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    N-aryl piperidine compounds
    1.
    发明申请
    N-aryl piperidine compounds 审中-公开
    N-芳基哌啶化合物

    公开(公告)号：US20060035932A1

    公开(公告)日：2006-02-16

    申请号：US11138618

    申请日：2005-05-25

    申请人： Martin Murphy ,  John Schullek ,  John Ward ,  Gary Look ,  Rama Jain ,  Laurence Lee

    发明人： Martin Murphy ,  John Schullek ,  John Ward ,  Gary Look ,  Rama Jain ,  Laurence Lee

    IPC分类号： A61K31/4545 ,  C07D401/14 ,  C07D401/02

    CPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14

    摘要： The present invention provides N-aryl piperidine compounds having antiinfective activity (i.e., antibacterial, antiviral), their compositions and methods of use. The compounds of the invention prevent the entry of HIV into host cells. More particularly, the compounds are effective at in inhibiting the binding interaction of HIV glycoprotein gp120 and the cell surface receptor CD4. The compounds can be used alone or in combination with other antivirals, antiinfectives, immunomodulators, or HIV entry inhibitors. More particularly, the invention relates to the prevention and treatment of HIV infectivity and AIDS.

    摘要翻译： 本发明提供具有抗感染活性的N-芳基哌啶化合物（即抗细菌，抗病毒），其组成和使用方法。 本发明的化合物防止HIV进入宿主细胞。 更具体地，这些化合物在抑制HIV糖蛋白gp120与细胞表面受体CD4的结合相互作用方面是有效的。 化合物可以单独使用或与其它抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。 更具体地说，本发明涉及艾滋病毒感染和艾滋病的预防和治疗。

    Fiber cement saw blade
    3.
    发明申请
    Fiber cement saw blade 审中-公开
    纤维水泥锯片

    公开(公告)号：US20060112799A1

    公开(公告)日：2006-06-01

    申请号：US11000118

    申请日：2004-11-30

    申请人： Neal Hambleton ,  Martin Murphy ,  Matthew Gillanders ,  Craig McGregor

    发明人： Neal Hambleton ,  Martin Murphy ,  Matthew Gillanders ,  Craig McGregor

    IPC分类号： B23D57/00

    CPC分类号： B23D61/04 ,  B23D65/02 ,  B27B33/12 ,  Y10T83/04 ,  Y10T83/9319

    摘要： The saw blade includes a plate supporting a plurality of teeth about the periphery thereof. Each tooth consists of a cutting tip supported in a tip pocket. The tips are brazed to the tip pockets with no side clearance taper created on the tips. The side faces on the tips are parallel to each other. The tip pockets are stamped into the blade using a high volume stamping process that employs a semi-circular relief at the proximate trailing corner of the tip pocket to receive the proximate trailing corner of the cutting tip. The relief can be formed in a high volume stamping process because it eliminates the need for a sharp corner. The relief accommodates the sharp edge of the cutting tip and allows the cutting tip to be properly seated on the tip pocket for connection thereto.

    摘要翻译： 锯片包括围绕其周边支撑多个齿的板。 每个牙齿由支撑在尖端口袋中的切割尖端组成。 尖端钎焊到尖端口袋，在尖端上没有产生侧面间隙锥形。 尖端上的侧面彼此平行。 使用大体积冲压工艺将尖端口袋冲压入刀片，该冲压工艺在尖端口袋的最近后角处采用半圆形浮雕以接收切割尖端的接近后角。 浮雕可以形成在大体积的冲压过程中，因为它消除了对尖角的需要。 该凸起容纳切割尖端的锋利边缘，并且允许切割尖端适当地安置在尖端口上以与其连接。

    METERED GEL DISPENSER
    4.
    发明申请
    METERED GEL DISPENSER 审中-公开
    计量凝胶分配器

    公开(公告)号：US20100217176A1

    公开(公告)日：2010-08-26

    申请号：US12775053

    申请日：2010-05-06

    申请人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Holger Kraus ,  Peter L. Sadowski ,  Paul Greenhalgh ,  Matthew Young ,  Dominic Reber ,  Martin Murphy

    发明人： R. Dario Norberto Carrara ,  Arnaud Grenier ,  Holger Kraus ,  Peter L. Sadowski ,  Paul Greenhalgh ,  Matthew Young ,  Dominic Reber ,  Martin Murphy

    IPC分类号： A61M35/00 ,  A61N1/30

    CPC分类号： A45D40/26 ,  A45D34/04 ,  A45D40/04 ,  G01F11/025

    摘要： The invention relates to a dermal flowable-composition dispenser that includes a body for retaining a supply of the composition, an application portion having an application surface, and a conduit connecting the supply chamber with the application surface for facilitating the reproducible delivery of a predetermined dose of the composition to the application surface. The application surface includes a concave application surface and a front side having an upper rim enclosing the application surface and forming a depression that has a volume that is greater than or equal to the volume of the predetermine dose. Also, the application surface is configured and dimensioned such it can receive the patient's skin to allow for removal of the predetermined dose of the composition, and wherein the concave application surface is shaped such that the entire application surface contacts the patient's skin when the application surface is pressed thereagainst.

