公开(公告)号：US5323133A

公开(公告)日：1994-06-21

申请号：US914248

申请日：1992-07-15

Applicant: Michael C. Heath ,  John J. Quinn

Inventor： Michael C. Heath ,  John J. Quinn

IPC: H01F7/06 ,  G01V1/18 ,  H02K5/22 ,  H02K33/18 ,  H01F7/08

CPC classification number: H02K33/18 ,  G01V1/18 ,  H02K5/225

Abstract: A device for making electrical connection to a reciprocating element, such as to a voice coil of an actuator. An electrical flow path utilizing the helical centering springs as a primary element in conducting current ensures reliable current flow to a reciprocating element and avoids high-speed flexing of brittle wires. Hard-wired connections are utilized only between stationary elements. A second double-coil actuator embodiment employs a coaxial, substantially co-extensive pair of springs as the input and return current flow paths for each actuator.

Abstract translation: 用于与往复元件（例如致动器的音圈）电连接的装置。 利用螺旋定心弹簧作为导电电流的主要元件的电流路径确保可靠的电流流向往复运动元件，并避免脆性线的高速弯曲。 硬连接仅在固定元件之间使用。 第二双线圈致动器实施例采用同轴的，基本上共同扩展的一对弹簧作为每个致动器的输入和返回电流流动路径。

公开(公告)号：US6087088A

公开(公告)日：2000-07-11

申请号：US791591

申请日：1997-01-31

Applicant: Uri Piran ,  John J. Quinn

Inventor： Uri Piran ,  John J. Quinn

IPC: G01N33/53 ,  G01N33/533 ,  G01N33/543 ,  G01N33/553 ,  C12Q1/00

CPC classification number: G01N33/5306 ,  G01N33/54313 ,  G01N33/54326

Abstract: Novel binding assay techniques have been developed which improve accuracy and sensitivity via accounting for interfering factors. They rely on use, in a simultaneous incubation, of two or more different labels, some of which are used primarily to detect analyte, and others to detect interfering substances originating in the sample. The mathematical relationships between the labels allow corrections that lead to more accurate and sensitive determination of the presence and concentration of the analyte.

Abstract translation: 已经开发了新的结合测定技术，其通过考虑干扰因素来提高准确度和灵敏度。 它们依赖于同时孵育两种或更多种不同标记物，其中一些标签主要用于检测分析物，其他标记物用于检测源自样品的干扰物质。 标签之间的数学关系允许更正，导致更准确和更灵敏地确定分析物的存在和浓度。

公开(公告)号：US08394944B2

公开(公告)日：2013-03-12

申请号：US10667191

申请日：2003-09-15

Applicant: Minxue Zheng ,  John J. Quinn ,  Brian D. Warner

Inventor： Minxue Zheng ,  John J. Quinn ,  Brian D. Warner

IPC: C07H21/04 ,  C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6858 ,  C12Q1/6827 ,  C12Q1/6832 ,  C12Q1/686 ,  C12Q2565/519 ,  C12Q2525/301 ,  C12Q2525/197 ,  C12Q2525/186 ,  C12Q2525/313

Abstract: The present invention provides primers and probes to be used in a method of enhancing hybridization of a probe to a target nucleotide sequence when the target sequence is capable of forming intramolecular secondary structures that interfere with hybridization of the probe to the target sequence. In particular, the invention includes a primer for amplifying a target nucleotide sequence, wherein at least a portion of the target nucleotide sequence can form an intramolecular secondary structure. The primer of the invention includes a primer nucleotide sequence complementary to a portion of the target nucleotide sequence that does not form a secondary structure, and a blocking sequence substantially complementary to at least a portion of the secondary structure-forming region of the amplified target nucleotide sequence, wherein the blocking sequence hybridizes to a portion of the secondary structure-forming region of the amplified target nucleotide sequence and blocks the formation of the secondary structure.

Abstract translation: 本发明提供了当靶序列能够形成干扰探针与靶序列的杂交的分子内二级结构时，用于增强探针与靶核苷酸序列的杂交的方法中的引物和探针。 特别地，本发明包括用于扩增靶核苷酸序列的引物，其中目标核苷酸序列的至少一部分可以形成分子内二级结构。 本发明的引物包括与未形成二级结构的靶核苷酸序列的一部分互补的引物核苷酸序列和与扩增的靶核苷酸的至少一部分二级结构形成区基本上互补的阻断序列 序列，其中所述阻断序列与扩增的靶核苷酸序列的二级结构形成区的一部分杂交并阻断二级结构的形成。

公开(公告)号：US20090075273A1

公开(公告)日：2009-03-19

申请号：US12092280

申请日：2006-11-09

Applicant: Ingmar Dorn ,  John J. Quinn ,  Brian D. Warner

Inventor： Ingmar Dorn ,  John J. Quinn ,  Brian D. Warner

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N21/6428 ,  G01N21/648 ,  G01N21/7703

Abstract: Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.

