公开(公告)号：US06692758B1

公开(公告)日：2004-02-17

申请号：US09806151

申请日：2001-03-28

申请人： Masatoshi Ito ,  Yuriko Kawai ,  Seiji Okazaki ,  Masahiko Tanahashi ,  Kang Jung Kim ,  Miho Iwase

发明人： Masatoshi Ito ,  Yuriko Kawai ,  Seiji Okazaki ,  Masahiko Tanahashi ,  Kang Jung Kim ,  Miho Iwase

IPC分类号： A61K31663

CPC分类号： A61K31/663 ,  A61L27/54 ,  A61L2300/216 ,  A61L2300/432 ,  C07F9/3839

摘要： The present invention relates to an implant attachment stabilizer having, as an effective component, a methanebisphosphonic acid derivative represented by general formula (I) [where, in the formula, X, Y, m, n, , A, B, R1, R2, R3 and R4 are as defined in the Specification], or hydrate thereof. The methanebisphosphonic acid derivatives represented by general formula (I) or the hydrates thereof, to which the present invention relates, have an interstitial tissue proliferation inhibiting action and an osteolytic factor production inhibiting action and, in particular, since they inhibit osteolysis through the inhibition of the interstitial tissue proliferation which accompanies implant attachment and the inhibition of osteolysis factor production at the implant periphery, they are effective in the prevention of implant loosening and detachment, and it is possible to extend the implant attachment period in the case of implants such as artificial joints, and implants in the oro-dental field.

摘要翻译： 本发明涉及具有通式（I）表示的甲烷二膦酸衍生物作为有效成分的植入物附着稳定剂[式中，X，Y，m，n，，A，B，R 1，R 2，R 本发明涉及的通式（I）表示的甲烷二膦酸衍生物或其水合物具有间质组织增殖抑制作用 并且特别是由于它们通过抑制伴随植入物附着的间质组织增殖和抑制植入物周围的骨质疏松因子产生而抑制骨质溶解，因此它们有效地防止植入物松动和 脱离，它是可能的 e以在诸如人造关节的植入物和牙科领域中的植入物的情况下延长植入物固定周期。

公开(公告)号：US06670343B1

公开(公告)日：2003-12-30

申请号：US09787182

申请日：2001-05-29

申请人： Masatoshi Ito ,  Seiji Okazaki ,  Yuriko Kawai ,  Norio Kawabe

发明人： Masatoshi Ito ,  Seiji Okazaki ,  Yuriko Kawai ,  Norio Kawabe

IPC分类号： A61K31663

CPC分类号： A61K31/663 ,  Y10S514/90 ,  Y10S514/902

摘要： An agent for periodontal disease includes, as an active component, a methanebisphosphonic acid derivative or a hydrate thereof represented by the general formula (I): [wherein X, Y, m, n, The methanebisphosphonic acid derivative represented by the general formula (I) or a hydrate thereof according to the present invention has activities such as inhibitory effect on cell infiltration to the affected part associated with periodontal disease, and is useful for the prophylaxis or treatment of periodontal disease.

摘要翻译： 作为牙周病的药剂，可以举出通式（I）表示的甲烷二膦酸衍生物或其水合物作为活性成分：[其中，X，Y，m，n，由通式（I）表示的甲烷二膦酸衍生物 ）或其水合物具有诸如对与牙周病相关的患部的细胞浸润的抑制作用的活性，并且可用于预防或治疗牙周病。

公开(公告)号：US06555529B1

公开(公告)日：2003-04-29

申请号：US09380090

申请日：1999-08-25

申请人： Yuriko Funaba ,  Junzo Koike ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

发明人： Yuriko Funaba ,  Junzo Koike ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

IPC分类号： A61K3166

CPC分类号： A61K31/66 ,  A61K31/663 ,  A61K31/675

摘要： The present invention has the objective of offering drug for treating abnormalities in bone marrow which corrects the biological balance in the bone marrow, in particular which has the effect of suppressing inflammatory cell infiltration and suppressing cell growth-differentiation factor increase. The present invention relates to drug for treating abnormalities in bone marrow which has, as an effective component, a methanebisphosphonic acid derivative, ester thereof, medicinally acceptable salt thereof, or a hydrate of these. The methanebisphosphonic acid derivatives of the present invention show an outstanding bone marrow abnormality therapeutic effect, so efficacy can be expected in the prevention and treatment of rheumatoid arthritis, multiple myeloma, osteomyelitis and other bone marrow abnormalities. Furthermore, application can also be expected in the prevention and treatment of hypoplastic anaemia, myelocytic leukaemia and other such haematopoietic disorders.

