Anti-trypanosomiasis agent
    3.
    发明授权
    Anti-trypanosomiasis agent 有权
    抗锥虫病药

    公开(公告)号:US07795285B2

    公开(公告)日:2010-09-14

    申请号:US11576426

    申请日:2005-09-29

    IPC分类号: A01N43/78

    摘要: The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).

    摘要翻译: 本发明提供具有高选择性毒性和对锥虫病的高预防或治疗作用的抗锥虫病药,其包含由以下通式(1)表示的化合物作为活性成分(其中R 1和R 2各自独立地表示 氢原子,卤素原子,羟基,氧原子,C 1-5烷基,C 1-5烷氧基,C 5-8芳基,C 5-8芳氧基,C 2-6烷氧基羰基或C 2-6烷基氨基羰基, 可以相互结合; R3,R4和R5各自独立地表示C1-5烷基或C5-8芳基; R6和R7各自独立地表示氢原子,卤素原子,羟基,氧原子,C1- 8个烷基,C 1-5烷氧基,C 5-8芳基,C 5-8芳氧基或C 2-6烷氧基羰基,并且可以彼此结合; Y和Z各自独立地表示形成 5-或6-元杂环; m和n各自表示0或1; Q表示物理 生理上可接受的阴离子 k表示0〜2的整数,使整个分子的电荷为0)。

    MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION
    4.
    发明申请
    MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION 有权
    用于预防或治疗PARASITIC PROTOZOAN感染的药物组合物

    公开(公告)号:US20100113789A1

    公开(公告)日:2010-05-06

    申请号:US11576429

    申请日:2005-09-30

    IPC分类号: C07D417/14

    摘要: The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or —NR1— (R1 represents an alkyl group, aryl group or heterocyclic group); L1, L2, L3, L4 and L5 each independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less.)

    摘要翻译: 本发明提供一种用于预防或治疗对寄生原虫感染具有高选择性毒性的寄生原虫感染的药物组合物,以及优异的预防或治疗效果。 用于预防或治疗寄生原生动物感染的药物组合物包含由以下通式(1)表示的化合物作为活性成分(其中R表示烷基,芳基或杂环基; A和B各自独立地表示5-或 含有至少一个杂原子的6元环或其中1个以上3〜8元环稠合的缩合环; Y表示S,O,Se或-NR1-(R1表示烷基,芳基 基团或杂环基); L1,L2,L3,L4和L5各自独立地表示次甲基; Q表示生理上可接受的阴离子; k表示使整个分子0的电荷所必需的0至2的整数; p和q各自表示0〜3的整数,p和q的和为1以上6以下)

    Silver halide color photographic material
    6.
    发明授权
    Silver halide color photographic material 失效
    卤化银彩色照相材料

    公开(公告)号:US5871895A

    公开(公告)日:1999-02-16

    申请号:US822686

    申请日:1997-03-24

    申请人: Kozo Sato

    发明人: Kozo Sato

    CPC分类号: G03C7/3835

    摘要: A silver halide color photographic material is disclosed which contains at least one 1H-pyrrolo�1,2-c!�1,2,3!triazole based dye-forming coupler represented by the following formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represents a hydrogen atom or a substituent; and X represents a hydrogen atom or a group capable of being released upon reaction with the oxidation product of a color developing agent.

    摘要翻译: 公开了一种卤化银彩色照相材料,其含有至少一种由下式表示的1H-吡咯并[1,2-c] [1,2,3]三唑基染料形成成色剂:其中R1,R2和 R3各自表示氢原子或取代基; X表示氢原子或能够与彩色显影剂的氧化物反应而释放的基团。

    Dye forming couplers and silver halide color photosensitive material
containing the same
    8.
    发明授权
    Dye forming couplers and silver halide color photosensitive material containing the same 失效
    染料形成成色剂和含有卤化银色光敏材料

