利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.027 seconds)

    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS
    1.
    发明申请
    MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS 审中-公开
    微型或三维印刷的流感疫苗制剂

    公开(公告)号：US20150165020A1

    公开(公告)日：2015-06-18

    申请号：US14572631

    申请日：2014-12-16

    Applicant: Massachussetts Institute of Technology ,  Tokitae LLC

    Inventor： Ana Jaklenec ,  William Gates ,  Philip A. Eckhoff ,  Boris Nikolic ,  Lowell L. Wood, JR. ,  Robert S. Langer

    IPC: A61K39/39

    CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6093 ,  C12N2770/32634 ,  Y02A50/466

    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

    Abstract translation: 已经开发了用于单次注射抗原的乳液基和微成型（“MM”）或三维印刷（“3DP”）聚合物制剂，优选在两个或更多个时间段内释放。 制剂优选由生物相容的可生物降解的聚合物形成。 单独或与其他抗原，佐剂，稳定剂和释放调节剂组合的包封抗原的离散区域存在于制剂中。 抗原优选在给药时或赋形剂的表面存在于赋形剂中，用于立即释放，并且在初始释放抗原后10至45天，任选地以10至90天的间隔，并入引发至制剂内以释放 在一个或多个额外的时间段内释放抗原。 抗原可以通过使用稳定剂例如海藻糖玻璃来稳定。 在针对小儿麻痹症免疫的优选实施方案中，抗原在给药时释放，其后两个，四个月和六个月。

    Multi-compartment pharmaceutical vials
    4.
    发明授权
    Multi-compartment pharmaceutical vials 有权
    多间隔药瓶

    公开(公告)号：US09237985B2

    公开(公告)日：2016-01-19

    申请号：US13945499

    申请日：2013-07-18

    Applicant: Tokitae LLC

    Inventor： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Orin Levine ,  Nels R. Peterson ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

    IPC: A61J1/06 ,  A61J1/14 ,  A61J1/20

    CPC classification number: A61J1/1425 ,  A61J1/05 ,  A61J1/1406

    Abstract: Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.

    Abstract translation: 描述了多室药物小瓶。 在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少 一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且 每个导管的第二端围绕与底壁相对定位的孔。

    Temperature-controlled storage systems
    5.
    发明授权
    Temperature-controlled storage systems 有权
    温度控制存储系统

    公开(公告)号：US09140476B2

    公开(公告)日：2015-09-22

    申请号：US13853245

    申请日：2013-03-29

    Applicant: Tokitae LLC

    Inventor： Philip A. Eckhoff ,  William Gates ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr.

    IPC: F25D23/12 ,  F25D3/12 ,  B65D81/38 ,  B65D51/16

    CPC classification number: F25D3/125 ,  B65D51/1644 ,  B65D81/3802 ,  B65D81/3811 ,  B65D81/3813 ,  B65D81/3823 ,  B65D81/3825 ,  B65D81/3834 ,  B65D81/3837 ,  B65D81/3888 ,  B65D81/3897 ,  B65D2203/10

    Abstract: In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.

    Abstract translation: 在一些实施例中，基本上热密封的储存容器包括外部组件和与容器成一体的蒸发冷却组件。 在一些实施例中，外部组件包括基本上限定至少一个热控储存区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。 在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸汽导管，所述蒸汽管道包括第一端和第二端，所述第一端附接到所述蒸发冷却单元，所述第二端连接到所述干燥剂单元; 以及连接到蒸气导管的蒸气控制单元。

    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS
    6.
    发明申请
    REFRIGERATION DEVICES INCLUDING TEMPERATURE-CONTROLLED CONTAINER SYSTEMS 有权
    包括温度控制容器系统的制冷装置

    公开(公告)号：US20150233617A1

    公开(公告)日：2015-08-20

    申请号：US14704107

    申请日：2015-05-05

    Applicant: Tokitae LLC

    Inventor： Fong-Li Chou ,  Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  William Gates ,  Jennifer Ezu Hu ,  Muriel Y. Ishikawa ,  Fridrik Larusson ,  Shieng Liu ,  Nathan P. Myhrvold ,  Brian L. Pal ,  Nels R. Peterson ,  David Keith Piech ,  Maurizio Vecchione ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood ,  David J. Yager

    IPC: F25B39/02 ,  F25B49/02

    CPC classification number: F25B39/028 ,  F25B49/00 ,  F25B49/02 ,  F25B2339/02 ,  F25D11/006 ,  F25D11/025

    Abstract: In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

    Abstract translation: 在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统，其包括具有中空内部的第一组不透气结构，以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器，具有中空内部连接的第二组蒸气不可渗透结构 以形成与基本上形成存储区域的壁热接触的蒸发器，以及具有固定到冷凝器和蒸发器两者的中空内部的连接器，所述连接器在冷凝器的中空内部和 中空的蒸发器内部。

    Multi-monodose containers
    9.
    发明授权
    Multi-monodose containers 有权

    公开(公告)号：US10342735B2

    公开(公告)日：2019-07-09

    申请号：US14736542

    申请日：2015-06-11

    Applicant: Tokitae LLC

    Inventor： Fong-Li Chou ,  Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  Shieng Liu ,  Krishnan Natarajan ,  Nels R. Peterson ,  Lowell L. Wood, Jr.

    IPC: A61J1/14 ,  A61J1/16 ,  A61J1/18

    Abstract: Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.

Patent Agency Ranking