公开(公告)号：US09572517B2

公开(公告)日：2017-02-21

申请号：US13700660

申请日：2011-03-03

申请人： Seng Tat Ng ,  Xin Jiang ,  Hwee Siong Chong

发明人： Seng Tat Ng ,  Xin Jiang ,  Hwee Siong Chong

IPC分类号： A61B5/08 ,  A47D15/00 ,  A61B5/00 ,  A61B5/11 ,  G01L1/24

CPC分类号： A61B5/0816 ,  A47D15/003 ,  A61B5/0059 ,  A61B5/1128 ,  A61B5/6807 ,  A61B5/6892 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7455 ,  A61B5/746 ,  G01L1/242

摘要： A Baby Monitoring Mat is provided having a top mesh layer, a bottom mesh layer, two flexible sheets, and an optical cable. The optical cable can be routed between the top mesh layer and the bottom mesh layer. The flexible sheets are also between the top mesh layer and the bottom mesh layer forming a sensing area. A light source is provided for feeding light from one side of the optical cable to a photodiode for detecting light attenuation at the other end of the optical cable. A processor receives signals from the light source and photodiode and the signals are processed to determine movements and breath counts. The signals are generated based on the light attenuation changes along the optical fiber cable detected by photodiode. A method for monitoring baby on a mat is also provided.

摘要翻译： 提供了具有顶部网格层，底部网格层，两个柔性片和光缆的婴儿监视垫。 光缆可以在顶部网格层和底部网格层之间布置。 柔性片材也位于顶部网格层和底部网格层之间，形成感测区域。 提供光源用于将光从光缆的一侧馈送到用于检测光缆另一端的光衰减的光电二极管。 处理器从光源和光电二极管接收信号，并处理信号以确定运动和呼吸计数。 信号是根据由光电二极管检测到的光纤电缆的光衰减而产生的。 还提供了一种用于在垫上监测婴儿的方法。

公开(公告)号：US20130109931A1

公开(公告)日：2013-05-02

申请号：US13700660

申请日：2011-03-03

申请人： Seng Tat Ng ,  Xin Jiang ,  Hwee Siong Chong

发明人： Seng Tat Ng ,  Xin Jiang ,  Hwee Siong Chong

IPC分类号： A61B5/08 ,  A61B5/00 ,  A61B5/11

CPC分类号： A61B5/0816 ,  A47D15/003 ,  A61B5/0059 ,  A61B5/1128 ,  A61B5/6807 ,  A61B5/6892 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7455 ,  A61B5/746 ,  G01L1/242

摘要： The present invention provides a baby monitoring mat having a sensor mat having a top mesh layer, a bottom mesh layer, and two flexible sheets and an optical cable, wherein the optical cable is routed across and sandwiched in between the top mesh layer and the bottom mesh layer, and the flexible sheets further sandwiched the top mesh layer and the bottom mesh layer in between forming sensing area across the flexible sheet surface; a light source for feeding light from one side of the optical cable; a photodiode for detecting light attenuation at the other end of the optical cable; a printed circuit board having a processor connected to the light source and the photodiode, wherein the processor operationally receives signals from the photodiode, the signals are processed to determine movements and breath counts. The signals are generated based on the light attenuation changes along the optical fiber cable detected by photodiode, the light attenuation changes are operationally caused by the optical fiber bending lost caused by the movements and breath. A method for monitoring baby on a mat is also provided.

摘要翻译： 本发明提供了一种具有传感器垫的婴儿监护垫，该传感器垫具有顶部网层，底部网状层，以及两个柔性片和光缆，其中光缆穿过并夹在顶部网状物层和底部 网状层，并且柔性片材进一步夹在顶部网状物层和底部网状物层之间，形成感应区域穿过柔性片材表面; 用于从光缆的一侧馈送光的光源; 用于检测光缆另一端的光衰减的光电二极管; 具有连接到光源和光电二极管的处理器的印刷电路板，其中处理器可操作地接收来自光电二极管的信号，处理信号以确定运动和呼吸计数。 基于由光电二极管检测到的光纤电缆的光衰减变化产生信号，光衰减变化在操作上是由于运动和呼吸引起的光纤弯曲损耗引起的。 还提供了一种用于在垫上监测婴儿的方法。

