-
公开(公告)号：US20100120088A1
公开(公告)日：2010-05-13
申请号：US12430592
申请日：2009-04-27
申请人： Masato IKEDA , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
发明人： Masato IKEDA , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/227
摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.
摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。
-
公开(公告)号：US20050079586A1
公开(公告)日：2005-04-14
申请号：US10497502
申请日：2002-12-03
申请人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
发明人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
IPC分类号： C12N1/21 , C12N9/04 , C12N15/53 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/22 , C07H21/04 , C12N15/74
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/227
摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.
摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码该多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。
-
公开(公告)号：US07524667B2
公开(公告)日：2009-04-28
申请号：US10497502
申请日：2002-12-03
申请人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
发明人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/227
摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.
摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。
-
公开(公告)号：US07989191B2
公开(公告)日：2011-08-02
申请号：US12430592
申请日：2009-04-27
申请人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
发明人： Masato Ikeda , Junko Ohnishi , Satoshi Mitsuhashi , Keiko Ochiai
CPC分类号： C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/227
摘要： The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s) of the amino acid sequence shown in SEQ ID NO: 1, and having GND activity; DNA encoding the polypeptide; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a microorganism carrying the DNA on the chromosome; and a process for producing a useful substance which comprises culturing the transformant or the microorganism in a medium.
摘要翻译： 本发明涉及一种多肽，其具有衍生自属于棒杆菌属的微生物的6-磷酸葡糖酸脱氢酶（以下简写为GND）的修饰氨基酸序列，所述修饰是将位点（ s）对应于SEQ ID NO：1所示氨基酸序列的第158位和/或第361位氨基酸，并具有GND活性; 编码多肽的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 在染色体上携带DNA的微生物; 以及生产有用物质的方法，包括在培养基中培养转化体或微生物。
-
公开(公告)号：US06893848B1
公开(公告)日：2005-05-17
申请号：US09958606
申请日：2000-04-14
申请人： Haruhiko Yokoi , Junko Ohnishi , Keiko Ochiai , Yoshiyuki Yonetani , Akio Ozaki
发明人： Haruhiko Yokoi , Junko Ohnishi , Keiko Ochiai , Yoshiyuki Yonetani , Akio Ozaki
CPC分类号： C12N9/1217 , C12P13/08
摘要： The present invention relates to a novel aspartokinase derived from a Coryneform bacterium; a DNA encoding the enzyme; a recombinant DNA containing the above DNA; a Coryneform bacterium having the above recombinant DNA or a Coryneform bacterium having the DNA on its chromosome; and a process for producing L-lysine by culturing the above microorganism. Construction has been successfully made of a DNA encoding an aspartokinase freed from concerted feedback inhibition by L-lysine and L-threonine derived from a Corynebacterium and has a nucleotide sequence encoding an amino acid sequence wherein the amino acid residue at position 311 is an amino acid other than Thr in the amino acid sequence shown by SEQ ID NO: 18.
摘要翻译： 本发明涉及一种衍生自棒状杆菌属细菌的新型天冬氨酸激酶; 编码酶的DNA; 含有上述DNA的重组DNA; 具有上述重组DNA的棒状细菌或其染色体上具有DNA的棒状细菌; 以及通过培养上述微生物来生产L-赖氨酸的方法。 已经成功制备了编码天冬氨酸的DNA，其不含由L-赖氨酸和由棒状杆菌衍生的L-苏氨酸的协同反馈抑制，并且具有编码氨基酸序列的核苷酸序列，其中311位的氨基酸残基是氨基酸 SEQ ID NO：18所示的氨基酸序列中的Thr除外。
-
6.发明授权Mutant of homoserine dehydrogenase from Corynebacterium and DNA encoding thereof 有权来自棒杆菌的高丝氨酸脱氢酶突变体及其编码的DNA公开(公告)号：US07332310B2
公开(公告)日：2008-02-19
申请号：US10805394
申请日：2004-03-22
申请人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
发明人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
CPC分类号： C12N9/93 , C07K14/34 , C12N9/0004 , C12P13/08 , C12R1/15 , C12Y101/01003 , C12Y604/01001
摘要： Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
摘要翻译： 衍生自属于棒状细菌的微生物及其片段的新型多核苷酸，由多核苷酸及其片段编码的多肽，包含多核苷酸及其片段的多核苷酸阵列，其中已记录了多核苷酸及其片段的核苷酸序列是可读的 在电脑中，并使用它们。
-
公开(公告)号：US20060228712A1
公开(公告)日：2006-10-12
申请号：US10805394
申请日：2004-03-22
申请人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
发明人： Satoshi Nakagawa , Hiroshi Mizoguchi , Seiko Ando , Mikiro Hayashi , Keiko Ochiai , Haruhiko Yokoi , Naoko Tateishi , Akihiro Senoh , Masato Ikeda , Akio Ozaki
CPC分类号： C12N9/93 , C07K14/34 , C12N9/0004 , C12P13/08 , C12R1/15 , C12Y101/01003 , C12Y604/01001
摘要： Novel polynucleotides derived from microorganisms belonging to coryneform bacteria and fragments thereof, polypeptides encoded by the polynucleotides and fragments thereof, polynucleotide arrays comprising the polynucleotides and fragments thereof, recording media in which the nucleotide sequences of the polynucleotide and fragments thereof have been recorded which are readable in a computer, and use of them.