摘要翻译： 本发明的目的是提供一种用于治疗骨髓中异常的药物，其用于校正骨髓中的生物平衡，特别是其具有抑制炎性细胞浸润和抑制细胞生长分化因子增加的作用。本发明涉及 作为有效成分的甲烷二膦酸衍生物，其酯，药学上可接受的盐或其水合物的骨髓中异常的药物。本发明的甲烷二膦酸衍生物显示出优异的骨髓异常治疗效果 因此预防和治疗类风湿性关节炎，多发性骨髓瘤，骨髓炎等骨髓异常的疗效。 此外，还可以预期在预防和治疗发育不全的贫血，骨髓性白血病和其他这种造血障碍中的应用。

公开(公告)号：US06579860B1

公开(公告)日：2003-06-17

申请号：US09623014

申请日：2000-09-27

申请人： Junzo Koike ,  Yuriko Funaba ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

发明人： Junzo Koike ,  Yuriko Funaba ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

IPC分类号： A61K31663

CPC分类号： A61K31/663 ,  A61K31/675

摘要： An interleukin-6 production inhibitor is provided containing a methanebisphosphonic acid derivative as an active component, which has inhibitory effects on interleukin-6 production and is useful in prevention and treatment of diseases due to abnormal production of the interleukin-6. This pharmaceutical is anticipated to have effects in prevention and treatment of diseases related to the interleukin-6, for example, thrombocytosis, inflammatory diseases, abnormal immune response diseases, osteoporosis, rheumatoid arthritis, hypercalcemia, multiple myeloma, cachexia, and nephritis.

摘要翻译： 提供了含有作为活性成分的甲烷二膦酸衍生物的白细胞介素-6产生抑制剂，其对白细胞介素-6产生具有抑制作用，并且可用于预防和治疗由于白细胞介素-6异常产生引起的疾病。 预期该药物可预防和治疗与白细胞介素-6相关的疾病，例如血小板增多症，炎性疾病，异常免疫应答疾病，骨质疏松症，类风湿性关节炎，高钙血症，多发性骨髓瘤，恶病质和肾炎。

公开(公告)号：US20130045421A1

公开(公告)日：2013-02-21

申请号：US13503155

申请日：2010-10-21

申请人： Masashi Kobino ,  Katsuhiro Fujita ,  Shoichi Fujino ,  Akihisa Kajiyama ,  Ryuta Masaki ,  Daisuke Morita ,  Takayuki Yamamura ,  Tetsuya Kodaira ,  Minoru Yamasaki ,  Seiji Okazaki ,  Toshiaki Hiramoto ,  Akino Sato ,  Wataru Oda ,  Kenji Okinaka

发明人： Masashi Kobino ,  Katsuhiro Fujita ,  Shoichi Fujino ,  Akihisa Kajiyama ,  Ryuta Masaki ,  Daisuke Morita ,  Takayuki Yamamura ,  Tetsuya Kodaira ,  Minoru Yamasaki ,  Seiji Okazaki ,  Toshiaki Hiramoto ,  Akino Sato ,  Wataru Oda ,  Kenji Okinaka

IPC分类号： H01M4/525 ,  B32B5/16 ,  C01G53/04

CPC分类号： C01G45/006 ,  C01G45/1221 ,  C01G51/006 ,  C01G51/44 ,  C01G53/006 ,  C01G53/42 ,  C01G53/44 ,  C01P2002/52 ,  C01P2002/60 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/51 ,  C01P2004/61 ,  C01P2006/11 ,  C01P2006/12 ,  C01P2006/40 ,  H01M4/505 ,  H01M4/525 ,  H01M10/052 ,  Y10T428/2982