公开(公告)号：US08765117B2

公开(公告)日：2014-07-01

申请号：US13375402

申请日：2010-06-10

申请人： Kenneth R. Chien ,  Lei Bu ,  Xin Jiang ,  Kathy Oi Lan Lui ,  Jolanta Chmielowiec

发明人： Kenneth R. Chien ,  Lei Bu ,  Xin Jiang ,  Kathy Oi Lan Lui ,  Jolanta Chmielowiec

IPC分类号： A01N63/00 ,  G01N33/53

CPC分类号： C12N5/0662 ,  A61K35/12 ,  C12N5/0657 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2501/415 ,  C12N2506/02

摘要： The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized human heart tissue from human primordial Islet1+ cardiovascular stem cells which are positive for markers ISL1+/NKX2.5−/KDR−. One aspect of the invention relates to isolation of human ISL1+ primordial cells from human pluripotent cells, such as human ES cells or other human pluripotent stem cell sources, wherein the human ISL1+ primordial cells can differentiate into three different lineages; cardiomyocyte lineages, endothelial lineages and smooth muscle lineages. Another aspect relates to use and implantation of the human primordial ISL1+ progenitors into an animal model to generate human vascularized heart tissue, and more particularly, the production of an in vivo humanized model of vascular disease. One embodiment relates to the use of an in vivo humanized model of vascular disease as an assay, for example to assess drug toxicity and/or identify agents which increase and decrease coronary blood flow to the human vascularized heart tissue. Another embodiment relates to the therapeutic use of human primordial ISL1+ progenitors, for example, in one embodiment the invention provides methods for the treatment cardiovascular disorders and/or congenital heart disease in a subject comprising transplanting into subjects vascularized human heart tissue generated from human ISL1+ progenitors.

摘要翻译： 本发明涉及从人原始Islet1阳性（ISL1 +）祖细胞产生血管化人心脏组织，更具体地说，从人原代Islet1 +心血管干细胞产生血管化人心脏组织，其对于标志物ISL1 + / NKX2.5是阳性的 - / KDR-。 本发明的一个方面涉及从人多能细胞例如人ES细胞或其他人多能干细胞来源分离人ISL1 +原始细胞，其中人ISL1 +原始细胞可分化成三种不同谱系; 心肌细胞谱系，内皮谱系和平滑肌谱系。 另一方面涉及将人原始ISL1 +祖细胞用于和植入动物模型中以产生人血管化的心脏组织，更具体地，涉及血管疾病的体内人源化模型的产生。 一个实施方案涉及血管疾病的体内人源化模型的用途作为测定，例如用于评估药物毒性和/或鉴定增加和减少冠心病血液流向人血管化心脏组织的药剂。 另一个实施方案涉及人原始ISL1 +祖细胞的治疗用途，例如，在一个实施方案中，本发明提供了治疗受试者心血管疾病和/或先天性心脏病的方法，所述方法包括移植入受试者从人ISL1 +祖细胞产生的血管化人心脏组织 。

公开(公告)号：US08227896B2

公开(公告)日：2012-07-24

申请号：US12636588

申请日：2009-12-11

申请人： Xin Jiang ,  Stuart Stephen Papworth Parkin ,  Mahesh Govind Samant ,  Cheng-Han Yang

发明人： Xin Jiang ,  Stuart Stephen Papworth Parkin ,  Mahesh Govind Samant ,  Cheng-Han Yang

IPC分类号： H01L29/00

CPC分类号： G11C11/5685 ,  C23C14/081 ,  C23C14/35 ,  G11C11/5671 ,  G11C13/0007 ,  G11C13/003 ,  G11C13/0069 ,  G11C17/16 ,  G11C17/165 ,  G11C2013/0073 ,  G11C2013/009 ,  G11C2213/76 ,  G11C2213/79 ,  H01L27/2436 ,  H01L27/2463 ,  H01L45/08 ,  H01L45/085 ,  H01L45/1233 ,  H01L45/146 ,  H01L45/1616 ,  H01L45/165

摘要： Nitrogen-doped MgO insulating layers exhibit voltage controlled resistance states, e.g., a high resistance and a low resistance state. Patterned nano-devices on the 100 nm scale show highly reproducible switching characteristics. The voltage levels at which such devices are switched between the two resistance levels can be systematically lowered by increasing the nitrogen concentration. Similarly, the resistance of the high resistance state can be varied by varying the nitrogen concentration, and decreases by orders of magnitude by varying the nitrogen concentrations by a few percent. On the other hand, the resistance of the low resistance state is nearly insensitive to the nitrogen doping level. The resistance of single Mg50O50-xNx layer devices can be varied over a wide range by limiting the current that can be passed during the SET process. Associated data storage devices can be constructed.