Abstract translation: 提供了用于使用单个荧光染料进行多重PCR和动力学PCR测定的平面波导（“PWG”）检测芯片。 PWG检测芯片安装在容纳至少一个PWG芯片的PWG检测室中。 PWG检测室可以在单室或双室配置中。 还提供了使用本发明的PWG检测室分析扩增产物的方法。

公开(公告)号：US20090023597A1

公开(公告)日：2009-01-22

申请号：US12282078

申请日：2007-04-12

Applicant: Carrie Li Wong ,  John J. Quinn ,  Brian D. Warner

Inventor： Carrie Li Wong ,  John J. Quinn ,  Brian D. Warner

IPC: C40B30/04 ,  C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6837 ,  C12Q2537/163 ,  C12Q2525/161 ,  C12Q2537/143 ,  C12Q2535/125 ,  C12Q2523/301 ,  C12Q2537/125

Abstract: The present invention provides methods, compositions and systems for the specific and selective detection of multiple single nucleotide polymorphisms (SNPs) from genomic DNA. Importantly, the inventive systems and methods eliminate the need for costly, time- and labor-intensive gene amplification that is generally carried out prior to SNP detection. Also provided are kits useful to perform the inventive methods.

Abstract translation: 本发明提供了用于从基因组DNA特异性和选择性检测多个单核苷酸多态性（SNP）的方法，组合物和系统。 重要的是，本发明的系统和方法消除了通常在SNP检测之前进行的昂贵，时间和劳动密集型基因扩增的需要。 还提供了用于实施本发明方法的试剂盒。

公开(公告)号：US5961899A

公开(公告)日：1999-10-05

申请号：US892788

申请日：1997-07-15

Applicant: Dino J. Rossetti ,  Stephen F. Hildebrand ,  John J. Quinn ,  Mark A. Norris ,  Lane R. Miller

Inventor： Dino J. Rossetti ,  Stephen F. Hildebrand ,  John J. Quinn ,  Mark A. Norris ,  Lane R. Miller

IPC: B21B1/22 ,  B21B37/00 ,  D21G1/00 ,  F16F15/02 ,  F16F15/03 ,  B29C71/00 ,  B65H18/26

CPC classification number: F16F15/02 ,  B21B37/007 ,  D21G1/008 ,  F16F15/03 ,  B21B1/222 ,  B21B2203/44

Abstract: A vibration control apparatus (20) and method for a calender (18) for controlling vibration between two or more rolls (ex. 22, 24) which controls vibration induced thickness variations in a medium (27) exiting from the nip. The apparatus (20) includes a frame (19), a first and second rolls (22, 24) mounted relative to the frame (19), and a force generator (32), such as an electromechanical active actuator, servo-hydraulic actuator, controllable semi-active damper, Active Vibration Absorber (AVA), or Adaptive Tuned Vibration Absorber (ATVA), provides cancelling forces to control vibration between the first and second roll (22, 24) thereby, controlling such vibration induced thickness variations in the medium (27). Preferably, the apparatus (20) includes at least one sensor (ex. 42, 42', 42", 42'") for providing a signal representative of a vibration condition of at least one of the first or second roll (22, 24), and preferably both, and a digital controller (50) for processing the signal representative of said vibration condition preferably according to a feed-forward-type control and providing a control signal to a force generator (32). Vertical and/or lateral vibration of the rolls (22, 24) may controlled simultaneously. Likewise, fundamental vibrational frequencies and their harmonics may be controlled individually, or in combination.

Abstract translation: 一种用于控制两个或多个辊（例如22,24）之间的振动的压光机（18）的振动控制装置（20）和方法，其控制从辊隙出来的介质（27）中的振动诱发的厚度变化。 装置（20）包括框架（19），相对于框架（19）安装的第一和第二辊（22,24）以及力发生器（32），例如机电主动致动器，伺服液压致动器 ，可控半主动阻尼器，主动减振器（AVA）或自适应调谐减振器（ATVA），提供抵消力以控制第一和第二辊（22,24）之间的振动，从而控制这种振动引起的厚度变化 中等（27）。 优选地，装置（20）包括至少一个传感器（例如42,42'，42“，42”'），用于提供表示第一或第二辊（22）中的至少一个的振动状态的信号 ，24），优选地两者，以及数字控制器（50），用于优选地根据前馈型控制来处理表示所述振动条件的信号，并向力产生器（32）提供控制信号。 可以同时控制辊（22,24）的垂直和/或横向振动。 同样地，基本的振动频率及其谐波可以单独或组合地控制。

公开(公告)号：US4469977A

公开(公告)日：1984-09-04

申请号：US435156

申请日：1982-10-19

Applicant: John J. Quinn ,  Ulrich Strom ,  Leroy L. Chang

Inventor： John J. Quinn ,  Ulrich Strom ,  Leroy L. Chang

IPC: G10K15/04 ,  H01L27/14

CPC classification number: G10K15/046 ,  Y10S505/825

Abstract: An ultrasonic wave generator comprising a semiconductor superlattice with a periodic variation in its space charge and a far infrared laser for applying a transient electric field to the superlattice transverse to the direction of its periodic variation. The ultrasonic wave produced has a wavelength of the period of the superlattice which can result in 100 gigahertz ultrasonic waves. Structure is included for guiding these waves into an acoustic system.

Abstract translation: 一种超声波发生器，包括其空间电荷周期性变化的半导体超晶格和用于向横向于其周期性变化方向的超晶格施加瞬态电场的远红外激光器。 所产生的超声波具有能够导致100千兆赫兹超声波的超晶格周期的波长。 包括用于将这些波导入声学系统的结构。