摘要： The present invention relates to nickel-cobalt-manganese-based compound particles which have a volume-based average secondary particle diameter (D50) of 3.0 to 25.0 μm, wherein the volume-based average secondary particle diameter (D50) and a half value width (W) of the peak in volume-based particle size distribution of secondary particles thereof satisfy the relational formula: W≦0.4×D50, and can be produced by dropping a metal salt-containing solution and an alkali solution to an alkali solution at the same time, followed by subjecting the obtained reaction solution to neutralization and precipitation reaction. The nickel-cobalt-manganese-based compound particles according to the present invention have a uniform particle size, a less content of very fine particles, a high crystallinity and a large primary particle diameter, and therefore are useful as a precursor of a positive electrode active substance used in a non-aqueous electrolyte secondary battery.

摘要翻译： 本发明涉及体积平均二次粒径（D50）为3.0〜25.0μm的镍钴锰系化合物粒子，其中体积平均二次粒径（D50）和半值宽度 二次粒子的体积基准粒径分布峰的（W）满足关系式：W＆nlE; 0.4×D50，可以通过在金属盐溶液中滴加含金属盐的溶液和碱溶液至碱溶液 同时对所得反应溶液进行中和沉淀反应。 本发明的镍钴锰系化合物粒子的粒径均匀，粒子含量少，结晶性高，初级粒径大，因此可用作正极的前体 用于非水电解质二次电池的活性物质。

公开(公告)号：US07431908B2

公开(公告)日：2008-10-07

申请号：US10938539

申请日：2004-09-13

申请人： Toshiharu Harada ,  Yuji Mishima ,  Seiji Okazaki ,  Haruki Kurokawa ,  Hidetomo Unemoto ,  Kazuyoshi Murashige ,  Manabu Matsumoto ,  Tadashi Kanasaku

发明人： Toshiharu Harada ,  Yuji Mishima ,  Seiji Okazaki ,  Haruki Kurokawa ,  Hidetomo Unemoto ,  Kazuyoshi Murashige ,  Manabu Matsumoto ,  Tadashi Kanasaku

IPC分类号： B32B18/00 ,  B32B31/00

CPC分类号： H01G4/1227 ,  C01G23/006 ,  C01P2002/34 ,  C01P2002/76 ,  C01P2002/80 ,  C01P2004/32 ,  C01P2004/52 ,  C01P2004/62 ,  C01P2004/86 ,  C01P2006/12 ,  C01P2006/40 ,  C04B35/4682 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Spherical tetragonal barium titanate particles of the present invention have a perovskite crystal structure, an average particle diameter of 0.05 to 0.5 μm, a particle size distribution σg of not less than 0.70, and a ratio of Ba to Ti of 0.99:1 to 1.01:1. The spherical tetragonal barium titanate particles exhibit an excellent dispersibility as well as a high denseness, a high purity and excellent permittivity properties.

摘要翻译： 本发明的球形四方钛酸钡颗粒具有钙钛矿晶体结构，平均粒径为0.05〜0.5μm，粒径分布sigmag为0.70以上，Ba与Ti的比例为0.99:1〜1.01μm。 1。 球形四方钛酸钡颗粒表现出优异的分散性以及高致密度，高纯度和优异的介电常数性质。

公开(公告)号：US06808697B2

公开(公告)日：2004-10-26

申请号：US09986657

申请日：2001-11-09

申请人： Toshiharu Harada ,  Yuji Mishima ,  Seiji Okazaki ,  Haruki Kurokawa ,  Hidetomo Unemoto ,  Kazuyoshi Murashige ,  Manabu Matsumoto ,  Tadashi Kanasaku

发明人： Toshiharu Harada ,  Yuji Mishima ,  Seiji Okazaki ,  Haruki Kurokawa ,  Hidetomo Unemoto ,  Kazuyoshi Murashige ,  Manabu Matsumoto ,  Tadashi Kanasaku

IPC分类号： C01G2300

CPC分类号： H01G4/1227 ,  C01G23/006 ,  C01P2002/34 ,  C01P2002/76 ,  C01P2002/80 ,  C01P2004/32 ,  C01P2004/52 ,  C01P2004/62 ,  C01P2004/86 ,  C01P2006/12 ,  C01P2006/40 ,  C04B35/4682 ,  Y10T428/2991 ,  Y10T428/2993

摘要： Spherical tetragonal barium titanate particles of the present invention have a perovskite crystal structure, an average particle diameter of 0.05 to 0.5 &mgr;m, a particle size distribution &sgr;g of not less than 0.70, and a ratio of Ba to Ti of 0.99:1 to 1.01:1. The spherical tetragonal barium titanate particles exhibit an excellent dispersibility as well as a high denseness, a high purity and excellent permittivity properties.