摘要翻译： 氮掺杂的MgO绝缘层表现出电压控制的电阻状态，例如高电阻和低电阻状态。 100 nm刻度的图案化纳米器件显示出高度可重现的开关特性。 通过增加氮浓度可以使这些装置在两个电阻水平之间切换的电压水平被系统地降低。 类似地，可以通过改变氮浓度来改变高电阻状态的电阻，并且通过将氮浓度改变几个百分比来降低数量级。 另一方面，低电阻状态的电阻对氮掺杂水平几乎不敏感。 单个Mg50O50-xNx层器件的电阻可以通过限制在SET过程中可以通过的电流在宽范围内变化。 可以构建相关的数据存储设备。

公开(公告)号：US20120046200A1

公开(公告)日：2012-02-23

申请号：US13288772

申请日：2011-11-03

申请人： Xianqiang Li ,  Xin Jiang

发明人： Xianqiang Li ,  Xin Jiang

IPC分类号： C40B30/00 ,  C40B30/10

CPC分类号： C40B30/04 ,  C12Q1/6897 ,  G01N33/6845

摘要： A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the sequence from the cDNA library varying within the cell library; contacting the library of cells with a plurality of agents which may affect protein degradation rates; for each agent, selecting cells in the library which express short-lived proteins based on whether the cells have different reporter signal intensities than other cells in the library, the difference being indicative of the selected cells expressing shorter lived fusion proteins than the fusion proteins expressed by the other cells in the library; and characterizing the fusion proteins expressed by the selected cells for each agent.

摘要翻译： 提供了用于筛选影响蛋白质降解速率的试剂的方法，所述方法包括：获取细胞文库，表达包含报道蛋白的融合蛋白的细胞和由源自下列样品的cDNA文库的序列编码的蛋白质： 细胞，来自cDNA文库的序列在细胞文库内变化; 使细胞库与可能影响蛋白质降解速率的多种试剂接触; 对于每个试剂，基于细胞是否具有与文库中的其他细胞不同的报道信号强度来选择表达短寿命蛋白质的文库中的细胞，所述差异表示选择的表达比所表达的融合蛋白更短的生物融合蛋白的细胞 由图书馆内的其他细胞; 并表征由所选细胞表达的每种试剂的融合蛋白。

公开(公告)号：US08095870B2

公开(公告)日：2012-01-10

申请号：US11758783

申请日：2007-06-06

申请人： Xin Jiang ,  Shirley Hong Zeng ,  Tomoji Ashitani

发明人： Xin Jiang ,  Shirley Hong Zeng ,  Tomoji Ashitani

IPC分类号： G06F17/00 ,  G06F15/00

CPC分类号： G06F17/248 ,  Y10S707/99943

摘要： In various embodiments, a method for generating documents in native application formats includes receiving a document template as a first document according to a native format. The first document is parsed to generate an Extensible Document Transformation Language (XDTL) template representing the document template. An XDTL execution document is generated based on the XDTL template. A second document is then generated according to the native format based on the XDTL execution document.

摘要翻译： 在各种实施例中，用于以本机应用格式生成文档的方法包括：根据本机格式接收作为第一文档的文档模板。 解析第一个文档以生成表示文档模板的可扩展文档转换语言（XDTL）模板。 基于XDTL模板生成XDTL执行文档。 然后根据XDTL执行文档的本地格式生成第二个文档。

公开(公告)号：US20110221505A1

公开(公告)日：2011-09-15

申请号：US12661391

申请日：2010-03-15

申请人： Xin Jiang

发明人： Xin Jiang

IPC分类号： H03H11/32

CPC分类号： H03D7/1408 ,  H03D7/1458 ,  H03D2200/0013 ,  H03D2200/0015 ,  H03H7/42

摘要： A distributed, diode mixer circuit includes a plurality of passive diode mixer cores including at least first and second passive diode mixer cores including doubly-balanced diodes in symmetrical balanced configuration forms, each mixer core having a pair of differential reference nodes driven by the reference signal and a pair of differential nodes driven by the data signal and a reactive impedance network including one or multiple reactive elements or transmission lines connected between the like nodes of each the first and second mixer cores.

