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公开(公告)号：US20100136083A1
公开(公告)日：2010-06-03
申请号：US12521564
申请日：2008-01-15
申请人： Thomas Campbell Prentice , Martin Edward Lee Pickford , David Richard Lewis , Andrew Derek Turner
发明人： Thomas Campbell Prentice , Martin Edward Lee Pickford , David Richard Lewis , Andrew Derek Turner
CPC分类号： A61L27/306 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/606
摘要： An implant with a metal structure for use in a surgical procedure, in which at least part of the metal structure is coated with a biocompatible metal such as titanium by plasma spraying of the metal powder. Biocidal metal cations are then absorbed by ion exchange into the coating, so that after being implanted the biocidal ions gradually leach out into the surrounding body fluids and suppress infection. The ion exchange properties of the coating may be modified by pretreatment with dilute phosphoric acid.
摘要翻译： 一种用于外科手术的具有金属结构的植入物，其中金属结构的至少一部分通过等离子体喷涂金属粉末而被诸如钛的生物相容性金属涂覆。 然后通过离子交换将杀生物金属阳离子吸收到涂层中，使得在植入之后，杀生物离子逐渐浸出到周围的体液中并抑制感染。 可以通过用稀磷酸预处理来改变涂层的离子交换性能。
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公开(公告)号：US20090198344A1
公开(公告)日：2009-08-06
申请号：US12304441
申请日：2007-06-11
申请人： Thomas Campbell Prentice , Martin Edward Lee Pickford , David Richard Lewis , Andrew Derek Turner
发明人： Thomas Campbell Prentice , Martin Edward Lee Pickford , David Richard Lewis , Andrew Derek Turner
IPC分类号： A61F2/28
CPC分类号： A61L27/047 , A61L27/06 , A61L27/32 , A61L27/54 , A61L2300/104 , A61L2300/112 , A61L2300/606
摘要： An implant with a metal structure for use in a surgical procedure, in which at a region of the implant to be in contact with bone the metal structure is provided with a roughened surface. The roughened region is then provided with a ceramic coating comprising hydroxyapatite by a thermal spraying process. Biocidal ions of silver are absorbed into the ceramic coating, and gradually leach out into body fluids after implantation. The hydroxyapatite enhances bone regrowth into the implant, while the silver ions suppress infection.
摘要翻译： 具有用于外科手术的金属结构的植入物，其中在植入物与金属结构接触的区域处设置有粗糙表面。 然后通过热喷涂方法向粗糙化区域提供包含羟基磷灰石的陶瓷涂层。 银的杀生物离子被吸收到陶瓷涂层中，植入后逐渐浸出体液。 羟基磷灰石能增强植入物中的骨再生，而银离子抑制感染。
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公开(公告)号：US09011665B2
公开(公告)日：2015-04-21
申请号：US10591793
申请日：2005-03-03
IPC分类号： A61L27/06 , A61L27/30 , A61L27/32 , A61L27/54 , C23C28/04 , C25D11/26 , A61L27/04 , A61L27/56
CPC分类号： A61L27/32 , A61L27/047 , A61L27/06 , A61L27/306 , A61L27/54 , A61L27/56 , A61L2300/104 , A61L2300/404 , A61L2400/18 , C23C28/042 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer is grown by anodizing at a voltage between 50 and 150 V, and the biocidal material incorporated in it by ion exchange. This produces a significantly harder surface than anodizing at low voltage, and generates pits containing ion-absorbing material.
摘要翻译： 用于外科手术的金属植入物具有与金属基底一体的表面层，并且包含杀生物材料。 通过在50至150V之间的电压下阳极氧化生长表面层，并通过离子交换将其包含在其中的杀生物材料。 这在低电压下产生比阳极氧化显着更硬的表面，并且产生含有离子吸收材料的凹坑。
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公开(公告)号：US20100206733A1
公开(公告)日：2010-08-19
申请号：US12680757
申请日：2008-10-03
申请人： Philip James Agg , James Timothy Shawcross , Martin Edward Lee Pickford , Andrew Derek Turner , David Richard Lewis
发明人： Philip James Agg , James Timothy Shawcross , Martin Edward Lee Pickford , Andrew Derek Turner , David Richard Lewis
CPC分类号： C25D11/26 , A61B17/0642 , A61B17/68 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30733 , A61F2002/30808 , A61F2002/30927 , A61F2310/00023 , A61F2310/00089 , A61F2310/00095 , A61F2310/00131 , A61F2310/00407 , A61F2310/00598 , A61F2310/00616 , A61F2310/00796 , A61L27/02 , A61L27/306 , A61L27/32 , A61L27/50 , A61L27/54 , A61L2300/104 , A61L2300/404
摘要： Metal objects are treated by anodising the metal object in contact with an acidic solution, and then subjecting the anodised metal object to a reversed voltage (compared to the anodising voltage). The thus-treated metal object is then contacted with a biocidal metal-containing solution. Biocidal metal is deposited on the surface of the metal object, resulting in improved biocidal properties.
摘要翻译： 金属物体通过阳极氧化与酸性溶液接触的金属物体进行处理，然后使阳极化金属物体经受相反的电压（与阳极氧化电压相比）。 然后将如此处理的金属物体与含杀生物金属的溶液接触。 杀生金属沉积在金属物体的表面上，从而提高了杀生物性。
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公开(公告)号：US07695522B2
公开(公告)日：2010-04-13
申请号：US10501538
申请日：2003-03-25
IPC分类号： A61F2/28
CPC分类号： A61L27/54 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2002/30929 , A61F2002/30967 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/0052 , A61F2310/00592 , A61F2310/00598 , A61F2310/00796 , A61L27/04 , A61L27/306 , A61L27/32 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2430/02 , C25D11/02 , C25D11/26
摘要： A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.
摘要翻译： 用于外科手术的金属植入物具有与金属基底成一体的表面层，并且其包含杀生物材料。 表面层可以通过阳极氧化从金属基底生长，并通过离子交换在其中引入生物杀伤材料。 或者，可以通过电镀沉积该层，然后进行扩散接合，以便与金属基底成为一体。 在任一情况下，银是合适的杀生物材料; 并且杀生物材料的释放速率和数量均应低，以避免对身体细胞的毒性作用。 在形成表面层之前对表面进行电抛光也是有益的，并且这可以通过电解抛光来实现。
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