    公开(公告)号:US5401624A

    公开(公告)日:1995-03-28

    申请号:US145630

    申请日:1993-11-04

    IPC分类号: C07D487/04 G03C7/38

    摘要: A silver halide color photosensitive material which forms a cyan dye that has superior heat resistance and that will not readily fade in a reducing atmosphere. The silver halide color photosensitive material contains in at least one layer on a support at least one coupler represented by formula (I): ##STR1## wherein R.sup.1 represents hydrogen atom or a substituent; R.sup.2 represents a substituent; X represents hydrogen atom or a group releasable on a coupling reaction with an oxidation product of a color developing agent; Z.sup.1 represents a nonmetallic atom group necessary for forming a nitrogen-containing, six-membered, heterocyclic ring which has at least one dissociative group: Z.sup.1 cannot be --C(.dbd.O)--N(R)--C(.dbd.O)--NH--; and R represents a substituent.Also disclosed is a novel dye forming coupler which exhibits a high coupling activity and which gives a dye having a large molar extinction coefficient and superior stability, the coupler being represented by the following formula (XX) or (XXI). Also disclosed is a silver halide color photosensitive material which contains at least one of the dye forming couplers of formulae (XX) and (XXI) and which provides sharp dye images with high fastness properties. ##STR2## wherein EWG represents an electron withdrawing group having a Hammett's .sigma..sub.p value of not less than 0.3; R.sub.1 and R.sub.2 each represent a substituent; and X represents hydrogen atom or a group releasable on a coupling reaction with an oxidation product of an aromatic primary amine developing agent.

    摘要翻译: 一种卤化银色感光材料,其形成具有优异耐热性且不易在还原气氛中褪色的青色染料。 卤化银色感光材料在载体上至少一层中含有至少一个由式(I)表示的成色剂:汤姆或取代基; R2表示取代基; X表示氢原子或可与显色剂的氧化产物偶联反应脱离的基团; Z1表示形成具有至少一个解离基团的含氮六元杂环所必需的非金属原子团:Z1不能为-C(= O)-N(R)-C(= O)-NH - ; R表示取代基。 还公开了一种新型的染料形成成色剂,其显示出高的偶联活性,并且得到具有大的摩尔吸光系数和优异的稳定性的染料,所述成色剂由下式(XX)或(XXI)表示。 还公开了含有式(XX)和(XXI)的染料形成成色剂中的至少一种的卤化银色感光材料,并提供具有高坚牢度性质的清晰的染料图像。 (XXI)(XXI)其中EWG表示哈米特σp值不小于0.3的吸电子基团; R1和R2各自表示取代基; X表示氢原子或可与芳族伯胺显影剂的氧化产物偶联反应脱离的基团。

    Cyan image forming method and silver halide color photographic material
containing cyan coupler

    公开(公告)号:US5270153A

    公开(公告)日:1993-12-14

    申请号:US797977

    申请日:1991-11-26

    IPC分类号: G03C7/305 G03C7/38 G03C7/407

    CPC分类号: G03C7/30529 G03C7/383

    摘要: A silver halide color photographic material comprising a support having thereon at least one light-sensitive silver halide emulsion layer containing at least one 1H-pyrrolo[2,1-c][1,2,4]triazole cyan coupler represented by the following general formula (I) or (II): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represents a hydrogen atom or a substituent, provided that at least one of R.sub.1 and R.sub.2 is an electron withdrawing group which has a Hammett's substituent constant .sigma.p value of 0.15 or more; R.sub.1 and R.sub.2 may be bonded to form a ring; and X represents a hydrogen atom or a substituent capable of being released upon coupling with an oxidation product of an aromatic primary amine color developing agent; said coupler may form a bis-compound or or a polymer at R.sub.1, R.sub.2, R.sub.3 or X; and a cyan image forming method comprising imagewise exposing a silver halide color photographic material comprising a support having thereon at least one light-sensitive silver halide emulsion layer and subjecting the exposed photographic material to color development with an aromatic primary amine color dveloping agent at the presence of the above-described 1H-pyrrolo[2,1c][1,2,4]triazole cyan coupler.