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公开(公告)号：US20240399019A1
公开(公告)日：2024-12-05
申请号：US18606479
申请日：2024-03-15
Applicant: Massachusetts Institute of Technology
Inventor： Jingjing Wu , Jue Deng , Hyunwoo Yuk , Xuanhe Zhao
Abstract: Methods of implanting biomaterials and devices in a patient, such as methods that include arranging an adhesive composition between and in contact with a biomaterial or a device, and a surface of a tissue of the patient. An adhesive composition may be configured to form at a surface of a tissue a conformal interface that reduces or minimizes infiltration of inflammatory cells at the conformal interface.
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公开(公告)号：US20200299466A1
公开(公告)日：2020-09-24
申请号：US16807533
申请日：2020-03-03
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Baoyang Lu
IPC: C08J3/075 , C08G61/12 , C08F212/14 , H01B1/12
Abstract: Pure conducting hydrogel precursors and hydrogels formed of pure conducting polymer materials having a combination of high electrical conductivity, high stretchability, low Young's modulus, superior mechanical, electrical and electrochemical stability, and tunable swelling behaviors in wet physiological environments. The hydrogel precursors and hydrogels are fabricated by adding a polar organic solvent to an aqueous solution of the pure conducting polymer material, followed by controlled dry-annealing to form a hydrogel precursor which can be subsequently rehydrated to form a pure conducting polymer hydrogel which comprises at least 99% of the pure conducting polymer.
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公开(公告)号：US12157801B2
公开(公告)日：2024-12-03
申请号：US16866584
申请日：2020-05-05
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Akihisa Inoue
IPC: C08J5/12 , A61L27/34 , A61L31/10 , C08L75/04 , C08L101/12 , C09J9/00 , C09J175/04 , C25D9/02
Abstract: Adhesion of conducting polymers on diverse insulating and conductive substrates via a hydrophilic adhesion layer, where one or more functional groups may be disposed between the substrate and the hydrophilic adhesion layer. Adhesion of the conducting polymers on the substrates is such that adhesion is maintained or substantially maintained in wet physiological environments.
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公开(公告)号：US12084604B2
公开(公告)日：2024-09-10
申请号：US17666642
申请日：2022-02-08
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Heejung Roh
CPC classification number: C09J7/32 , C09J7/25 , C09J2301/12 , C09J2301/306 , C09J2301/414 , C09J2405/00 , C09J2433/00 , C09J2475/006 , Y10T428/28 , Y10T428/2852
Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
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公开(公告)号：US20210380848A1
公开(公告)日：2021-12-09
申请号：US17327944
申请日：2021-05-24
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Xiaoyu Chen
Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.
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Patent Agency Ranking
公开(公告)号：US10954375B2
公开(公告)日：2021-03-23
申请号：US15172131
申请日：2016-06-02
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Xuanhe Zhao , Shaoting Lin , Hyunwoo Yuk , Teng Zhang , German A P Hernandez
IPC: C08L33/26 , C09D201/02 , B32B27/04 , B32B27/30 , B05D3/04 , B05D3/10 , C08L35/00 , C09D133/26 , C09D135/00 , C09J133/26 , C09J135/00 , H01B1/12
Abstract: A robust hydrogel-solid hybrid formed of a substrate material having a nonporous and non-topographically patterned surface and a tough hydrogel bonded to the surface, the tough hydrogel having over 90 wt % water, and the hydrogel being bonded to provide interfacial toughness over 300 Jm−2, and even over 1000 Jm−2. The hydrogel is formed of polyacrylamide or polyethylene glycol diacrylate, which provide long-chain polymer networks, and chitosan, hyaluronan, or alginate, which provide mechanically dissipative components. An anchor, which can be a silane, a sulfide, or an amine, is disposed between the surface and the hydrogel to provide chemical bonding between the surface and the long-chain networks of the hydrogel.
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公开(公告)号：US20240238476A1
公开(公告)日：2024-07-18
申请号：US18421735
申请日：2024-01-24
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk
CPC classification number: A61L24/0031 , A61B5/1102 , A61B5/68335 , A61K9/7084 , A61L24/043 , B32B9/02 , B32B29/002 , A61B2562/0261 , A61F2013/00676 , B32B2307/7163 , B32B2307/748 , B32B2405/00 , B32B2535/00
Abstract: A method of adhering wet tissues together includes providing a dry adhesive material that contains one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers. The method including the steps of placing the dry adhesive material in contact with one or more wet tissue surfaces; allowing the dry adhesive material to absorb liquid from the one or more wet surfaces to thereby swell the adhesive material; allowing instant crosslinking by intermolecular interactions between the adhesive material and the one or more wet surfaces; and allowing quick covalent crosslinking between the adhesive material and the one or more wet surfaces.
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公开(公告)号：US20240132758A1
公开(公告)日：2024-04-25
申请号：US18535124
申请日：2023-12-11
Applicant: Massachusetts Institute of Technology , Mayo Foundation for Medical Education and Research
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Xinyu Mao , Christoph Nabzdyk
IPC: C09J105/08 , A61L24/00 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/00
CPC classification number: C09J105/08 , A61L24/0042 , A61L24/0094 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/003 , A61L2400/04 , C09J2483/00
Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
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公开(公告)号：US11364658B2
公开(公告)日：2022-06-21
申请号：US16374267
申请日：2019-04-03
Applicant: Massachusetts Institute of Technology
Inventor： Yoonho Kim , Xuanhe Zhao , Hyunwoo Yuk
Abstract: A responsive material having an elastomeric matrix in which ferromagnetic particles are dispersed so as to have a predetermined magnetization pattern which, when exposed to an external magnetic field, changes the shape of the responsive material from an initial shape to a predetermined transformed shape dictated by the magnetization pattern. An initial shape of the responsive material is formed by direct ink printing while applying magnetic fields to a dispensing nozzle to align the particles and gives rise to the desired magnetization pattern.
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公开(公告)号：US20210350725A1
公开(公告)日：2021-11-11
申请号：US17193910
申请日：2021-03-05
Applicant: Massachusetts Institute of Technology
Inventor： Clara Park , Xuanhe Zhao , Hyunwoo Yuk , Christopher Tam Nguyen , Ellen T. Roche
Abstract: A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.
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