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    Optical coherence tomography methods and systems
    4.
    发明授权
    Optical coherence tomography methods and systems 有权
    光学相干断层扫描方法和系统

    公开(公告)号：US08427653B2

    公开(公告)日：2013-04-23

    申请号：US13007470

    申请日：2011-01-14

    申请人： Martin Hacker ,  Christoph Hauger ,  Keith O'Hara ,  Scott Meyer

    发明人： Martin Hacker ,  Christoph Hauger ,  Keith O'Hara ,  Scott Meyer

    IPC分类号： G01B11/02

    CPC分类号： A61B3/102 ,  A61B3/1225 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/02009 ,  G01B9/02044 ,  G01B9/02091 ,  G01N21/4795

    摘要： Frequency domain optical coherence tomography (FD-OCT) systems and methods are provided. Thereby, a first measurement and a second measurement is performed, wherein in the first measurement an object region is illuminated by measuring light having a spectrum with a first spectral width and in the second measurement the object region is illuminated with measuring light having a spectrum with a second spectral width, wherein the first spectral width is at least 10% greater than the second spectral width. Further, during the first measurement intensities of spectral ranges of light having interacted with the object and being superimposed with reference light are detected, wherein a width of these spectral ranges is greater than a corresponding width during the second measurement. Thus, switching an axial field of view of structural information of the object across a depth direction is enabled upon minimizing radiation damage at the object.

    摘要翻译： 提供了频域光学相干断层扫描（FD-OCT）系统和方法。 由此，执行第一测量和第二测量，其中在第一测量中，通过测量具有第一光谱宽度的光谱的光照射对象区域，并且在第二测量中，用具有光谱的测量光照射对象区域 第二光谱宽度，其中所述第一光谱宽度比所述第二光谱宽度大至少10％。 此外，在第一测量期间，检测到与对象相互作用并与参考光叠加的光的光谱范围的强度，其中这些光谱范围的宽度大于第二测量期间的对应宽度。 因此，在最小化物体的辐射损伤的情况下，能够在深度方向上切换物体的结构信息的轴向视场。

    Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues
    5.
    发明申请
    Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues 有权
    生物图像数据处理方法，用于揭示病变组织的更有意义的解剖特征

    公开(公告)号：US20070103693A1

    公开(公告)日：2007-05-10

    申请号：US11223549

    申请日：2005-09-09

    申请人： Matthew Everett ,  Scott Meyer ,  Paul Stetson ,  Yan Zhou

    发明人： Matthew Everett ,  Scott Meyer ,  Paul Stetson ,  Yan Zhou

    IPC分类号： G01B9/02 ,  G06K9/00 ,  A61B5/05 ,  A61B5/103

    CPC分类号： A61B5/0066 ,  G06T7/0014 ,  G06T19/00 ,  G06T2200/24 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2210/41

    摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

    摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。

    Patterned spinning disk based optical phase shifter for spectral domain optical coherence tomography
    6.
    发明申请
    Patterned spinning disk based optical phase shifter for spectral domain optical coherence tomography 失效
    用于光谱相干层析成像的基于旋转圆盘的光学移相器

    公开(公告)号：US20060072424A1

    公开(公告)日：2006-04-06

    申请号：US10933795

    申请日：2004-09-03

    申请人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

    发明人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

    IPC分类号： G11B7/135

    CPC分类号： A61B3/102 ,  A61B3/1005 ,  G01B9/02012 ,  G01B9/02044 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/35

    摘要： A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.

    摘要翻译： 公开了一种低成本图案旋转盘，用于实现光束的相对快速的离散光学相移。 本发明在频域光学相干断层摄影系统中特别有用。 盘包含不同高度和/或折射率分布的阶梯图案，使得当其旋转时，通过或被盘反射的光束将经历不同的离散光学相位延迟。 磁盘可以作为移相器来操作，或者可以与强度调制斩波盘同步操作，也可以与光源进行直接强度调制。 磁盘还可以包含强度调制模式，使得可以同时实现相移和强度调制。 还公开了用于制造盘的各种可能的方法。

    Arrhythmia discrimination using ECG's sensed from multiple implanted electrodes
    8.
    发明授权
    Arrhythmia discrimination using ECG's sensed from multiple implanted electrodes 有权
    使用从多个植入电极感测的心电图进行心律失常辨别

    公开(公告)号：US08321002B2

    公开(公告)日：2012-11-27

    申请号：US13027608

    申请日：2011-02-15

    申请人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

    发明人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

    IPC分类号： A61B5/0464

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些能力的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。

    Adaptive windowing for cardiac waveform discrimination
    9.
    发明授权
    Adaptive windowing for cardiac waveform discrimination 有权
    心脏波形鉴别的自适应窗口

    公开(公告)号：US08145296B2

    公开(公告)日：2012-03-27

    申请号：US12538297

    申请日：2009-08-10

    申请人： Kevin J. Stalsberg ,  Yanting Dong ,  Scott Meyer ,  Eric K. Enrooth ,  Derek D. Bohn

    发明人： Kevin J. Stalsberg ,  Yanting Dong ,  Scott Meyer ,  Eric K. Enrooth ,  Derek D. Bohn

    IPC分类号： A61B5/042

    CPC分类号： A61N1/371 ,  A61B5/04525 ,  A61B5/0472 ,  A61B5/7217

    摘要： Cardiac devices and methods provide adaptation of detection windows used to determine a cardiac response to pacing. Adapting a detection window involves sensing a cardiac signal indicative of a particular type of cardiac pacing response, and detecting a feature of the sensed cardiac signal. The cardiac response detection window associated with the type of cardiac pacing response is preferentially adjusted based on the location of the detected cardiac feature. Preferential adjustment of the detection window may involve determining a direction of change between the detection window and the detected feature. The detection window may be adapted more aggressively in a more preferred direction and less aggressively in a less preferred direction.

    摘要翻译： 心脏装置和方法提供用于确定对起搏的心脏反应的检测窗口的适应。 适应检测窗口包括感测指示特定类型的心脏起搏反应的心脏信号，以及检测感测到的心脏信号的特征。 基于检测到的心脏特征的位置优先调整与心脏起搏响应类型相关联的心脏响应检测窗口。 检测窗口的优先调整可以包括确定检测窗口和检测到的特征之间的变化方向。 检测窗口可以在更优选的方向上更积极地改变，并且在较不优选的方向上较不积极地适配。