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公开(公告)号：US07034140B2
公开(公告)日：2006-04-25
申请号：US10128713
申请日：2002-04-22
申请人： Michael G. Bramucci , Patricia C. Brzostowicz , Qiong Cheng , Kristy N Kostichka , Pierre E. Rouviere , Vasantha Nagarajan , Luan Tao , Stuart M. Thomas
发明人： Michael G. Bramucci , Patricia C. Brzostowicz , Qiong Cheng , Kristy N Kostichka , Pierre E. Rouviere , Vasantha Nagarajan , Luan Tao , Stuart M. Thomas
CPC分类号： C12N15/52
摘要： Genes have been isolated from Rhodococcus erythropolis AN12 strain encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Rhodococcus strain. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.
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公开(公告)号：US07105296B2
公开(公告)日：2006-09-12
申请号：US10230026
申请日：2002-08-28
申请人： Michael G. Bramucci , Patricia C. Brzostowicz , Kristy N Kostichka , Vasantha Nagarajan , Pierre E. Rouviere , Stuart M. Thomas
发明人： Michael G. Bramucci , Patricia C. Brzostowicz , Kristy N Kostichka , Vasantha Nagarajan , Pierre E. Rouviere , Stuart M. Thomas
CPC分类号： C12N9/0073 , C12P17/08
摘要： Genes have been isolated from a variety of bacteria encoding Baeyer-Villiger monooxygenase activity. The genes and their products are useful for the conversion of ketones to the corresponding esters. A series of motifs, common to all genes, has been identified as diagnostic for genes encoding proteins of this activity.
摘要翻译： 已经从编码Baeyer-Villiger单加氧酶活性的各种细菌中分离出基因。 基因及其产物可用于将酮转化为相应的酯。 已经鉴定了所有基因共有的一系列基序作为编码该活性蛋白质的基因的诊断。
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公开(公告)号：US07416859B2
公开(公告)日：2008-08-26
申请号：US11069691
申请日：2005-03-01
CPC分类号： C12N15/74
摘要： A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterologous genes in Rhodococcus sp.
摘要翻译： 已经从包含独特复制蛋白的红球菌菌株AN12分离出质粒。 复制蛋白可用于多种克隆和表达载体，特别是用于在红球菌属中表达异源基因的穿梭载体中。
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公开(公告)号：US06949362B2
公开(公告)日：2005-09-27
申请号：US10007527
申请日：2001-12-05
IPC分类号： C12N15/09 , C07K14/195 , C12N1/21 , C12N15/31 , C12N15/74 , C12P21/06 , C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N15/74
摘要： A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterologous genes in Rhodococcus sp.
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公开(公告)号：US06461840B1
公开(公告)日：2002-10-08
申请号：US09617854
申请日：2000-07-17
IPC分类号： C12P740
CPC分类号： C12P7/46
摘要： This invention relates to a biocatalytic process to produce terephthalic acid and isophthalic acid from p-xylene and m-xylene, respectively. Terephthalic acid has been prepared by oxidizing p-xylene with bacteria belonging to the genus Burkholderia. Conversion of p-xylene into terephthalic acid is accomplished by a single bacterial strain that produces all of the requisite enzymes. In addition, this invention relates to the preparation of isophthalic acid from a mixture of m- and p-xylene.
摘要翻译： 本发明涉及分别从对二甲苯和间二甲苯生产对苯二甲酸和间苯二甲酸的生物催化方法。 对苯二甲酸已经通过用属于伯克霍尔德氏菌属的细菌氧化对二甲苯来制备。 对二甲苯转化成对苯二甲酸是通过产生所有必需酶的单一细菌菌株实现的。 此外，本发明涉及从间二甲苯和对二甲苯的混合物制备间苯二甲酸。
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公开(公告)号：US06187569B1
公开(公告)日：2001-02-13
申请号：US09342579
申请日：1999-06-29
IPC分类号： C12P100
CPC分类号： C12P7/46
摘要： This invention relates to a biocatalytic process to produce terephthalic acid and isophthalic acid from p-xylene and m-xylene, respectively. Terephthalic acid has been prepared by oxidizing p-xylene with bacteria belonging to the genus Burkholderia. Conversion of p-xylene into terephthalic acid is accomplished by a single bacterial strain that produces all of the requisite enzymes. In addition, this invention relates to the preparation of isophthalic acid from a mixture of m- and p-xylene.
摘要翻译： 本发明涉及分别从对二甲苯和间二甲苯生产对苯二甲酸和间苯二甲酸的生物催化方法。 对苯二甲酸已经通过用属于伯克霍尔德氏菌属的细菌氧化对二甲苯来制备。 对二甲苯转化成对苯二甲酸是通过产生所有必需酶的单一细菌菌株实现的。 此外，本发明涉及从间二甲苯和对二甲苯的混合物制备间苯二甲酸。
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公开(公告)号：US20100093020A1
公开(公告)日：2010-04-15
申请号：US12634753
申请日：2009-12-10
IPC分类号： C12Q1/04
摘要： Enterococcus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Enterococcus are also provided.
摘要翻译： 已经分离出对丁醇具有增强耐性的肠球菌。 该细菌可用于发酵生产丁醇。 还提供了用于分离耐丁醇肠球菌的新方法。
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公开(公告)号：US08426173B2
公开(公告)日：2013-04-23
申请号：US12110503
申请日：2008-04-28
申请人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
发明人： Michael G. Bramucci , Dennis Flint , Edward S. Miller, Jr. , Vasantha Nagarajan , Natalia Sedkova , Manjari Singh , Tina K. Van Dyk
IPC分类号： C12P7/16
CPC分类号： C12N15/74 , C12N15/70 , C12P7/16 , C12Y103/01038 , C12Y103/01044 , C12Y402/01017 , C12Y402/01055 , Y02E50/10
摘要： A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
摘要翻译： 公开了通过使用微生物生产宿主发酵生产1-丁醇的方法。 该方法在发酵过程中使用温度降低，导致生产主体对丁醇产物的更强的耐受性。
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公开(公告)号：US20120149080A1
公开(公告)日：2012-06-14
申请号：US13162165
申请日：2011-06-16
摘要： High cell density cultures of yeast were found to have higher tolerance for butanol in the medium. The high cell density yeast cultures had greater survival and higher glucose utilization than cultures with low cell densities. Production of butanol using yeast in high cell density cultures is thus beneficial for improving butanol production.
摘要翻译： 发现酵母的高细胞密度培养物对培养基中的丁醇具有较高的耐受性。 高细胞密度酵母培养物比具有低细胞密度的培养物具有更高的存活和更高的葡萄糖利用率。 因此，在高细胞密度培养物中使用酵母生产丁醇因此有利于改善丁醇生产。
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公开(公告)号：US08017364B2
公开(公告)日：2011-09-13
申请号：US11949793
申请日：2007-12-04
摘要： Pediococcus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentative production of butanol.
摘要翻译： 已经分离了对丁醇具有增强耐受性的细菌。 该细菌可用于发酵生产丁醇。
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