摘要翻译： 本发明的球形四方钛酸钡颗粒具有钙钛矿晶体结构，平均粒径为0.05〜0.5μm，粒径分布sigmag为0.70以上，Ba与Ti的比例为0.99:1〜1.01μm。 1。 球形四方钛酸钡颗粒表现出优异的分散性以及高致密度，高纯度和优异的介电常数性质。

公开(公告)号：US07126248B2

公开(公告)日：2006-10-24

申请号：US11344327

申请日：2006-01-30

申请人： Noriyoshi Nishiyama ,  Yasufumi Ikkai ,  Seiji Okazaki

发明人： Noriyoshi Nishiyama ,  Yasufumi Ikkai ,  Seiji Okazaki

IPC分类号： H02K1/06 ,  H02K1/12

CPC分类号： F04B35/04 ,  F04C29/0085 ,  H02K1/148 ,  H02K15/022

摘要： A motor includes a stator formed by assembling plural divided-stator-members—each one of the members having a tooth—into an annular shape, and a rotor facing the stator. The divided stator members are formed by laminating plural core sheets and bonding at least parts of end faces along the laminating direction of the core sheets. This structure allows forming a lamination of the core sheets without welding, which avoids damaging electrical insulation between each core sheet. Eddy current thus does not increase at an inner rim of the stator, where magnetic flux intensely changes. The motor efficiency is, therefore, not adversely affected. As a result, a small, efficient and high performance motor in a simple structure is obtainable. A compressor employing the same motor and enjoying the advantages of the motor is also obtainable.

公开(公告)号：US4178615A

公开(公告)日：1979-12-11

申请号：US855472

申请日：1977-11-28

申请人： Riyo Shimooka ,  Masuo Kunisawa ,  Seiji Okazaki

发明人： Riyo Shimooka ,  Masuo Kunisawa ,  Seiji Okazaki

IPC分类号： G03B27/32 ,  B41J2/465 ,  G02B27/09 ,  G03F1/00 ,  G06K15/12 ,  H04N1/036 ,  H04N1/23 ,  H04N1/22 ,  G03B27/50 ,  G03B27/68 ,  G11B7/18

CPC分类号： B41J2/465 ,  G06K15/12 ,  H04N1/036

摘要： An aperture plate for use in the exposure head of a picture scanning reproducer which constructs an image by exposure of a film attached to a rotating drum in scanning mode, the aperture of which plate has a shape incorporating parallel lines and end portions consisting of twin lines opening up away from a cusp, which in some embodiments may be exponential curves, whereby overlap effects in the constructed image are substantially eliminated.

摘要翻译： 一种用于图像扫描再现器的曝光头的光圈板，其通过以扫描模式曝光附着在旋转鼓上的胶片来构造图像，该板的孔径具有平行线和由双线组成的端部的形状 从尖端开口，其在一些实施例中可以是指数曲线，由此基本上消除了构造图像中的重叠效应。

公开(公告)号：US4160280A

公开(公告)日：1979-07-03

申请号：US854698

申请日：1977-11-25

申请人： Hitomi Atoji ,  Masuo Kunisawa ,  Riyo Shimooka ,  Seiji Okazaki

发明人： Hitomi Atoji ,  Masuo Kunisawa ,  Riyo Shimooka ,  Seiji Okazaki

IPC分类号： G02B26/10 ,  H04N1/028 ,  H04N1/24

CPC分类号： H04N1/02815 ,  G02B26/10

摘要： A picture scanner using a light beam which has first passed through a mask plate to scan a picture fixed to a revolving cylinder is provided with a system for adjusting the transverse position of the light source, consisting of a mirror which can be pivoted into the path of the light beam, a screen on which an image of the light source and an image of the mask plate can be simultaneously projected, and means for focusing both these images into the same plane.