摘要翻译： 分布式二极管混频器电路包括多个无源二极管混频器核心，至少包括第一和第二无源二极管混频器核心，其包括对称平衡配置形式的双平衡二极管，每个混频器核心具有由参考信号驱动的一对差分参考节点 以及由数据信号驱动的一对差分节点和包括连接在每个第一和第二混频器核心的类似节点之间的一个或多个无功元件或传输线的无功阻抗网络。

公开(公告)号：US20100330707A1

公开(公告)日：2010-12-30

申请号：US11627824

申请日：2007-01-26

申请人： Xin Jiang ,  Stuart Stephen Papworth Parkin ,  Jonathan Sun

发明人： Xin Jiang ,  Stuart Stephen Papworth Parkin ,  Jonathan Sun

IPC分类号： H01L43/12 ,  C23F4/00

CPC分类号： H01L43/12

摘要： A method for fabricating a device includes forming a first insulation layer to cover a removable mask and a device structure that has been defined by the mask. The device structure is below the mask. The mask is lifted off to expose a top portion of the device structure. A conductive island structure is formed over the first insulation layer and the exposed top portion of the device structure. The first insulation layer and the conductive island structure are covered with a second insulation layer. A contact is formed through the second insulation layer to the conductive island structure.

摘要翻译： 一种用于制造器件的方法包括形成第一绝缘层以覆盖可去除的掩模和由掩模限定的器件结构。 器件结构在掩模之下。 提起面罩以露出装置结构的顶部。 在第一绝缘层和器件结构的暴露顶部上形成导电岛结构。 第一绝缘层和导电岛结构被第二绝缘层覆盖。 通过第二绝缘层向导电岛结构形成接触。

公开(公告)号：US20100231316A1

公开(公告)日：2010-09-16

申请号：US12381465

申请日：2009-03-12

申请人： Xin Jiang

发明人： Xin Jiang

IPC分类号： H03H7/42 ,  H01P5/10

CPC分类号： H03H7/42 ,  H03D7/1408 ,  H03D2200/0013 ,  H03D2200/0023 ,  H03D2200/0074

摘要： A hybrid Marchand/back-wave balun includes a first pair of coupled sections having a first primary section and first secondary section; a second pair of coupled sections having a second primary section and second secondary section; a first reactance interconnecting the first and second primary sections and a second reactance interconnecting the first and second secondary sections; one of the reactances being open at high frequency and shorted at low frequency, the other reactance being shorted at high frequency and open at low frequency for selectively providing low frequency Marchand/high frequency back-wave function and high frequency Marchand/low frequency back-wave function; and a double balanced mixer using same.

摘要翻译： 混合Marchand /逆波平衡 - 不平衡变压器包括具有第一初级部分和第一次级部分的第一对耦合部分; 第二对耦合部分，具有第二初级部分和第二次级部分; 互连第一和第二初级部分的第一电抗和互连第一和第二次级部分的第二电抗; 其中一个电抗器在高频下开路，低频短路，另一个电抗在高频下短路，低频开路，选择性地提供低频三角和高频反波功能，高频率三通/低频背波功能， 波函数; 和使用它的双平衡混合器。

公开(公告)号：US20100197005A1

公开(公告)日：2010-08-05

申请号：US12402854

申请日：2009-03-12

申请人： Shelley Sims Belouski ,  Sirid-Aimee Kellermann ,  Michael Aidan North ,  Karin Kristina Amundson ,  Vahe Bedian ,  Dana Dan Hu-Lowe ,  Xin Jiang ,  Shannon Marie Karlicek ,  James Arthur Thomson ,  Jianying Wang ,  Grant Raymond Wickman ,  Jingchuan Zhang

发明人： Shelley Sims Belouski ,  Sirid-Aimee Kellermann ,  Michael Aidan North ,  Karin Kristina Amundson ,  Vahe Bedian ,  Dana Dan Hu-Lowe ,  Xin Jiang ,  Shannon Marie Karlicek ,  James Arthur Thomson ,  Jianying Wang ,  Grant Raymond Wickman ,  Jingchuan Zhang

IPC分类号： C12N5/10 ,  C07H21/04 ,  C12N15/74

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。