摘要翻译： 衍生自属于棒状细菌的微生物及其片段的新型多核苷酸，由多核苷酸及其片段编码的多肽，包含多核苷酸及其片段的多核苷酸阵列，其中记录了多核苷酸及其片段的核苷酸序列是可读的记录介质 在电脑中，并使用它们。
-
公开(公告)号：US07037672B2
公开(公告)日：2006-05-02
申请号：US10419095
申请日：2003-04-21
申请人： Chiaki Saitoh , Atsushi Yashiro , Chikara Tokunaga , Kyoko Ozawa , Atsuko Yokoi , Nobuo Ogata , Hiroshi Katahira , Keiko Ochiai , Katsuhiko Ando
发明人： Chiaki Saitoh , Atsushi Yashiro , Chikara Tokunaga , Kyoko Ozawa , Atsuko Yokoi , Nobuo Ogata , Hiroshi Katahira , Keiko Ochiai , Katsuhiko Ando
IPC分类号： C12P1/00
CPC分类号： C12R1/15 , A23B7/10 , A23L27/24 , C12P17/04 , Y10S435/843
摘要： The present invention relates to a novel flavoring solution for making pickles having a flavor of foods pickled in rice bran paste (hereinafter referred to as a bran pickles flavoring solution), a clear bran pickles flavoring solution, processes for producing said solutions, a novel microorganism belonging to the genus Corynebacterium used for the production of said flavoring solutions, and a process for producing a solution containing a lactone wherein the lactone is selectively extracted from a culture of a lactone-producing microorganism.The present invention also relates to a novel bacterium of the genus Corynebacterium which has the ability to produce γ-dodecalactone and/or γ-dodecelactone and is useful for the production of said bran pickles flavoring solutions.
-
公开(公告)号：US5663298A
公开(公告)日：1997-09-02
申请号：US730348
申请日：1996-10-15
申请人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Ritsuko Katahira , Atsuhiro Hasegawa , Keiko Ochiai , Shiro Akinaga
发明人： Tamio Mizukami , Akira Asai , Yoshinori Yamashita , Ritsuko Katahira , Atsuhiro Hasegawa , Keiko Ochiai , Shiro Akinaga
CPC分类号： C07K5/06026 , A61K38/00
摘要： The present invention relates to UCK14 compounds having antitumor activity which are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOC(CH.sub.3).sub.3 ; and R.sup.2 and R.sup.3 are taken together to form --CH.sub.2 --, or each R.sup.2 and R.sup.3 independently are hydrogen,and pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及具有抗肿瘤活性的UCK14化合物，其由下式表示：其中R 1为氢或-COOC（CH 3）3; 并且R 2和R 3一起形成-CH 2 - ，或每个R 2和R 3独立地是氢，及其药学上可接受的盐。
-
10.发明授权Process for producing optically active 4-hydroxy-2-ketoglutaric acid using microorganisms 失效使用微生物生产光学活性的4-羟基-2-酮戊二酸的方法
公开(公告)号：US5607848A
公开(公告)日：1997-03-04
申请号：US395707
申请日：1995-02-28
CPC分类号： C12R1/41 , C12P7/50 , Y10S435/822 , Y10S435/874 , Y10S435/877
摘要： The present invention provides a process for producing an optically active 4-hydroxy-2-ketoglutaric acid, by mixing glyoxylic acid, pyruvic acid and a microorganism to form the optically active 4-hydroxy-2-ketoglutaric acid in an aqueous medium.
摘要翻译： 本发明提供了通过在水性介质中混合乙醛酸，丙酮酸和微生物以形成光学活性的4-羟基-2-酮戊二酸来制备光学活性的4-羟基-2-酮戊二酸的方法。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.034 秒)