    摘要翻译： 本发明涉及一种真皮可流动组合物分配器，其包括用于保持组合物供应的本体，具有施用表面的施用部分和将供应室与施用表面连接的导管，以便于可再现地递送预定剂量 的组合物到应用表面。 施加表面包括凹入的施加表面和前侧，其具有封闭施加表面的上边缘并形成具有大于或等于预定剂量的体积的凹陷的凹陷。 此外，施用表面被构造和定尺寸使得其可以接收患者的皮肤以允许去除组合物的预定剂量，并且其中凹形施用表面成形为使得整个施用表面在使用表面接触患者的皮肤时 被压在那里

    Systems and methods for time corrected lightning detection
    6.
    发明申请
    Systems and methods for time corrected lightning detection 有权
    用于时间校正雷电检测的系统和方法

    公开(公告)号：US20050251711A1

    公开(公告)日：2005-11-10

    申请号：US11035018

    申请日：2005-01-12

    申请人： Martin Murphy ,  Wolfgang Schulz ,  Alburt Pifer ,  Kenneth Cummins

    发明人： Martin Murphy ,  Wolfgang Schulz ,  Alburt Pifer ,  Kenneth Cummins

    IPC分类号： G01W1/16 ,  G11B5/00 ,  G06K5/04 ,  G11B20/20

    CPC分类号： G01W1/16

    摘要： A lightning detection system provides an estimated location of a lightning stroke. The system includes sensors, and an analyzer. Each sensor provides messages having sensor identification, an amplitude responsive to the lightning stroke, and a time of detecting the lightning stroke. The analyzer applies time corrections and amplitude corrections to improve the accuracy of determining the location of the lightning stroke. Time adjustments and amplitude adjustments for the time and amplitude corrections are recalled from a matrix accessed according to a suggested or estimated location. The matrix may be organized by coordinates of longitude and latitude.

    摘要翻译： 闪电检测系统提供雷击的估计位置。 该系统包括传感器和分析仪。 每个传感器提供具有传感器识别，响应于雷击的振幅和检测雷击时间的信息。 分析仪应用时间校正和幅度校正，以提高确定雷击位置的准确性。 时间和幅度校正的时间调整和幅度调整从根据建议或估计位置访问的矩阵中调用。 矩阵可以通过经度和纬度的坐标来组织。

    SYRINGE
    10.
    发明申请
    SYRINGE 审中-公开
    注射器

    公开(公告)号：US20120226240A1

    公开(公告)日：2012-09-06

    申请号：US13510213

    申请日：2010-11-19

    申请人： Tony Bedford ,  Duncan Bishop ,  Andrew Gow ,  Dave Harris ,  Nick Hawson ,  Dominic Lloyd-Lucas ,  Martin Murphy ,  Christophe Royer

    发明人： Tony Bedford ,  Duncan Bishop ,  Andrew Gow ,  Dave Harris ,  Nick Hawson ,  Dominic Lloyd-Lucas ,  Martin Murphy ,  Christophe Royer

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31591 ,  A61M5/3158 ,  A61M2005/31508

    摘要： A syringe (2) for dispensing a fluid, the syringe including a barrel (4) including a discharge end (10) defining a discharge passage, and a plunger (15) disposed within the barrel, the plunger being adapted to move within the barrel such that the plunger and discharge end define a variable volume chamber within the barrel and the plunger is capable of displacing fluid from the chamber through the discharge passage; wherein the syringe includes a rotational element (20a, 20b, 24a, 24b) adapted to rotate about longitudinal axis of the syringe and which has a first axial orientation relative to the discharge end of the barrel and a first stop is provided on the plunger and/or the barrel which is adapted to limit axial movement of the plunger in the first orientation of the rotational element, and the rotational element has a second axial orientation relative to the discharge end of the barrel in which the first stop is disengaged and movement of the plunger is permitted to a second stop.

    摘要翻译： 一种用于分配流体的注射器（2），所述注射器包括包括限定排出通道的排出端（10）的筒（4）和设置在所述筒内的柱塞（15），所述柱塞适于在所述筒 使得柱塞和排出端在筒体内限定可变体积腔室，并且柱塞能够使来自腔室的流体通过排出通道移位; 其中所述注射器包括适于围绕所述注射器的纵向轴线旋转的旋转元件（20a，20b，24a，24b），并且所述旋转元件相对于所述镜筒的排出端具有第一轴向定位，并且在所述柱塞上设置有第一止动件， /或适于限制柱塞在旋转元件的第一方向上的轴向运动的筒体，并且旋转元件相对于筒体的排出端具有第二轴向定向，其中第一止挡件脱开，并且运动 柱塞被允许进行第二次停止。